A-Cal 500 mg TabDESCRIPTIONCalcium is an essential body electrolyte. It is involved in the maintenance of normal muscle and nerve function, cardiac function and is essential to blood coagulation.Calcium Carbonate has three main actions: it supplements dietary calcium, neutralizes gastric acid in peptic ulcer disease and sequesters phosphorous in the intestine to reduce total body phosphate accumulation in chronic renal failure. Calcium requirement varies with age and is relatively greater in childhood, pregnancy and lactation dueto an increased demand, in old age due to impaired absorption, and as phosphate binder in patients with renal failure. Absorption depends on previous intake of calcium, other nutrients, pregnancy, lactation, overall calcium balance and availability of vitamin D.COMPOSITIONA-CAL 250 chewable : Each chewable tablet contains Calcium Carbonate BP 0.625 g equivalent to 250 mg elemental Calcium. A-CAL 250 : Each film-coated tablet contains Calcium Carbonate BP 0.625 g equivalent to 250 mg elemental Calcium. A-CAL 500 : Each film-coated tablet contains Calcium Carbonate BP 1.25 g equivalent to 500 mg elemental Calcium.INDICATIONSIn calcium deficiency states : Treatment of calcium deficiency states including osteomalacia, rickets and mal-absorption syndromes affecting the upper gastrointestinal tract.As therapeutic supplementation : During times when intake may be inadequate, particularly those associated with the increased demand of childhood, old age, pregnancy and lactation. As a phosphate binder : As effective phosphate binder given by mouth to reduce phosphate absorption from the gut in patient with hyperphosphataemia, chronic renal failure in order to prevent the development of renal osteo-dystrophy. Osteoporosis : An adjunct to conventional therapy in the arrest or slowing down of bone demineralisation in osteoporosis or when other effective treatment is contraindicated. As an antacid : Usually in association with other antacids, especially magnesium containing antacids.DOSAGE AND ADMINISTRATIONA-Cal 250 :Adults : 2 tablets daily.Children : 1-2 tablets daily.A-Cal 500 : 1 tablet daily.OR AS DIRECTED BY THE PHYSICIAN.SIDE EFFECTSMild gastrointestinal disturbances may occur rarely (e.g. nausea, abdominal pain, constipation, flatulence and eructation etc.)CONTRAINDICATIONSCalcium Carbonate is contraindicated in hypercalcemia and hyperparathyroidism, hypercalcemia and nephrolithiasis, Zollinger Ellison Syndrome etc.PRECAUTIONSShould be used with caution in patients with impaired renal function, a history of stone formation should also be recommended to increase their fluid intake. High doses of vitamin D should be avoided during calcium therapy unless specially indicated. In case of hypercalciuria the dosage should be reduced or treatment stopped.USE IN PREGNANCY AND LACTATIONCalcium supplements have been in wide use for many years without apparent ill consequence.DRUG INTERACTIONSCalcium Carbonate and other antacids may interfere with the absorption of concomitantly administered tetracycline preparations or ciprofloxacin. This can be minimized by giving Calcium Carbonate and the other medication 2 to 3 hours apart.SUPPLYA-CAL 250 chewable : Each box contains 3 X 10 tablets in blisterstrips.A-CAL 250 : Each box contains 10 X 10 tablets in blister strips.A-CAL 500 : Each box contains 10 X 10 tablets in blister strips...
A-Cal 500/400 IU Tablet DX 30's packDESCRIPTIONA-Cal DX tablet is a special preparation of Calcium and Vitamin D3. Calcium is an essential nutrient that helps to build and maintain healthy teeth and bones. It makes body’s framework stronger by building bone.COMPOSITIONEach film-coated tablet contains Calcium Carbonate BP equivalent to elemental Calcium 500 mg and Vitamin D3 (Cholecalciferol) BP 400 IU.INDICATIONFor the prevention and/or treatment of osteoporosis,fractures,osteomalacia,rickets,tetany,pse udo-parathyroidism, for healthy bone formation and maintenance and other calcium and/or vitamin D deficiencies and to meet increased needs of calcium and/or vitamin D. Dosage and Administration: The recommended starting dose of A-Cal DX (Calcium 500 mg & Vitamin D 400 IU) 1 tablet twice daily, preferably with or just after meals.SIDE EFFECTSThe use of calcium supplements may cause constipation, and headache; mild hypercalcemia associated with anorexia, nausea and vomiting; more severe hypercalcemia associated with confusion, delirium, stupor and coma. The use of vitamin D may cause weakness, headache, somnolence, nausea, vomiting, dry mouth, constipation, muscle pain, bone pain, metallic taste, polyuria, polydipsia, anorexia, weight loss, nocturia and mild acidosis. CONTRAINDICATION A-Cal DX is contraindicated in patients Having hyperalcaemia, severe hypercalciurea, ventricular fibrillation, hypervitaminosis, severe renal failure and kidney stones and hypersensitivity to any of the ingredients of the product.PRECAUTIONPatients with mild to moderate renal failure or mild hypercalciuria should be supervised carefully. Periodic checks of plasma calcium levels and urinary calcium excretion should be made in patient with a history of renal stones or in patients with mild to moderate renal failure or mild hypercalciuria. USE IN PREGNANCY AND LACTATION A-Cal DX should be used under the direction of a physician during pregnancy and lactation. During pregnancy, doses of vitamin D greater than the recommended dietary allowance should be used only when clearly needed.DRUG INTERACTIONCo-administration of calcium with some drugs such as tetracycline antibiotics (e.g., doxycycline, minocycline), estramustine, levothyroxine, and quinolone antibiotics (e.g. ciprofloxacin, levofloxacin) can decrease the absorption of both calcium and the co-administered drug. Certain medications can decrease the absorption of vitamin D e.g., bile acid sequestrates such as cholestyramine/colestipol, ketoconazole, mineral oil, orlistat. Certain drugs can accelerate the absorption of vitamin D e.g. phenytonin, phenobarbital.SUPPLYEach plastic container contains 30 tablets...
A-Cal D 30s TabDESCRIPTIONA-CAL D tablet is a special preparation of Calcium and Vitamin D3. Calcium is an essential nutrient that helps to build and maintain healthy teeth and bones. It makes body's framework stronger by building bone. Most notably, Calcium helps to reduce the risk of osteoporosis, a disease that's characterized by a decrease in bone mass and an increase in bone fractures. Calcium also plays a role in muscle contraction, blood clotting and nerve function.Vitamin D3 is essential for healthy bones as it aids in calcium absorption from the GI tract. In addition to this it stimulates bone formation. Controlled clinical studies showed that Calcium and Vitamin D3 has synergistic effects on bone growth as well as in osteoporosis and fracture prevention.COMPOSITIONEach film-coated tablet contains elemental Calcium 500 mg and Vitamin D3 200 IU.INDICATIONSPrevention and treatment of osteoporosis and fractures (both vertebral and non-vertebral); treatment of osteomalacia, rickets, tetany, hypoparathyroidism and secondary hyperparathyroidism; in kidney disease, pancreatitis, hyperoxaluria; as phosphate binder to reduce phosphate absorption in patients with hyperphosphatemia; during therapy with antiseizure medications, bisphosphonates in paget's disease; for healthy bone formation and maintenance; in disorders of osteogenesis and tooth formation (in addition to specific treatment); inpregnancy and lactation due to increased demand; in raised calcium requirement for children and adolescents at times of rapid growth; to prevent and cure calcium deficiency and/or vitamin D deficiency especially in the household people who do not get direct sunlight. DOSAGE AND ADMINISTRATION Adults, Elderly and children: 1 tablet twice daily. OR AS DIRECTED BY THE PHYSICIAN.SIDE EFFECTSThe use of calcium supplements may cause constipation, and headache; mild hypercalcemia associated with anorexia, nausea and vomiting; more severe hypercalcemia associated with confusion, delirium, stupor and coma. The use of vitamin D may cause weakness, headache, somnolence, nausea, vomiting, dry mouth, constipation, muscle pain, bone pain, metallic taste, polyuria, polydipsia, anorexia, weight loss, nocturia and mild acidosis.PRECAUTIONSPatients with mild to moderate renal failure or mild hypercalciuria should be supervised carefully. Periodic checks of plasma calcium levels and urinary calcium excretion should be made in patients with a history of renal stones or in patients with mild to moderate renal failure or mild hypercalciuria. With long term treatment it is advisable to monitor serum and urinary calcium levels and kidney function and reduce or stop treatment temporarily if serum calcium level exceeds 12 mg/dl. Calcium salt should be used cautiously in patients with sarcoidosis, history of nephrolithiasis, cardiac disease and in patients receiving cardiac glycosides.CONTRAINDICATIONSIt is contraindicated in patients having hypercalcaemia and severe hypercalciurea, ventricular fibrillation, hypervitaminosis, severe renal failure, kidney stones and hypersensitivity to any of the ingredients of the product.DRUG INTERACTIONA-CAL D should not be used with the following medications because ofpossible interactions - Iron; digoxin; verapamil; calcium, aluminium or magnesium containing antacids; other calcium or vitamin D supplements (e.g., calcitriol). Bran decreases the gastrointestinal absorption of calcium and may therefore decrease the efficacy of calcium supplements. Concurrent administration of thiazide diuretics may increase the risk of hypercalcemia. Co-administration of calcium with some drugs such as tetracycline antibiotics (e.g., doxycycline, minocycline), estramustine, levothyroxine, and quinolone antibiotics (e.g., ciprofloxacin, levofloxacin) can decrease the absorption of both calcium and the co-administered drug. Certain medications can decrease the absorption of vitamin D e.g., bile acid sequestrates such as cholestyramine/ colestipol, ketoconazole, mineral oil, orlistat. Certain drugs can accelerate the absorption of vitamin D e.g., phenytoin, phenobarbital.OVER DOSAGEIf calcium supplements are taken at overdose for long time then hypercalcimia and hypercalciuria may rise. Symptoms of overdosage of vitamin D supplements include weakness, lassitude, impaired memory, dementia, depression, paranoia, hallucinations, delirium and coma. In case of overdose supplement should be discontinued. Treatment includes saline administration, furosemide diuresis and sometimes corticosteroids.USE IN PREGNANCY AND LACTATIONA-CAL D should be used under the direction of a physician during pregnancy and lactation. Vitamin D and its metabolites pass into the breast milk in limited amounts.SUPPLY30 Tablet Pack : Each airtight plastic container contains 30 tablets.15 Tablet Pack : Each airtight plastic container contains 15 tablets...
Acme's Hartmann Solution IV Infusion 1000 ml bagDESCRIPTIONACME’s Hartmann Solution is a sterile solution of Sodium Chloride, Potassium Chloride, Calcium Chloride and Sodium Lactate.COMPOSITIONEach 100ml of ACME’s Hartmann Solution contains Sodium Chloride BP 0.6 g, Potassium Chloride BP 0.04 g, Calcium Chloride BP 0.027 g and Sodium Lactate 50% solution USP equivalent to 0.32 g of Sodium Lactate. The solution contains per litre Sodium 131 mmol, Potassium 5 mmol, Calcium 2 mmol, Bicarbonate (as lactate) 29 mmol, and Chloride 111 mmol.INDICATIONSACME’s Hartmann Solution is used to treat hypovolemia caused by surgery, hemorrhage and trauma. Excessive sweating, severe diarrhoea or vomiting, excess loss of fluid by nephrotic kidneys, inadequate intake of fluid and electrolytes etc. that may lead to typical hypovolemic shock may be corrected with ACME’s Hartmann Solution. Severe plasma loss caused by intestinal obstruction, burns or other denuding conditions of the skin may be treated with ACME’s Hartmann Solution. ACME’s Hartmann Solution is mainly used as a fluid and electrolyte replenisher.DOSAGE AND ADMINISTRATIONThe volume and rate of infusion will depend upon the requirements of the patients and the judgement of the physician. The recommended flow rate is up to 100-drops/minute/70 kg body weight. ..
1. What Aristocal® D is and what it is used for? Aristocal® D is a combined preparation of Calcium and Vitamin D (Cholecalciferol) specially designed to promote bone health.
2. Before you take Aristocal® D
Do not take this medicine and tell your doctor if: Aristocal® D is contraindicated in patients who have known hypersensitivity to any of the components of this preparation.Taking other medicines Concurrent
administration of Thiazide diuretics may increase the risk of
hypercalcemia. Bran decreases the gastro-intestinal absorption of
calcium, and may therefore decrease the efficacy of calcium supplements.
Calcium salts reduce the absorption of a number of other drugs such as
Biphosphonates, Fluoride, some Fluoroquinolones and Tetracyclines.
Pregnancy and breast-feedingAristocal® D should be used considering the risk benefit ratio.3. How to take Aristocal® D Always use Aristocal® D exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure.
How much to take One tablet twice daily with food or as directed by the physician.
If you take more Aristocal® D than you should: If you have too much of this medicine, talk to your doctor straight away.
If you forget to take Aristocal® D
If you forget to take a dose, take it as soon as you remember it.
However, if it is nearly time for the next dose, skip the missed dose.
Do not take a double dose to make up for a forgotten dose
If you stop taking Aristocal® D Do not stop taking this medicine without talking to your doctor. You should not stop taking Aristocal® D just because you feel better. This is because the problem may come back or get worse again.
If you have any further questions on the use of this product, ask your doctor or pharmacist.
4. Possible side effects Aristocal® D is well tolerated. Mild gastrointestinal disturbances may occur.Tell
your doctor if any of the side effects gets serious or lasts longer
than a few days, or if you notice any side effects not listed in this
5. How to store Aristocal® D Store in a cool and dry place, away from light. Keep out of reach of children
Indication: Fast relief from hyperacidity and related symptoms like acid indigestion, heartburn, sour stomach and upset stomach.Dosage & Administration:2-3 tablets when symptoms occurs; may be repeated hourly if needed or as directed by the physicians...
Calvimax-D Tablet 30's pack: ৳ 150DescriptionCalcium is an essential element and plays vital roles in the body. It helps body's framework stronger by building bone. Clinical evidence suggests that calcium is useful for prevention and treatment of osteoporosis and associated fractures. Vitamin-D is also essential for healthy bones as it aids in calcium absorption from the GI tract. In addition to this it stimulates bone formation. Controlled clinical studies shows that calcium and vitamin-D has synergistic effects on bone growth as well as in osteoporosis and fracture prevention.Indications• Treatment of osteoporosis, rickets, osteomalacia, tetany and hypoparathyroidism• In pregnancy & lactation due to increase demand• In kidney disease and pancreatitis• During therapy with antiseizure medications• The prevention and treatment of calcium deficiency/vitamin D deficiency especially in the housebound and institutionalized elderly subjects.Dosage & AdministrationAdults and Elderly and children above 12 years of age: 2 tablets per day, preferably one tablet each morning and evening.Children: Not recommended for children under 12 years.Side EffectsThe use of calcium supplements has, rarely, given rise to mild gastro-intestinal disturbances, such as constipation, flatulence, nausea, gastric pain, diarrhoea. Following administration of vitamin D supplements occasional skin rash has been reported. Hypercalciuria, and in rare cases hypercalcaemia have been seen with long term treatment at high dosages.PrecautionsPatients with mild to moderate renal failure or mild hypercalciuria should be supervised carefully. Periodic checks of plasma calcium levels and urinary calcium excretion should be made in patients with mild to moderate renal failure or mild hypercalciuria. Urinary calcium excretion should also be measured. In patients with a history of renal stones urinary calcium excretion should be measured to exclude hypercalciuria. With long-term treatment it is advisable to monitor serum and urinary calcium levels and kidney function, and reduce or stop treatment temporarily if urinary calcium exceeds 7.5mmol/24 hours. Allowances should be made for calcium and vitamin D supplements from other sources.Use in Pregnancy & LactationDuring pregnancy and lactation treatment should always be under the direction of a physician. During pregnancy and lactation, requirements for calcium and vitamin D are increased but in deciding on the required supplementation allowances should be made for availability of these agents from other sources. If calcium iron supplements are both required to be administered to the patient, they should be taken at different times. Overdoses of vitamin D have shown teratogenic effects in pregnant animals. In humans, long term hypercalcaemia can lead to physical and mental retardation, aortic stenosis and retinopathy in a new born child. Vitamin D and its metabolites pass into the breast milk.Over DoseThe most serious consequence of acute or chronic overdose is hypercalcaemia due to vitamin D toxicity. Symptoms include nausea, vomiting, polyuria, and constipation. Chronic overdoses can lead to vascular and organ calcification as a result of hypercalcaemia. Treatment should consist of stopping all intake of calcium and vitamin D and rehydration...
DescriptionCalcium Dobesilate is a vasoactive drug that presumes effects on endothelial integrity, capillary permeability and blood viscosity. It decreases capillary hyperpermeability, decreases platelet aggregation (clotting - adhesion of platelets) and reduces the serum viscosity, which improves blood circulation and blood supply to tissues and organs.IndicationsDobesil is indicated for the treatment of hemorrhoidal syndrome, microcirculation disorders of arteovenous origin, clinical signs of chronic venous insufficiency in the lower limbs (pain, cramps, paresthesia, edema, stasis, dermotosis) and in the particular microangiopathy like diabetic retinopathy. It is also indicated in superficial thrombophlebitis as adjuvant therapy.Dosage & AdministrationDobesil capsule once or twice daily should be taken with the main meal. Treatment duration, which generally between a few weeks to several months, depends on the disease and its evolution. Dosage should be adapted individually according to the severity of the disease.Side EffectsRarely gastrointestinal disorders including nausea and diarrhea, skin reactions, fever, articular pain and in very rare cases agranulocytosis have been reported. These reactions are generally spontaneously reversible after treatment withdrawal.PrecautionsDosage should be reduced in case of severe renal insufficiency requiring dialysis. In patient with agranulocytosis, this medication can decrease the number of white blood cells which affect the body’s ability to fight against various infections. If patients experience flu-like symptoms such as cough, sore throat, fever and others, they are advised to seek medical care as soon as possible.Use in Pregnancy & LactationThe safety of Calcium Dobesilate during pregnancy and lactation has not been established. As it is not known whether calcium dobesilate crosses the placental barrier in humans, the drug should be administered during pregnancy only if the benefit to the mother outweighs the potential risk to the fetus. Avoid breastfeeding while using this medicine.Over DoseThe clinical signs of a possible overdose are not known. If overdose occurs, seek medical advice immediately.StorageStore in a cool and dry place, away from light. Keep out of the reach of children...
Fizycal-D Effervescent Tablet 10's packDescriptionAdequate Calcium in the blood is so vital to a wide variety of bodily functions that our internal biochemistry will not tolerate a deficiency even for short periods. Clinical evidence suggests thatCalcium is useful for the prevention and treatment of Osteoporosis and associated fractures. Vitamin D is also essential for healthy bones as it aids in Calcium absorption from the GI tract. In addition to this it stimulates bone formation. Clinical studies also show that Calcium and Vitamin D has synergistic effects on bone growth as well as in Osteoporosis and fracture prevention.Indications- In the treatment and prevention of Calcium and Vitamin-D deficiency- In the treatment and prevention of osteoporosis as an adjunct to other specific therapyDosage & Administration Adolescents and Adults: 1 tablet once or twice a dayChildren: 1 tablet once a dayDissolve FizyCal-D® effervescent tablet in a glass of water and drink immediately. Do not swallow or chew the tablet.Side Effects- Very rare: Serious Allergic reaction such as swelling of the face, lips, tongues and throat- Rare: Hyperecaicaemia, Hypercalciuria- Common (less serious): Nausea, Vomiting, Diarrhea, Abdominal pain, constipation, flatulence, bloating, itching, redness/ burning of the skinPrecautionsPatient with a history of renal stones urinary calcium excretion should be measured to exclude Hypercalciuria. During long-term administration of FizyCal-D regular blood and urine calcium levels as well as kidney function should be monitored regularly. Consultation with physician should be required while using other Calcium and Vitamin-D preparation, having previous history of kidney disorder and certain lung diseases e.g. Sarcoidosis/ Besnier-Boeck disease.Use in Pregnancy & LactationFizyCal-D effervescent tablets can be used during pregnancy, in case of a calcium and vitamin D deficiency. However, for supplementation starting during the third trimester of pregnancy, the daily intake should not exceed 1500 mg calcium and 1000 IU vitamin D. FizyCal-D® effervescent tablets can be used during breast-feeding.Drug InteractionFizyCal-D can interact with certain medications if taken at the same time. Physician advocacy should be required while using cardiac glycosides, thiazide diuretics or corticosteroids. In case of oral bisphosphonates and sodium fluoride, the drug should be taken at least 3 hrs later of administration of these drugs. FizyCal-D® should be taken 1 to 2 hrs before or 4 to 6 hrs after taking certain medications e.g. Tetracycline, cholestyramine or laxatives.Over DoseSymptoms of over dose may include nausea and vomiting, extreme thirst and constipation. The most serious consequence of acute chronic overdose is hypocalcaemia due to Vitamin D toxicity.StorageStore FizyCal-D at a cool and dry place and protect it from light and moisture. Keep out of reach of children. Keep the container tightly closed...
IndicationsCalcium Folinate is indicated in:To diminish the toxicity and counteract the effect of impaired Methotrexate eliminationTo treat the Megaloblastic anemia due to folate deficiency, as in sprue, nutritional deficiencyTo treat the Megaloblastic anemia of pregnancy and infancyTherapeutic ClassSupportive Care TherapyDescriptionCalcium Folinate is a Calcium salt of Folinic acid (citrovorum factor), is a mixture of the diastereoisomers of the 5-formyl derivative of Tetrahydrofolic acid. It is a metabolite of Folic acid and an essential coenzyme for nucleic acid synthesis used in cytotoxic therapy.PharmacologyFolinic acid is a 5-formyl derivative of tetrahydrofolic acid. It is readily converted to other reduced folic acid derivatives (e.g., tetrahydrofolate), thus has vitamin activity equivalent to that of folic acid. Since it does not require the action of dihydrofolate reductase for its conversion, its function as a vitamin is unaffected by inhibition of this enzyme by drugs such as methotrexate. This is the classical view of folinic acid rescue therapy.In 1980s, however, folinic acid was found to reactivate the dihydrofolate reductase itself even when methotrexate exists. Although the mechanism is not very clear, the polyglutamylation of methotrexate and dihydrofolate in malignant cells is considered to play an important role in the selective reactivation of dihydrofolate reductase by folinic acid in normal cells.Folinic acid, therefore, allows for some purine/pyrimidine synthesis to occur in the presence of dihydrofolate reductase inhibition, so some normal DNA replication processes can proceed.Dosage & AdministrationOral-Reduction of harmful effects of folic acid antagonists such as. Methotrexate, Trimethoprime etc.: The dose is usually one 15 mg tablet every 6 hours for 2 to 3 days.Megaloblastic anemia: In the treatment of Megaloblastic anemia, the dose is one 15 mg tablet daily.Intravenous-Adjunct to fluorouracil in colorectal cancer: 200 mg/m2 BSA by slow IV inj over at least 3 min followed by 370 mg/m2 fluorouracil by IV inj. Treatment is given for 5 consecutive days and repeated at intervals of 28 days for 2 courses. Subsequently, may repeat at 4-5 wkly intervals if the patient has recovered completely from the toxic effects of the prior treatment course.Intramuscular-Folate-deficient megaloblastic anaemia: Up to 1 mg/day.ContraindicationsCalcium Folinate therapy is contraindicated in known hypersensitivity to Calcium Folinate, or to any components of the product formulation. Pernicious anemia or other Megaloblastic anemia where Vitamin B12 is deficientSide EffectsAllergic reaction - one may experience a sudden itchy rash (hives), swelling of the hands, feet, ankles, face, lips, mouth or throat (which may cause difficulty in swallowing or breathing)Pregnancy & LactationThere are no adequate and well-controlled clinical studies conducted in pregnant or breastfeeding women. It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Calcium Folinate is administered to a nursing mother.Precautions & WarningsCalcium Folinate treatment may mask pernicious anemia and other Megaloblastic anemia resulting from vitamin B12 deficiency.Calcium Folinate should only be used with 5-fluorouracil or Methotrexate under the direct supervision of a clinician experienced in the use of cancer chemotherapeutic agents.Many cytotoxic medicinal products – direct or indirect DNA synthesis inhibitors – lead to macrocytosis (hydroxycarbamide, cytarabine, mercaptopurine, thioguanine). Such macrocytosis should not be treated with folinic acid.In epileptic patients treated with Phenobarbital, Phenytoin, Primidone, and Succinimides, there is a risk to increase the frequency of seizures due to a decrease of plasma concentrations of anti-epileptic drug.Overdose EffectsThere have been no reported sequelae in patients who have received significantly more Calcium Folinate than the recommended dosage. However, excessive amounts of Calcium Folinate may nullify the chemotherapeutic effect of folic acid antagonists...
DescriptionIntraCal® contains Calcium Orotate, a calcium supplement with a functional amino acid chelating ligand - orotic acid. Orotic acid assists the transport of calcium through cellular membrane structures, facilitating the intracellular uptake of calcium, particularly in bone. Calcium Orotate also helps in the maintenance of healthy cartilage. Furthermore, Orotate is involved in the synthesis of DNA (deoxyribonucleic acid) and RNA (ribonucleic acid). Calcium Orotate has the ability to penetrate complex cell membranes and it can be metabolized in cartilage.IndicationsIntraCal® is used -1. To prevent or treat low blood calcium levels in people who do notget enough calcium from diets.2. To fulfill the calcium deficiency or meet extra need of calcium inconditions like-• Osteomalacia• Rickets• Latent tetany• Postmenopausal osteoporosis• Senile osteoporosis• Juvenile osteoporosis• Drug induced osteoporosis(Phenytoin, Phenobarbital, or Prednisone)• Pregnancy and lactation• Premenstrual syndrome (PMS)• Hypoparathyroidism• Hip joint plastic surgery3. Acts against a number of inflammatory diseases like -• Arthritis• Multiple sclerosis• Spondylitis4. Helps in controlling weight by suppressing the habit of frequentappetite of chronic overeaters.5. It is also beneficial in reducing the effects of mood swings.6. Proved to be quite effective in cognitive enhancement.7. Protects the heart by enhancing the efficiency of cardiac muscles.Dosage & AdministrationAs an addition to the daily diet, 2-3 tablets are usually recommended with meal or as directed by health care professional.Side EffectsBloating and swelling in the abdomen are common side effects of Calcium Orotate. Constipation, nausea, vomiting, headache, increased thirst/urination, may occur infrequently.PrecautionsPrecaution is needed if the patient is allergic to calcium orotate. Before using this product in kidney disease, kidney stones, little or no stomach acid (achlorhydria), disease of the pancreas, a certain lung disease (sarcoidosis), difficulty absorbing nutrition from food (malabsorption syndrome) precaution is needed.Use in Pregnancy & LactationWomen who are pregnant and breast-feeding need more calcium. Pregnancy related high blood pressure is a common and serious risk for women and their babies, and taking supplemental forms of calcium orotate can help reduce this risk.Drug InteractionCalcium can decrease absorption of the following drugs when taken together- biphosphonates (e.g. alendronates), quinolone antibiotics (e.g. ciprofloxacin, levofloxacin) and tetracycline antibiotics (e.g. doxycycline, minocycline), levothyroxine, phenytoin (anticonvulsant), and tiludronate disodium (to treat Paget\\\'s disease). Thiazide-type diuretics can interact with calcium supplements, increasing the risks of hypercalcemia and hypercalciuria.StorageStore in a cool, dry place...
Marincal KIT 61'SDescriptionIbandronic AcidIbandronic Acid (Ibandronate Sodium Monohydrate) is a nitrogen- containing bisphosphonate that inhibits osteoclast-mediated bone resorption. The action of Ibandronate on bone tissue is based on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. Ibandronate inhibits osteoclast activity and reduces bone resorption and turnover. In postmenopausal women, it reduces the elevated rate of bone turnover, leading to, on average, a net gain in bone mass.Calcium (Coral) and Vitamin-DThe combination of Coral Calcium and Colecalciferol is composed of Calcium Carbonate with small amounts of Magnesium and other Trace minerals. Coral Calcium ensures better absorption than Calcium of other Calcium Carbonate origin due to its chemical structure that is very similar to the composition of human bone Calcium Carbonate. Vitamin-D aids in the absorption of Calcium from GI tract and helps to maintain Calcium balance in the body.IndicationsMarinCal Kit is indicated for the treatment and prevention of osteoporosisDosage & AdministrationDose: One tablet of Ibandronic Acid 150 mg once monthly on the same date of each month is recommended. To maximize clinical benefit of Ibandronic acid, two tablets of Calcium (Coral Source) 500 mg and Vitamin D 200 IU per day are usually recommended in divided dosage or as directed by the physician.Day 1Take the Ibandronic Acid tablet (as mentioned 'Day1' on the strip) on an empty stomach at least 60 minutes before the first food or drink (other than water) of the day or before taking any oral medication or supplementation including Calcium, Antacid and/ or VitaminsSwallow tablet whole with a glass of plain water while standing or sitting in an upright positionAvoid lying down for 60 minutesDo not chew or suck the tabletDay 2 -31:One tablet of Calcium and Vitamin D should be taken at the morning and at the evening after mealTablets should be taken in order as directed on the blister strip for ease of dose trackingSide EffectsPain or trouble with swallowing , Constipation, Chest pain, Diarrhea, Heartburn (esophagitis), Pain in extremities (arms or legs), Flatulence, Dyspepsia (upset stomachAllergic reaction.PrecautionsIbandronic AcidUpper Gastrointestinal Adverse Reactions: Ibandronic acid like other bisphosphonates administered orally may cause local irritation of the upper gastrointestinal mucosa. Because of these possible irritant effects, caution should be used when Ibandronic acid is given to patients with active upper gastrointestinal problems (such as known Barrett’s esophagus, dysphagia, other esophageal diseases, gastritis, duodenitis or ulcers).Hypocalcaemia and Mineral Metabolism: Treat hypocalcemia and other disturbances of bone and mineral metabolism before starting therapy.Musculoskeletal Pain: Severe and occasionally incapacitating bone, joint, and/or muscle pain has been reported in patients taking Ibandronic acid and other bisphosphonates.Jaw Osteonecrosis: Osteonecrosis, primarily in the jaw, has been reported in patients treated with bisphosphonates. Most cases have been in cancer patients undergoing dental procedures, but some have occurred in patients with postmenopausal osteoporosis or other diagnoses.Calcium (Coral) and Vitamin-DIn mild hypercalciuria reduction of dose is sufficient to return to normal serum Calcium concentration. Plasma and serum Calcium level should be monitored in mild to moderate renal impairment patients and also in case of long term use. Patients with renal stone or with such previous history should be recommended to increase their fluid intake.Use in Pregnancy & LactationPregnancy: Pregnancy category- C. There are no adequate and well-controlled studies in pregnant women. MarinCal kit should be used during pregnancy only if the potential benefit justifies the potential risk to the mother and fetus.Nursing mother: It is not known whether MarinCal kit is excreted in human milk.Because many drugs are excreted in human milk, caution should be exercised whenMarinCal kit is administered to a nursing woman. Pediatric patient: Safety and effectiveness in pediatric patients have not been established.Drug InteractionIbandronic AcidProducts containing calcium and other multivalent cations (such as aluminum, magnesium, iron), including milk, food, and antacids are likely to interfere with absorption of Ibandronate. It is also found to interact with H2 blockers such as Ranitidine in several clinical trials..Calcium (Coral) and Vitamin-DOral Calcium can reduce the absorption of tetracycline & fluoride preparations and minimum 3 hours’ time should be allowed between ingestion of these medications. Thiazide diuretics reduce the renal excretion of Calcium. Phenytoin, barbiturates, glucocorticoids may induce metabolism of Vitamin D. Concomitant intake of certain foods like spinach, cereals, milk and its derivatives may reduce the intestinal uptake of Calcium.Over DoseNo specific information is..