Indications• In the management of primary gout or secondary hyperuricaemia associated with chronic gout.
In severe cases of chronic gout, Allopurinol can be used together with a uricosuric agent unless the latter is contra-indicated.
• Uric acid nephropathy
• Recurrent uric acid stone formation
• Certain enzyme disorders or blood disorders which lead to
overproduction of urate (e.g., Lesch-Nyhan syndrome, hemolytic anaemia)
• Hyperuricaemia associated with malignancy and cytotoxic therapy which results in a high cell turnover rate
• The prevention and treatment of calcium oxalate/phosphate renal stones
in the presence of high uric acid levels of the blood and/or urine.DescriptionsAlurol
is used to decrease uric acid concentrations in plasma and/or urine
when hyperuricaemia is clinically significant. Alurol and its active
metabolite oxypurinol inhibit xanthine oxidase, the enzyme responsible
for the conversion of hypoxanthine to xanthine to uric acid. Inhibition
of this enzyme accounts for the major pharmacological effects of Alurol.
In contrast with the uricosuric agents that increase the renal
excretion of urate, Alurol inhibits the terminal steps in uric acid
90% of the Alurol from tablets is absorbed in the gastro-intestinal
tract. The Alurol is rapidly metabolized to the active metabolite
oxypurinol (alloxanthine). After administration, peak plasma levels
occur generally at 1.5 hrs for Alurol. It has a plasma half-life of
approximately 1 hour.Dosage & AdministrationAllopurinol
may be taken once daily after a meal. It is normally well tolerated
especially after food. Should the total daily dose exceed 300 mg and/or
gastro-intestinal intolerance be manifested, a divided doses regimen may
be appropriate. The dosage should be adjusted by monitoring serum urate
concentrations and urinary urate/uric acid levels at appropriate
The average daily dose is 2-10 mg/kg body weight or 100 mg to 200 mg for
mild conditions, 300 mg to 600 mg daily for moderate severe conditions
and 700 to 900 mg for severe conditions.
Allopurinol may increase the frequency of acute attacks during the first
few months of therapy; it is therefore recommended that low doses be
given initially and slowly increased, and that anti-inflammatory agents
or colchicines should be given concomitantly during this period as
prophylactic cover. In patients with renal function, doses of 100 mg
should be given and increased by 50 mg to 100 mg at weekly intervals
until serum levels of 0.6 mg per ml are achieved.
Hyperuricaemia of malignancy or cancer therapy:
Therapy should be initiated 2 to 3 days prior to cytotoxic therapy after
which maintenance doses are given according to response. Adequate
hydration is essential throughout.
Hyperuricaemia associated with malignancy:
6-10 years: 300 mg daily
Under 6 years: 150 mg daily
Impaired renal function:
100-200 mg dailySide EffectsThe
most common side effect is skin rash. Fever, chills, leucopenia,
eosinophilia, arthalgia, nausea, vomiting, abdominal pain, diarrhea,
alopecia, headache, drowsiness and peripheral neuritis are other side
should be discontinued at the first sign of a rash or other sign of
immediate allergic reactions. It is not recommended for the treatment of
mild asymptomatic hyperuricaemia.It should generally only be considered
if serum urate concentrations exceed 0.8 to 0.9 mg/ml with an aim of
reducing levels to 0.6 mg/ml.ContraindicationsAcute gout and allergy to Allopurinol.Use in Pregnancy & LactationCategory
B2. Although animal studies have not indicated any incidence of
teratogenicity, the effect of Allopurinol on the human fetus is unknown
and it should be used in pregnancy only if clearly needed.
Allopurinol is distributed into breast milk. It should be used with
caution in view of the potential for hypersensitivity reactions.Drug InteractionAllopurinol
may increase the incidence of skin rash in patients taking Ampicillin.
Aluminium hydroxide, as the antacid can reduce the absorption of
vomiting, diarrhea and dizziness have been reported who ingested 20 gm
Allopurinol. The patient should be monitored and receive normal
supportive measures and should be adequately hydrated to maintain
urinary excretion of allopurinol and its metabolites.Commercial PackagingAlurol 100 mg tablet: Each box contains 10 blister strips of 10 tablets..
Aristovit® M is sugar-coated multivitamin mineral tablet. Aristovit® -M
is indicated in deficiency states in acute and chronic disease.
Conditions regarding specific support: pregnancy, lactation, menopause,
during treatment with antibiotics. The comprehensive formulae of
Aristovit® M assures liberal amounts of important vitamins,
minerals and trace elements needed by the body during periods of
increased energy requirements such as in disease and convalescence.Provides 11 vitamins, 5 minerals & Iron in a single dose formulationTime-tested multivitamin & mineral brandSophisticated technology is utilized to produce the highest quality productProvides vitamin & mineral supplementation at an affordable costMeets the US recommended daily allowances (RDA) of vitamins & minerals..