Olmesan 101. What Olmesan® is and what it is used for?Olmesan® (Olmesartan Medoxomil), a prodrug, is hydrolyzed to Olmesartan during absorption from the gastrointestinal tract. Olmesartan is a selective AT1 subtype angiotensin II receptor antagonist. Olmesan® (olmesartan Medoxomil) is indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents.2. Before you take Olmesan®Let your doctor know if you have these, or any other, medical conditions:Have less urine than normal or if you cannot urinateAre allergic to other sulfonamide type medicinesHave severe kidney diseaseIf you take Olmesan®, tell your doctor if you also take:Water pills (diuretics)Other medicines for high blood pressure or a heart problemPotassium supplements or a salt substitute that contains potassiumPain or arthritis medicines, such as aspirin and nonsteroidal anti-inflammatory drugSimvastatin, a cholesterol-lowering drugLithium for certain types of depressionDo not take this medicine and tell your doctor if:You are taking medicine that contains aliskiren and you have diabetes or kidney problems.Before taking Olmesan®, tell your doctor if you are pregnant or plan to become pregnant. Also tell your doctor if you are breast-feeding or plan to breast-feed. You and your doctor should decide if you will take Olmesan® or breast-feed. You should not do both.Take special care with Olmesan®Fetal/Neonatal Morbidity and Mortality: When pregnancy is detected, this combination should be discontinued as soon as possible.Hypotension in Volume- or Salt-Depleted Patients: Symptomatic hypotension may occur after initiation of treatment.Patients with Hepatic Impairment: Caution should be exercised when administering the drug to patients with severe hepatic impairment.Check with your doctor before taking this medicine if:Before taking Olmesan®, tell your doctor if you are pregnant or plan to become pregnant. Also tell your doctor if you are breast-feeding or plan to breast-feed. You and your doctor should decide if you will take Olmesan® or breast-feed. You should not do both.Taking other medicinesSome of your other medicines and Olmesan® could effect each other. This may cause serious side effects. Take Olmesan® as prescribed by your doctor. Talk with your doctor before you stop taking Olmesan®.Pregnancy and breast-feedingWhen pregnancy is detected, discontinue Olmesan® as soon as possible. When used in pregnancy during the second and third trimesters, drugs that act directly on the renin-angiotensin system can cause injury and even death to the developing fetus.Nursing Mothers: Because of the potential for adverse effects on the nursing infant, a decision should be made whether to discontinue nursing or discontinue the drug.3. How to take Olmesan®?Taking this medicine (Do not need to change)Always use Olmesan® exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure.How much to take?Dosage must be individualized. The usual recommended starting dose of Olmesartan Medoxomil 20 mg once daily when used as monotherapy in patients who are not volume-contracted. For patients requiring further reduction in blood pressure after 2 weeks of therapy, the dose of Olmesartan Medoxomil may be increased to 40 mg. Doses above 40 mg do not appear to have greater effect. Twice-daily dosing offers no advantage over the same total dose given once daily.Olmesan® may be taken with or without food. Olmesan® may be administered with other antihypertensive agents.If you take more Olmesan® than you shouldIf you have too much of this medicine, talk to your doctor straight away.If you forget to take Olmesan®If you forget to take a dose, take it as soon as you remember it. However, if it is nearly time for the next dose, skip the missed dose. Do not take a double dose to make up for a forgotten dose.If you stop taking Olmesan®Do not stop taking this medicine without talking to your doctor. You should not stop taking Olmesan® just because you feel better. This is because the problem may come back or get worse again.If you have any further questions on the use of this product, ask your doctor or pharmacist.4. Possible side effectsGet emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.In rare cases, Olmesartan can cause a condition that result in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.Tell your doctor if any of the side effects gets serious or lasts longer than a few days, or if you notice any side effects not listed in this leaflet.5. How to store Tearon?Store in a cool and dry place, away from light.Keep out of reach of children..