Tk.415.00/=
Indication: Type 1 and Type 2 Diabetes Mellitus.
Dosage & Administration
The
dosage form, the dosage and the administration time of the insulin are
different due to the individual differences of each patient. In addition, the
dosage is also affected by food, working style and exercising intensity.
Therefore, patients should use the insulin under doctor\'s instruction. The
average range of total daily insulin requirement for maintenance therapy in
type 1 diabetic patients lies between 0.5 and 1.0 IU/kg. In pre-pubertal
children it usually varies from 0.7 to 1.0 IU/kg, whereas in insulin resistant
cases, e.g. during puberty or due to obesity, the daily insulin requirement may
be substantially higher. Initial dosages for type 2 diabetic patients are often
lower, e.g. 0.3 to 0.6 IU/kg/day.
PHARMACOLOGY
Ansulin®
is human insulin made by DNA recombinant technology so it has the same
structure and function as
natural insulin. The product can regulate the glucose metabolism and stimulate
the ingestion and utilization
of glucose by liver, muscles, and fat tissue. It can accelerate the transformation from glucose to glycogen stored
in muscles and liver and inhibit the gluconeogenesis,
thus, to lower the blood glucose. Normally, Ansulin® R takes effect within 30 minutes after injection, reaches its peak within
1-3 hours and lasts about 4-8 hours. On the other hand, Ansulin® N comes into effect slowly after
injection, reaches its peak within 6-9 hours & lasts about 24 hours. Ansulin® 30/70 & Ansulin®
50/50 take effect within 30 minutes after injection, reach their peaks within 2-8 hours and last
about 24 hours.
USAGE
1.
Ansulin® should be injected subcutaneously 15 minutes to one hour before meal.
The exact time for
administration is suggested by doctors with regard to each individual's case.
2.
Prepare before use Firstly,
clean your hands. Shake or rotate the vial gently to mix the solution uniformly
and check if the insulin has
the normal appearance.
If
using a new Ansulin® bottle then flip off the plastic protective cap and wipe
the rubber stopper with an
alcohol swab. Draw air into
your syringe equal to the amount of insulin needed. Puncture the needle into
the vial and inject the air. Turn the bottle and syringe upside down.
Withdraw correct dose of insulin into the syringe. Before pulling out the needle, check if there
are any bubbles remain in the syringe. If
so, put the syringe upright and tap the syringe to discharge the air bubbles.
3.
Injection Site Choose the area
where skin is less tight, such as the upper arm, thigh, buttock and abdomen,
etc. To avoid tissue damage,
choose a site for each injection that is at least 1 cm from the previous
injection site.
4.
Injection Method Cleanse the
skin with alcohol where the injection is to be made. Put the needle in such a
position as to form 45° angle
with the skin. Puncture the needle into skin and inject insulin. Then pull the needle out and apply gentle pressure over the
injected site for several seconds. Do not rub the injection site.
DOSAGE
The
dosage form, the dosage and the administration time of the insulin are
different due to the individual
differences of each patient. In addition, the dosage is also affected by food,
working style and exercising
intensity. Therefore, patients should use the insulin under doctor's
instruction. The average range
of total daily insulin requirement for maintenance therapy in type 1 diabetic patients lies between 0.5 and 1.0 IU/kg. In
pre-pubertal children it usually varies from 0.7 to 1.0 IU/kg, whereas in insulin resistant cases, e.g.
during puberty or due to obesity, the daily insulin requirement may be substantially higher. Initial
dosages for type 2 diabetic patients are often lower, e.g. 0.3 to 0.6 IU/kg/day.
ADVERSE
EFFECT
Hypoglycemia
is the most common adverse effect during insulin treatment and symptoms of hypoglycemia may occur suddenly. Few cases of
the allergic reaction such as red and swollen or itching are reported. It usually disappears in a
few days. In some instances, the allergy may be caused by other reasons rather than insulin,
such as disinfectant and poor injection technique.
CONTRAINDICATION
Hypoglycemia
or the patients who have allergic reaction to insulin or any of the excipients.
PRECAUTION
Inadequate
dosing or discontinuation especially in type 1 diabetes, may lead to
hyperglycemia. Hypoglycemia
may occur if the insulin dose is too high in relation to the insulin
requirement. Omission of a
meal or unplanned, strenuous physical exercise may lead to hypoglycemia.
PREGNANCY
AND LACTATION
There
are no restrictions on treatment of diabetes with insulin during pregnancy, as
insulin does not pass the
placental barrier. Insulin treatment of the nursing mother presents no risk to
the baby.
DRUG
INTERACTION
When
using oral contraceptive drug, adrenal cortical hormone, thyroid hormone, etc.,
the drugs that can result in
the rise of blood glucose; you might need to increase the amount of Insulin.
When using drugs with
hypoglycemic activities, salicylate, sulfanilamide and other anti-depressants,
which will result in the decrease of blood
glucose, the dosage of insulin should be reduced.
OVER
DOSAGE
Excessive
use of insulin may lead to hypoglycemia during the treatment. Slight to
moderate hypoglycemia may
suddenly occur. It is important to get immediate treatment when hypoglycemia occurs. If you have frequent hypoglycemia, you
should consult your doctor to discuss possible changes in therapy, diet plans, and/or exercise
programs to help you avoid hypoglycemia.
STORAGE
Store
at 2°C - 8°C in a refrigerator. Do not freeze. In case of insulin for recent
use need not be refrigerated,
try to keep it in a cool place and keep away from heat and light. The insulin
in use can be kept under the
room temperature for a month.
Tags: Ansulin 30/70 100IU/ml (10ml) Inj, Insulin Human (rDNA), Insulin