1. Intravenous injection: 1 mg injection repeated every 2-3 minutes as necessary.
2. Endotracheal: 2-3 mg via an endotracheal tube, repeated as necessary.
3. Intracardiac injection: 0.1 to 1 mg, direct into the atrium of the heart.
4. Intraspinal use: Usual dose is 0.2 to 0.4 mg added to anesthetic
spinal fluid mixture (to prolong anesthetic action by limiting
Anaphylaxis, asthma or severe bronchospasm: Adult dose is 0.25 - 0.5 mg.
It may be repeated at 5 minutes intervals until perfusion and
respiratory status normalizes. In case of dose dilution: 1 mg of
Adrenaline to be diluted in 9 ml Normal Saline.
Children: Intravenous injection: Initially 10 mcg/kg body weight, not to
exceed 250 mcg. May be repeated every 3-5 minutes if necessary.
Subsequent doses should be 100 mcg/kg.
restlessness, dizziness, headache, palpitations, rapid pulse, tremors,
weakness and coldness of the extremities may be reported even with small
doses and especially when given in conjunction with local anaesthetics.
solution should not be used if it is pinkish or darker than slightly
yellow or if it contains a precipitate. Adrenaline is readily destroyed
by alkalies and oxidizing agents. In the latter category are Oxygen,
Chlorine, Iodine, Permanganates, Chromates, Nitrites and salts of easily
reducible metals, especially Iron. Adrenaline should not be mixed with
Sodium bicarbonate; the solution is oxidised to adrenochrome and then
Special warnings and precautions for use
Administer slowly with caution to elderly patients and to patients with
ischemic heart disease, hypertension, diabetes mellitus, hyperthyroidism
or psychoneurosis. Use with extreme caution in patients with
long-standing bronchial asthma and emphysema who have developed
degenerative heart disease. Anginal pain may be induced when coronary
insufficiency is present.
arteriosclerosis, coronary disease and hyperthyroidism. Not to be given
to patients taking monoamine oxidase inhibitors.
Use in Pregnancy & Lactation
Category C. It crosses the placenta and is excreted in breast milk.
Adrenaline should only be used in pregnancy if the potential benefits
outweigh the risks to the fetus.
Lactating mothers: It is excreted in breast milk and therefore
Adrenaline is not recommended for use during lactation because of the
risk of adverse effects of infants.
of Adrenaline with excessive doses of digitalis, mercurial diuretics or
other drugs that sensitize the heart to arrhythmias is not recommended.
The adverse effects of Adrenaline may be potentiated by tricyclic
antidepressants; certain antihistamines; e.g, Diphenhydramine,
Tripelennamine, Chlorpheniramine and L-thyroxine Sodium.
Cardiac arrhythmia leading to ventricular fibrillation, severe
hypertension leading to pulmonary edema and cerebral hemorrhage.
Treatment: Combined alpha and beta-adrenergic blocking agents such as
Labetalol may counteract the effects of adrenaline, or a beta-blocking
agent may be used to treat any supraventricular arrhythmias and
Phentolamine to control the alpha-mediated effects on the peripheral
circulation. Rapidly acting vasodilators such as nitrates and Sodium
Nitroprusside may also be helpful. Immediate resuscitation support must
Store below 25 °C. Protect from light.
Adrinor Injection: Each commercial box contains 5 amber ampoules.