Clobetasol Propionate has both local anti-inflammatory and immunosuppressive activity. The drug blocks the effect of macrophage migration inhibitory factor and decreases the activation of plasminogen to plasmin. It inhibits phospholipase A2 activity via formation of lipocortin which reduces the formation of prostaglandins and leucotrienes in the local tissues. Salicylic acid is a keratolytic agent. It encourages exfoliation of the skin and opening up of the plugged follicles, which helps re-establish the normal skin-cell replacement cycle.