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Don A 15 mg Suppository

Don A 15 mg Suppository

Don A 15 SuppDESCRIPTIONDON-A (Domperidone) is a dopamine receptor (D2) antagonist. DON-A (Domperidone) is a selective peripheral dopamine antagonist at the D2 dopamine receptor in the Chemo-receptor Trigger Zone (CTZ) and stomach. DON-A (Domperidone) does not readily enter the central nervous system (the chemoreceptor trigger zone is considered to lie outside the blood brain barrier). DON-A (Domperidone) increases spontaneous gastric activity and antagonizes dopamine inhibition of gastric emptying. DON-A (Domperidone) has been shown to increase lower esophageal sphincter pressure and promotes esophageal and antral peristalsis and also increases pyloric dilatation. DON-A (Domperidone) increases the frequency, amplitude, duration of duodenal contraction and reduces the small bowel transit time. DON-A (Domperidone) has noacetylcholine like effect.COMPOSITIONDON-A Tablet: Each film-coated tablet contains Domperidone Maleate BP equivalent to Domperidone 10 mg.DON-A Suspension: Each 5 ml suspension contains Domperidone BP 5 mg.DON-A Paediatric Suspension: Each ml suspension contains Domperidone BP 1 mg.DON-A Paediatric Drops: Each ml contains Domperidone BP 5 mg.DON-A 15 Suppository : Each suppository contains Domperidone BP 15 mg.DON-A 30 Suppository : Each suppository contains Domperidone BP 30 mg.INDICATIONS1. Prevention and symptomatic relief of acute nausea and  vomiting in adults from any cause but specially- Cytotoxic – therapy Radio – therapy Nausea and vomiting associated with L-dopa and  bromocriptine treatment for parkinsonian patients Nausea associated with migraine attacks2. Stimulation of gut mobility Non-ulcer dyspepsia Esophageal reflux Reflux esophagitis Gastritis Speeding barium transit in "follow- through" radiological studies Diabetic gastroparesis3. Functional dyspepsia.DOSAGE AND ADMINISTRATIONDON-A (Domperidone) should be taken 15-30 minutes before a meal. The usual recommended oral dose is as follows:Tablet/ Suspension/ Paediatric drops :Adult: 10-20 mg (1-2 DON-A tablet or 10-20 ml DON-A suspension) every 4-8 hours.Elderly : Same as for adults.Children: 0.2-0.4 mg/kg body weight (2-4 ml suspension or 0.4-0.8 ml Paediatric drops/ 10 kg body weight) every 4-8 hours.By rectum in suppositories : Adults (including elderly) : 30-60 mg every 4-8 hours.Children : The maximum daily dose rectally in children’s is 30 mg for those weighting 10 to 25 kg. Dose may be divided throughout day if necessary. Maximum period of treatment is 12 weeks.OR AS DIRECTED BY THE PHYSICIAN.SIDE EFFECTSExtrapyramidal reactions are seen in 0.05% of patients in clinical studies. Domperidone may produce hyperprolactinemia (1.3%). This may result ingalactorrhea, breast enlargement, soreness and reduced libido. Dry mouth (1.9%), thirst, headache (1.2%), nervousness, drowsiness (0.4%), diarrhea (0.2%), skin rash and itch (0.1%) may all follow treatment with Domperidone.CONTRAINDICATIONSDomperidone is contraindicated to patients having known hypersensitivity to this drug and in case of neonates. Domperidone should not be used when gastrointestinal stimulation might be dangerous i.e. gastrointestinal haemorrhage, obstruction, perforation or immediately after surgery.PRECAUTIONSDomperidone should be used with absolute caution in case of children because there may be an increased risk of extrapyramidal reactions in young children because of an incompletely developed blood brain barrier.The safety of Domperidone has not been proven and it is, therefore, not recommended during pregnancy. Animal studies have not demonstrated teratogenic effect on the fetus. Domperidone may precipitate galactorrhea and improve postnatal lactation. It is secreted in breast milk but in very small quantities insufficient to be considered harmful.DRUG INTERACTIONSDomperidone may reduce the risk of hypoprolactinemic effect of bromocriptine. The action of Domperidone on Gl function may be antagonized by antimuscarinics and opioid analgesics.OVERDOSAGEThere are no reported cases of over dosage.SUPPLYDON-A Tablet: Each box contains 10 X 10 tablets in blister strip.DON-A Suspension: Bottle containing 60 ml suspension.DON-A Paediatric Suspension: Bottle containing 30 ml suspension with a dropper.DON-A Paediatric Drops: Bottle containing 15 ml drops with a dropper.DON-A 15 Suppository : Each Box contains 2 X 5 suppositories in blister strips.DON-A 30 Suppository : Each Box contains 2 X 5 suppositories in blister strips...

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