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Esotor 20 mg Tablet (Enteric Coated), 1 strip
Description:
Esotor (Esomeprazole) is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell. Esomeprazole (S-isomer of omeprazole) is the first single optical isomer of proton pump inhibitor, provides better acid control than racemic proton pump inhibitors.
Indication
Treatment of Gastroesophageal Reflux Disease (GERD). Healing of erosive esophagitis. Maintenance of healing of erosive esophagitis. Symptomatic Gastroesophageal Reflux Disease (GERD). Reduction of NSAID-associated gastric ulcer and H. pylori eradication (Triple therapy).
Contraindication
Esomeprazole is contraindicated in those patients who have known hypersensitivity to any other components of the formulation.
Precaution
Exclude the possibility of malignancy when gastric ulcer is suspected and before treatment for dyspepsia. When using in combination with antibiotic, refer to the prescribing information of the respective antibiotics.
Side Effects
Side effects reported with Esomeprazole include headache, diarrhea and abdominal pain.
Drug Interaction
Esomeprazole appears to be a selective inhibitor of the cytochrome p450 mono-oxygenase system, there may be an effect on hepatic clearance, but there have been no reports to date of clinically relevant interactions. There is some uncertainty over the effect of Esomeprazole on the oral combined contraceptive pill. Physiological changes similar to those found with omeprazole are likely to take place because of the reduction in gastric acid which is likely to influence the bacterial colonization of the stomach and duodenum and also vitamin B12 absorption.
Pregnancy & Lactation
US FDA pregnancy category B. Studies have been performed in animals and have revealed no evidence of impaired fertility or harm to the fetus due to Esomeprazole. There are however, no adequate and well-controlled studies in pregnant women. Esomeprazole is likely to be excreted in human milk, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Storage Condition
Keep in dry place and away from light and heat. Keep out of the reach of children.
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