Lincocin-150 mg cap
Clindamycin is a lincosamide antibiotic used in the treatment of infections caused by susceptible microorganisms. It is a semisynthetic antibiotic produced from lincomycin.
Clindamycin is rapidly absorbed after oral administration. Concomitant administration of food does not appreciably modify the serum concentrations. Serum level studies following multiple doses of
Clindamycin for up to 14 days show no evidence of accumulation or altered metabolism of drug. Clindamycin is widely distributed in body fluids and tissues (including bones). The average biological half-life is 2.4 hours. No significant levels of Clindamycin are attained in the cerebrospinal fluid (even in the presence of inflamed meninges).
Clindamycin is bacteriostatic. It inhibits bacterial protein synthesis by binding to the 50S subunit of the ribosome. It has activity against
Aerobic gram-positive cocci, including: Staphylococcus aureus,
Staphylococcus epidermidis (penicillinase and non-penicillinase
producing strains), Streptococci, Pneumococci. Anaerobic gramnegative bacilli, including: Bacteroides species, Fusobacterium species. Anaerobic gram-positive non-spore forming bacilli including:
Propionibacterium species, Eubacterium species, Actinomyces species. Anaerobic and microaerophilic gram-positive cocci, including:
Peptococcus species, Peptostreptococcus species, Microaerophilic streptococci, C. perferinges, B. fragilis.
LINCOCIN 150: Each capsule contains Clindamycin Hydrochloride BP equivalent to Clindamycin 150 mg.
LINCOCIN 300: Each capsule contains Clindamycin Hydrochloride BP equivalent to Clindamycin 300 mg.
Serious Respiratory tract infections including bronchitis, emphysema, pneumonia and lung abscess.
Serious skin and soft tissue infection including Acne
Bone and bone joint infections including osteomyelitis and septic arthritis.
Intra-abdominal infections such as peritonitis intra-abdominal abscess.
Infection of genital tract infection as endometritis, nongonococcol tuboovarian abscess, Pelvic Infections, pelvic cellulites and post surgical vaginal cuff infection.
Septicemia and endocarditis.
Dental infection such as periodontal abscess and periodontitis.
It is also used as alternative therapy for infection of penicillin-allergic patients caused by penicillin susceptible microorganisms.
As combination with Quinine sulfate for the treatment of uncomplicated chloroquine-resistant Plasmodium falciporum
Clindamycin can also be used for infections associated with meticillin-resistant staphylococcus aureous (MRSA) in bronchiectasis, bone and bone joint infections and skin and soft tissue infections.
DOSAGE AND ADMINISTRATION
Adult: Serious infections: 150 to 300 mg every 6 hours. More severe infections: 300 to 450 mg every 6 hours.
Serious infections: 8 to 16 mg/kg/day divided into three or four equal doses.
More severe infections: 16 to 20 mg/kg/day divided into three or four equal doses.
To avoid the possibility of esophageal irritation, LINCOCIN Capsules should be taken with a full glass of water.
Or as directed by the physician.
Side effects include diarrhoea (discontinue treatment), abdominal discomfort, Oesophagitis, Oesophageal ulcers, taste disturbances, nausea, vomiting, antibiotic-associated colitis, jaundice, rash, pruritis and urticaria.
Clindamycin is contraindicated in individuals with a history of hypersensitivity to preparations containing clindamycin.
Discontinue immediately if diarrhoea or colitis develops. Monitor liver and renal function if treatment exceeds 10 days. Clindamycin occasionally results in overgrowth of nonsusceptible organismsparticularly yeast. Appropriate measures should be taken if super infections occur.
USE IN CHILDREN
When Clindamycin is administered to the pediatric population (birth to 16 years), appropriate monitoring of organ system functions is desirable.
USE IN PREGNANCY AND LACTATION
Pregnancy category B. The drug should be used in pregnancy only if clearly needed.
Clindamycin has been reported to appear in breast milk. So it is not recommended for lactating mother if not clearly needed.
USE IN ELDERLY
Patients should be carefully monitored for the development of diarrhea.
Antagonism has been demonstrated between Clindamycin and
Erythromycin in vitro. Because of possible clinical significance, these two drugs should not be administered concurrently.
LINCOCIN 150: Each box contains 3X10 capsules in blister strips.
LINCOCIN 300: Each box contains 3X10 capsules in blister strips.