Roche Bangladesh Limited

  Latest
Contour Plus One meter-5%

Contour Plus One meter

 Tk.2,000.00/=  Tk.1,899.00/=
Trulicity 0.75/0.5ml

Trulicity 0.75/0.5ml

Tk.3,395.00/=
MaxD 40000 IU Capsule
Smile Baby Diaper 5's M
Smile Baby Diaper 5's S
Raja Super Condom
Amore Black Condom

Amore Black Condom

Tk.100.00/=
Amore gold condom

Amore gold condom

Tk.100.00/=
Hero Condom 1 packet
Terbin 15 gm Cream

Terbin 15 gm Cream

Tk.80.00/=
Valmor 100 Tablet

Valmor 100 Tablet

Tk.85.00/=
Tolfem 200 mg Tablet
Actemra IV Infusion 162mg 0.9 ml

Actemra IV Infusion 162mg 0.9 ml

IndicationsRheumatoid Arthritis (RA): Tocilizumab is indicated for the treatment of adult patients with moderately to severely active rheumatoid arthritis who have had an inadequate response to one or more Disease-Modifying Anti-Rheumatic Drugs (DMARDs).Giant Cell Arteritis (GCA): Tocilizumab is indicated for the treatment of giant cell arteritis (GCA) in adult patients.Polyarticular Juvenile Idiopathic Arthritis (PJIA): Tocilizumab is indicated for the treatment of active polyarticular juvenile idiopathic arthritis in patients 2 years of age and older.Systemic Juvenile Idiopathic Arthritis (SJIA): Tocilizumab is indicated for the treatment of active systemic juvenile idiopathic arthritis in patients 2 years of age and older.Cytokine Release Syndrome (CRS): Tocilizumab is indicated for the treatment of chimeric antigen receptor (CAR) T cell-induced severe or life-threatening cytokine release syndrome in adults and pediatric patients 2 years of age and older.* চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুনTherapeutic ClassDrugs used for Rheumatoid ArthritisPharmacologyTocilizumab is a recombinant humanized anti-human interleukin 6 (IL 6) receptor monoclonal antibody of the immunoglobulin (Ig) IgG1 subclass. Tocilizumab binds specifically to both soluble and membrane-bound IL 6 receptors (sIL 6R and mIL 6R), and has been shown to inhibit sIL 6R and mIL 6R-mediated signaling. Interleukin-6 is a multi-functional cytokine, produced by a variety of cell types involved in local paracrine function as well as regulation of systemic physiological and pathological processes eg, induction of immunoglobulin secretion, T-cell activation, induction of hepatic acute phase proteins and stimulation of haematopoiesis. Interleukin-6 has been implicated in the pathogenesis of diseases including inflammatory diseases, osteoporosis and neoplasia. The possibility exists for tocilizumab to affect host defences against infections and malignancies. The role of IL-6 receptor inhibition in the development of malignancies is not known.Dosage & AdministrationGeneral (IV or SC Injection): Substitution by any other biological medicinal product requires the consent of the prescribing physician.For adult patients with RA, tocilizumab may be administered as an IV infusion or a SC injection. For patients with pJIA and sJIA, tocilizumab is administered as an IV infusion.Tocilizumab IV formulation should be diluted by a healthcare professional with sterile 0.9% w/v sodium chloride solution using aseptic technique (see Caution for Usage).Tocilizumab is recommended for IV infusion over 1 hr.Tocilizumab SC formulation is administered with a single-use PFS+NSD or pre-filled pen. The 1st injection should be performed under the supervision of a qualified healthcare professional. The recommended injection sites (abdomen, thigh and upper arm) should be rotated and injections should never be given into moles, scars or areas where the skin is tender, bruised, red, hard or not intact.SC Injection: Adults: Rheumatoid Arthritis (RA): Recommended Dose: 162 mg given once every week as a SC injection. Tocilizumab can be used alone or in combination with MTX and/or other DMARDs.Patients transitioning from tocilizumab IV therapy to SC administration should administer the 1st SC dose at the time of the next scheduled IV dose under the supervision of a qualified healthcare professional.Tocilizumab SC formulation is not intended for IV administration.  Assess suitability of patient for SC home use and instruct patients to inform a healthcare professional if they experience symptoms of allergic reaction before administering the next dose. Patients should seek immediate medical attention if developing symptoms of serious allergic reactions* চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুনInteractionInteractions with Other Medicinal Products and Other Forms of Interaction: Population pharmacokinetic analyses did not detect any effect of MTX, nonsteroidal anti-inflammatory drugs or corticosteroids on tocilizumab clearance.Concomitant administration of a single dose of 10 mg/kg tocilizumab with 10-25 mg MTX once weekly had no clinically significant effect on MTX exposure.Tocilizumab has not been studied in combination with other biological DMARDs.The expression of hepatic CYP450 enzymes is suppressed by cytokines, eg, IL-6, that stimulate chronic inflammation. Thus, CYP450 expression may be reversed when potent cytokine inhibitory therapy, eg, tocilizumab is introduced.In vitro studies with cultured human hepatocytes demonstrated that IL-6 caused a reduction in CYP1A2, CYP2C9, CYP2C19 and CYP3A4 enzyme expression. Tocilizumab normalizes expression of these enzymes. The effect of tocilizumab on CYP enzymes (except CYP2C19 and CYP2D6) is clinically relevant for CYP450 substrates with a narrow therapeutic index and/or where the dose is individually adjusted.In a study in RA patients, levels of simvastatin (CYP3A4) were decreased by 57% one week following a single dose of tociliz..

Tk.14,950.00/=

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Avastin 400 mg/16 ml IV Infusion

Avastin 400 mg/16 ml IV Infusion

Avastin 400 mg/16 ml IV Infusion..

Tk.78,000.00/=

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Mircera 75

Mircera 75

75 µg/0.3 mlRoche Bangladesh LimitedIndicationsThis is indicated for the treatment of anemia associated with chronic kidney disease (CKD) including patients on dialysis and patients not on dialysis.PharmacologyMethoxy polyethylene glycol-epoetin beta is a chemically synthesized continuous erythropoietin receptor activator. Methoxy polyethylene glycol-epoetin beta differs from erythropoietin through integration of an amide bond between either the N-terminal amino group or the ε amino group of lysine, predominantly Lys52 and Lys45 and methoxy polyethylene glycol butanoic acid. This results in a molecular weight of approximately 60,000 daltons for methoxy polyethylene glycol-epoetin beta with the PEG-moiety having an approximate molecular weight of 30,000 daltons.In contrast with erythropoietin, methoxy polyethylene glycol-epoetin beta shows a different activity at the receptor level characterized by a slower association to and faster dissociation from the receptor, a reduced specific activity in vitro with an increased activity in vivo, as well as an increased half-life. These differential pharmacological properties are relevant in order to achieve a once monthly dosing regimen with methoxy polyethylene glycol-epoetin beta in patients.Methoxy polyethylene glycol-epoetin beta stimulates erythropoiesis by interaction with the erythropoietin receptor on progenitor cells in the bone marrow. As primary growth factor for erythroid development, the natural hormone erythropoietin is produced in the kidney and released into the bloodstream in response to hypoxia. In responding to hypoxia, the natural hormone erythropoietin interacts with erythroid progenitor cells to increase red cell production...

Tk.7,100.00/=

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