Arotril (Clonazepam), a derivative of benzodiazepine is mainly used as anticonvulsant drug. Clonazepam brings about direct inhibition of cortical and sub-cortical epileptogenic focus and thus prevents the formation of convulsive activity. It displays several pharmacological properties, which are characteristics of benzodiazepine class of drugs. At the spinal cord level clonazepam depresses more reflux pathways and potentiates presynaptic inhibition of GABA in the CNS. Overcompensatory excitation processes are thereby reduced via negative feedback without substantiation of other physiologic neuronal activity.