doxiva-200-mg-tab, 1 strip
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- Stock: In Stock
- Brand: NIPRO JMI Pharma Ltd.
- Product ID: Doxophylline 200 mg
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Doxiva 200 mg Tab, 1 strip
Description:
Doxiva (Doxophylline) is a novel bronchodilator. It structurally differs from Theophylline due to the presence of a dioxolane group in position 7. Doxophylline selectively inhibits phosphodiesterase-4 thereby relaxes bronchial smooth muscle. However, differently from Theophylline, Doxophylline appears to have decreased affinities toward adenosine A1 and A2 receptors, which may account for the better safety profile of the drug. Doxophylline is reported to inhibit platelet activating factor (PAF) and generation of leukotriene production.
Indication
Doxiva (Doxophylline) is used to treat asthma, COPD and bronchospasm.
Dosage & Administration
Adults : 1 tablet daily in the evening. On the basis of clinical response the dose may be increased to 1 tablet twice daily.
Children (above 6 years of age) : 6 mg/kg twice daily.
Children (above 6 years of age) : 6 mg/kg twice daily.
Contraindication
Doxophylline is contraindicated in acute myocardial infarction. It is also contraindicated in patients with hypotension, in lactating women & patients who have shown hypersensitivity to its components
Precaution
The half-life of xanthine derivatives is influenced by a number of known variables. It may be prolonged in patients with liver disease, in patients with congestive heart failure and in those patients taking certain other drugs like erythromycin, troleandomycin, lincomycin, allopurinol, cimetidine, propanolol and anti-flu vaccine. In these cases, a lower dose of Doxophylline may be needed. Phenytoin, other anticonvulsants and smoking may cause an increase in clearance with a shorter mean half-life. In these cases higher doses of Doxophylline may be needed.
Side Effects
Doxophylline rarely causes serious side effects, however possible side effect are similar for taking excess amount of caffeine. These include: nausea, vomiting, headaches, upset stomach and heartburn.
Drug Interaction
Doxiva (Doxophylline) is used to treat asthma, COPD and bronchospasm.
Pregnancy & Lactation
Animal reproduction studies indicate that, Doxophylline does not cause fetal harm when administered to pregnant animals or can not affect reproduction capacity. However, since there is limited experience in human during pregnancy, xanthines should be given to pregnant women only if clearly needed. Doxophylline is contraindicated in nursing mothers.
Storage Condition
Keep in a dry place away from light and heat. Keep out of the reach of children.
