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Naligram 50 ml Suspension

Naligram 50 ml Suspension

Naligram 50 ml SuspensionDESCRIPTIONNALIGRAM (Nalidixic Acid) is a bactericidal antimicrobial agent used mainly in the treatment and prophylaxis of urinary tract infections caused by Gram-negative pathogen specially E. coli. It is effective against most Gram-negative bacilli with the notable exception ofPseudomonas species. NALIGRAM (Nalidixic Acid) exerts its antibacterial activity by inhibiting DNA replication in the bacterial cell by inhibition of the enzyme DNA gyrase. It is considered as the first line treatment in cases of multiresistant Shigella infections. NALIGRAM(Nalidixic Acid) shows high clinical and bacteriological cure rates in patients with bloody diarrhea caused by multiresistant Shigella and proved to be a childhood safe antimicrobial in the therapeutic dosage range.COMPOSITIONTablet : Each tablet contains Nalidixic Acid BP 500 mg.Suspension : Each 5 ml suspension contains Nalidixic Acid BP 300 mg.INDICATIONSl Shigellosisl Salmonellosisl Acute and chronic urinary tract infections.DOSAGE AND ADMINISTRATIONAdults : 2 tablets (1g) in every 6 hours for 7 days; the dose is reduced in chronic infections to 1 tablet (500 mg) every 6 hours.Children : Children over three months of age initial therapy is 55 mg/kg body weight/day, administered in 4 equally divided doses. For prolonged therapy, the total daily dose may be reduced to 33 mg/kg body weight/day.OR AS DIRECTED BY THE PHYSICIAN.SIDE EFFECTSOccasionally gastrointestinal hyper-sensitivity, fever, eosinophilia, photosensitivity and neurological distur-bances like malaise, drowsiness, dizziness may occur. Mild leukopenia, thrombocytopenia, hemolytic anemia may also be observed.CONTRAINDICATIONSNalidixic Acid is contraindicated in children below 3 months of age. It is also contraindicated in epileptic patients and in patients with known hypersensitivity to Nalidixic Acid.PRECAUTIONSNalidixic Acid should not be administered with nitrofurantoin and anticoagulant. In case of renal failure the plasma half life may be as long as 21 hours instead of normal 8 hours. Overdosing of NalidixicAcid in children may develop intracranial pressure, therefore caution should be taken in case of paediatric treatment. Nalidixic Acid should be used after 48-72 hours from the onset of infection in cases of chronic shigellosis to avoid development of bacterial resistance.DRUG INTERACTIONSAnticoagulant effect of nicoumalone and warfarin and toxicity of melphalan is enhanced by Nalidixic Acid. Probenecid reduces excretion of Nalidixic Acid.SUPPLYTablet : Each box contains 10 x 10 tablets in strips.Suspension : Bottles contain 50 ml suspension with a measuring spoon...

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