Migraine

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Capsule Libidex-5%

Capsule Libidex

 Tk.750.00/=  Tk.712.00/=
Contour Plus 25 strips-10%

Contour Plus 25 strips

 Tk.625.00/=  Tk.562.00/=
Contour Plus One meter-10%

Contour Plus One meter

 Tk.2,000.00/=  Tk.1,800.00/=
Mask KN95-71%

Mask KN95

 Tk.35.00/=  Tk.10.00/=


Piramed 25 mg Tablet

Piramed 25 mg Tablet

Indication: This drug is used to treat epilepsy in both children and adults. In children it is also indicated for treatment of Lennox-Gastaut syndrome (a disorder that causes seizures and developmental delay). It is now most frequently prescribed for the prevention of migraines. It has been used by psychiatrists to treat bipolar disorder and alcoholism. The drug is also used to treat Post Traumatic Stress Disorder. Studies suggest that Topiramate is effective against infantile spasms. Monotherapy in Epilepsy: Topiramate is indicated as initial monotherapy in patients of 10 years of age and older with partial onset or primary generalized tonic-clonic seizures. Adjunctive Therapy in Epilepsy: Topiramate is indicated as adjunctive therapy for adults and pediatric patients ages 2-16 years with partial onset seizures, or primary generalized tonic-clonic seizures, and in patients 2 years of age and older with seizures associated with Lennox-Gastaut syndrome. Migraine: Topiramate is indicated for adults for the prophylaxis of migraine headache...

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Rivotril 0.5mg Tab

Rivotril 0.5mg Tab

Rivotril 0.5mg Tab..

Tk.8.00/=

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Rivotril 1mg Tab

Rivotril 1mg Tab

Rivotril 2mg Tab..

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Rivotril 2mg Tab

Rivotril 2mg Tab

Rivotril 2mg Tab..

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Tolmic 200 mg Tablet

Tolmic 200 mg Tablet

1. What Tolmic® is and what it is used for?Tolmic® (Tolfenamic Acid) is an NSAID with anti-inflammatory, analgesic and antipyretic effects. It is a prostaglandin synthesis inhibitor and a leukotriene synthesis inhibitor. Tolmic® is indicated for the symptoms of migraine. 2. Before you take Tolmic® Do not take this medicine and tell your doctor if: Before taking Tolmic®, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. As is the case with other NSAIDs, tolfenamic acid should be used with caution in patients with a history of gastrointestinal ulceration, or impaired liver or kidney function.Take special care with Tolmic® Check with your doctor before taking this medicine if: Active peptic ulceration. Significantly impaired kidney or liver function. Tolfenamic Acid is contraindicated in patients in whom attacks of asthma, urticaria or acute rhinitis are precipitated by aspirin or other non-steroidal anti-inflammatory agents. Taking other medicines In patients treated with anticoagulants, close monitoring of blood coagulation is recommended. Diuretics: The effect of loop diuretics may be reduced. Lithium : The effect of lithium may be increased. Pregnancy and breast-feeding Reproduction studies in animals have not shown any signs of fetal damage. Controlled studies in pregnant women are not available. As is the case with the use of other NSAIDs, tolfenamic acid should not be given in the last trimester, due to risks of premature closure of the ductus arteriosus and prolonged parturition. Tolfenamic acid is excreted to such a very small extent in mothers' milk that it should be without risk to the breast-fed baby. 3. How to take Tolmic®? For acute attacks: 200 mg when the first symptoms of migraine appear. The treatment can be repeated once after 1-2 hours if a satisfactory response is not obtained If you forget to take Tolmic® If you forget to take a dose, take it as soon as you remember it. If it is almost time for your next dose, do not take the missed dose. Take the next dose on time If you stop taking Tolmic® Do not stop taking this medicine without talking to your doctor. You should not stop taking Tolmic® just because you feel better. This is because the problem may come back or get worse again. If you have any further questions on the use of this product, ask your doctor or pharmacist. 4. Possible side effects Like all medicines, Tolmic® can cause side effects, although not everybody gets them. Tolfenamic Acid is well tolerated at the recommended dosage and seldom causes side effects which include diarrhea, nausea, epigastric pain, vomiting, urticaria, allergic skin reactions etc. 5. How to store Tolmic®? Store in a cool and dry place, away from light. Keep out of reach of children Tolmic Prescribing InformationLocated in: Muscloskeletal..

Tk.8.03/=

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Tomide 2.5 mg Tab

Tomide 2.5 mg Tab

IndicationsTorasemide is indicated for the management of edema of cardiac, renal and hepatic origin.The management of hypertension, as a sole therapeutic agent or in combination with other classes of antihypertensive agents.PharmacologyTorasemide inhibits the Na+/K+/2CI– carrier system (via interference of the chloride binding site) in the lumen of the thick ascending portion of the loop of Henle, resulting in a decrease in reabsorption of sodium and chloride. This results in an increase in the rate of delivery of tubular fluid and electrolytes to the distal sites of hydrogen and potassium ion secretion, while plasma volume contraction increases aldosterone production. The increased delivery and high aldosterone levels promote sodium reabsorption at the distal tubules, and By increasing the delivery of sodium to the distal renal tubule, torasemide indirectly increases potassium excretion via the sodium-potassium exchange mechanism. Torasemide’s effects in other segments of the nephron have not been demonstrated. Thus torasemide increases the urinary excretion of sodium, chloride, and water, but it does not significantly alter glomerular filtration rate, renal plasma flow, or acid-base balance. Torasemide’s effects as a antihypertensive are due to its diuretic actions. By reducing extracellular and plasma fluid volume, blood pressure is reduced temporarily, and cardiac output also decreases.Dosage & AdministrationCongestive heart failure: The usual initial oral dose is 10 mg or 20 mg once daily. If the diuretic response is inadequate, the dose should be titrated upward by approximately doubling until the desired diuretic response is obtained. Single doses higher than 200 mg have not been adequately studied.Chronic renal failure: The usual initial oral dose is 20 mg once daily. lf the diuretic response is inadequate, the dose should be titrated upward by approximately doubling until the desired diuretic response is obtained. Single doses higher than 200mg have not been adequately studied.Hepatic cirrhosis: The usual initial oral dose is 5 mg or 10 mg once daily, administered together with an aldosterone antagonist or a potassium sparing diuretic. If the diuretic response is inadequate, the dose should be titrated upward by approximately doubling until the desired diuretic response is obtained. Single doses higher than 40 mg have not been adequately studied. Chronic use of any diuretic in hepatic disease has not been studied in adequate and well-controlled trials.Hypertension: The usual initial oral dose is 2.5-5 mg once daily. If the 5 mg dose does not provide adequate reduction of blood pressure within 4 to 6 weeks, the dose may be increased to 10 mg once daily. If the response to 10 mg is insufficient, an additional antihypertensive should be added to the treatment regimen.InteractionIncreased risk of severe hypokalaemia with amphotercin B, corticosteroids, carbenoxolone, hypokalaemia-causing medications. Increased risk of lithium toxicity. Increased potential for ototoxicity and nephrotoxicity with nephrotoxic or ototoxic medications e.g. aminoglycosides. High dose salicylates may increase the risk of salicylate toxicity. Increased risk of toxicity with digoxin. Reduced diuretic effect with NSAIDs. Increased risk of hypotension with antihypertensives.ContraindicationsTorasemide is contraindicated in patients with known hypersensitivity to torasemide and other sulfonyl ureas. It is also contraindicated in patients who are anuric.Side EffectsUsually torasemide is well tolerated. However, a few side effects like dry mouth, dizziness, tiredness, skin rash, diarrhea, constipation, nausea, vomiting, orthostatic hypotention and muscle cramp may occur. All side effects usually are mild and transient.Pregnancy & LactationPregnancy: Adequate and well controlled studies of torasemide have not been carried out in pregnant woman. Because animal reproduction studies are not always predictive of human response, torasemide can be used during pregnancy only if clearly needed.Nursing Mother: lt is not known whether torasemide is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when torasemide is administered to a nursing mother.PrecautionsPrecautions should be taken while torasemide is administered in the conditions like diabetes, gout, hypotension and liver failure.Overdose EffectsThere is no human experience of overdoses of torasemide, but the signs and symptoms of overdosage can be anticipated to be those of excessive pharmacological effect: dehydration, hypovolemia, hypotension and hypokalemia. Treatment of overdose should consist of fluid and electrolyte supplement...

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Topirva 25 Tab

Topirva 25 Tab

Topirva 25 TabDescriptionTopiramate is a sulfamate substituted monosaccharide. Topiramate has the molecular formula C12H21NO8S and a molecular weight of 339.37. Topiramate is a white crystalline powder with a bitter taste. The precise mechanisms by which Topiramate exerts its anticonvulsant and migraine prophylaxis effects are unknown. Electrophysiological and biochemical evidence suggests that Topiramate, at pharmacologically relevant concentrations, blocks voltage-dependent sodium channels, augments the activity of the neurotransmitter Gamma Amino Butyrate at some subtypes of the GABA-A receptor, antagonizes the AMPA / kainate subtype of the glutamate receptor, and inhibits the carbonic anhydrase enzyme, particularly isoenzymes II and IV.IndicationsMonotherapy EpilepsyTopiramate tablets are indicated as initial monotherapy in patients 10 years of age and older with partial onset or primary generalized tonic-clonic seizures.Adjunctive Therapy EpilepsyTopiramate tablets are indicated as adjunctive therapy for adults and pediatric patients (ages 2-16 years) with partial onset seizures, or primary generalized tonic-clonic seizures and in patients 2 years of age and older with seizures associated with Lennox-Gastaut syndrome.MigraineTopiramate tablets are indicated for adults for the prophylaxis of migraine headache. The usefulness of Topiramate in the acute treatment of migraine headache has not been studied.Dosage & AdministrationIn order to avoid early side-effects (e.g. cognitive dysfunction) the initial dose normally is low and increased in slow steps. The usual initial dose is 25 to 50mg daily in 2 single doses. Recommended increments are 25 to 50mg every 1 or 2 weeks. Common doses for maintenance treatment are 100 to 200mg daily. The highest dose possible is 1,000mg daily in divided doses.EpilepsyMonotherapy UseThe recommended maximum dose for Topiramate monotherapy in adults and children 10 years of age and older is 400 mg/day in two divided doses.Adjunctive Therapy UseAdults (17 Years of Age and Over): Partial Seizures, Primary Generalized Tonic-Clonic Seizures, or Lennox-Gastaut Syndrome - The recommended total daily dose of Topiramate as adjunctive therapy in adults with partial seizures is 200-400 mg/day in two divided doses, and 400 mg/day in two divided doses as adjunctive treatment in adults with primary generalized tonic-clonic seizures. It is recommended that therapy be initiated at 25-50 mg/day followed by titration to an effective dose in increments of 25-50 mg/week. Titrating in increments of 25 mg/week may delay the time to reach an effective dose.Pediatric Patients (Age 2 - 16 Years): Partial Seizures, Primary Generalized Tonic-Clonic Seizures, or Lennox-Gastaut Syndrome - The recommended total daily dose of Topiramate as adjunctive therapy for patients with partial seizures, primary generalized tonic-clonic seizures, or seizures associated with Lennox-Gastaut Syndrome is approximately 5 to 9 mg/kg/day in two divided doses. Titration should begin at 25 mg (or less, based on a range of 1 to 3 mg/kg/day) nightly for the first week. The dosage should then be increased at 1 or 2 weeks intervals by increments of 1 to 3 mg/kg/day (administered in two divided doses), to achieve optimal clinical response.MigraineThe recommended total daily dose of Topiramate as treatment for prophylaxis of migraine headache is 100 mg/day administered in two divided doses.Pediatric Use: The safety of Topiramate has not been established in case of children under two.Side EffectsPatients may experience hypoglycemia while taking this medication. Topiramate may cause other side effects such as slow thinking or movements, difficulty concentrating, speech problems, specially difficulty thinking of specific words, memory problems, lack of coordination, trouble walking, confusion, nervousness, aggressive behavior depression, headache, extreme tiredness.PrecautionsThe major route of elimination of unchanged Topiramate and its metabolites is via the kidney. Dosage adjustment may be required in patients with reduced renal function. In hepatically impaired patients, Topiramate should be administered with caution as the clearance of Topiramate may be decreased.Use in Pregnancy & LactationPregnancy: Topiramate is pregnancy Category C. Topiramate should not be given to a pregnant woman.Nursing Mothers : It is not known whether this drug is excreted in human milk and so caution should be exercised when Topiramate is administered to a nursing woman.Drug InteractionDrugs like valproic acid, carbonic anhydrase (e.g. Acetazolamide), enzyme inducers (e.g. Carbamazepine), Phenytoin and Alcohol should be used with caution while taking Topiramate...

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Topirva 50 Tab

Topirva 50 Tab

Topirva 50 TabDescriptionTopiramate is a sulfamate substituted monosaccharide. Topiramate has the molecular formula C12H21NO8S and a molecular weight of 339.37. Topiramate is a white crystalline powder with a bitter taste. The precise mechanisms by which Topiramate exerts its anticonvulsant and migraine prophylaxis effects are unknown. Electrophysiological and biochemical evidence suggests that Topiramate, at pharmacologically relevant concentrations, blocks voltage-dependent sodium channels, augments the activity of the neurotransmitter Gamma Amino Butyrate at some subtypes of the GABA-A receptor, antagonizes the AMPA / kainate subtype of the glutamate receptor, and inhibits the carbonic anhydrase enzyme, particularly isoenzymes II and IV.IndicationsMonotherapy EpilepsyTopiramate tablets are indicated as initial monotherapy in patients 10 years of age and older with partial onset or primary generalized tonic-clonic seizures.Adjunctive Therapy EpilepsyTopiramate tablets are indicated as adjunctive therapy for adults and pediatric patients (ages 2-16 years) with partial onset seizures, or primary generalized tonic-clonic seizures and in patients 2 years of age and older with seizures associated with Lennox-Gastaut syndrome.MigraineTopiramate tablets are indicated for adults for the prophylaxis of migraine headache. The usefulness of Topiramate in the acute treatment of migraine headache has not been studied.Dosage & AdministrationIn order to avoid early side-effects (e.g. cognitive dysfunction) the initial dose normally is low and increased in slow steps. The usual initial dose is 25 to 50mg daily in 2 single doses. Recommended increments are 25 to 50mg every 1 or 2 weeks. Common doses for maintenance treatment are 100 to 200mg daily. The highest dose possible is 1,000mg daily in divided doses.EpilepsyMonotherapy UseThe recommended maximum dose for Topiramate monotherapy in adults and children 10 years of age and older is 400 mg/day in two divided doses.Adjunctive Therapy UseAdults (17 Years of Age and Over): Partial Seizures, Primary Generalized Tonic-Clonic Seizures, or Lennox-Gastaut Syndrome - The recommended total daily dose of Topiramate as adjunctive therapy in adults with partial seizures is 200-400 mg/day in two divided doses, and 400 mg/day in two divided doses as adjunctive treatment in adults with primary generalized tonic-clonic seizures. It is recommended that therapy be initiated at 25-50 mg/day followed by titration to an effective dose in increments of 25-50 mg/week. Titrating in increments of 25 mg/week may delay the time to reach an effective dose.Pediatric Patients (Age 2 - 16 Years): Partial Seizures, Primary Generalized Tonic-Clonic Seizures, or Lennox-Gastaut Syndrome - The recommended total daily dose of Topiramate as adjunctive therapy for patients with partial seizures, primary generalized tonic-clonic seizures, or seizures associated with Lennox-Gastaut Syndrome is approximately 5 to 9 mg/kg/day in two divided doses. Titration should begin at 25 mg (or less, based on a range of 1 to 3 mg/kg/day) nightly for the first week. The dosage should then be increased at 1 or 2 weeks intervals by increments of 1 to 3 mg/kg/day (administered in two divided doses), to achieve optimal clinical response.MigraineThe recommended total daily dose of Topiramate as treatment for prophylaxis of migraine headache is 100 mg/day administered in two divided doses.Pediatric Use: The safety of Topiramate has not been established in case of children under two.Side EffectsPatients may experience hypoglycemia while taking this medication. Topiramate may cause other side effects such as slow thinking or movements, difficulty concentrating, speech problems, specially difficulty thinking of specific words, memory problems, lack of coordination, trouble walking, confusion, nervousness, aggressive behavior depression, headache, extreme tiredness.PrecautionsThe major route of elimination of unchanged Topiramate and its metabolites is via the kidney. Dosage adjustment may be required in patients with reduced renal function. In hepatically impaired patients, Topiramate should be administered with caution as the clearance of Topiramate may be decreased.Use in Pregnancy & LactationPregnancy: Topiramate is pregnancy Category C. Topiramate should not be given to a pregnant woman.Nursing Mothers : It is not known whether this drug is excreted in human milk and so caution should be exercised when Topiramate is administered to a nursing woman.Drug InteractionDrugs like valproic acid, carbonic anhydrase (e.g. Acetazolamide), enzyme inducers (e.g. Carbamazepine), Phenytoin and Alcohol should be used with caution while taking Topiramate...

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Topmate 25

Topmate 25

Topmate 25..

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Topmate 50 mg

Topmate 50 mg

Topmate 50 mg..

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Tufnil 200 mg Tablet

Tufnil 200 mg Tablet

Tufnil 200 mg Tablet..

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Xetril 0.5 Tab

Xetril 0.5 Tab

Xetril 0.5 TabLiving with panic disorder is very common and this can be extremely debilitating to a person?s social, work and family relationship.Panic disorder is an anxiety disorder and is characterized by unexpected and repeated episodes of intense fear usually accompanied by a pounding heart, sweatiness, weakness, faintness, or dizziness. During these attacks, people with panic disorder may flush or feel chilled; hands may tingle or feel numb; and may experience nausea, chest pain, or smothering sensations. Panic attacks usually produce a sense of unreality, a fear of impending fate, or a fear of losing control.This disorder is a real illness that can be successfully treated with clonazepam i.e. Xetril. Clonazepam (Xetril) is a well established and preferred drug of choice for panic and seizure disorders in Bangladesh.Clonazepam (Xetril) is an anti-anxiety medication in the benzodiazepine family. Clonazepam (Xetril) acts by enhancing the effects of gamma-aminobutyric acid (GABA) in the brain. GABA is a neurotransmitter which inhibits many of the activities of the brain. It is believed that excessive activity in the brain may lead to anxiety or other psychiatric disorders. Clonazepam (Xetril) also is frequently used to prevent seizures.Because of strong anxiolytic properties and euphoric side-effects clonazepam is said to be among the class of 'highly potent' benzodiazepines. Although benzodiazepines are valuable in the treatment of anxiety disorders, they have some potential for misuse and may cause dependence or addiction. The sedative effects of clonazepam (Xetril) are relatively weak, when compared to its strong anxiolytic and anticonvulsant effects, as well as when compared to most other benzodiazepines.Offers effective relief of panic disorderEffectively treats major types of seizuresProven efficacy in panic attack reduction with recurrent chest painEstablished efficacy & safety over TCAs & MAOIs Xetril Prescribing Information..

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Xetril 2 Tablets

Xetril 2 Tablets

Living with panic disorder is very common and this can be extremely debilitating to a person?s social, work and family relationship. Panic disorder is an anxiety disorder and is characterized by unexpected and repeated episodes of intense fear usually accompanied by a pounding heart, sweatiness, weakness, faintness, or dizziness. During these attacks, people with panic disorder may flush or feel chilled; hands may tingle or feel numb; and may experience nausea, chest pain, or smothering sensations. Panic attacks usually produce a sense of unreality, a fear of impending fate, or a fear of losing control. This disorder is a real illness that can be successfully treated with clonazepam i.e. Xetril. Clonazepam (Xetril) is a well established and preferred drug of choice for panic and seizure disorders in Bangladesh.Clonazepam (Xetril) is an anti-anxiety medication in the benzodiazepine family. Clonazepam (Xetril) acts by enhancing the effects of gamma-aminobutyric acid (GABA) in the brain. GABA is a neurotransmitter which inhibits many of the activities of the brain. It is believed that excessive activity in the brain may lead to anxiety or other psychiatric disorders. Clonazepam (Xetril) also is frequently used to prevent seizures. Because of strong anxiolytic properties and euphoric side-effects clonazepam is said to be among the class of 'highly potent' benzodiazepines. Although benzodiazepines are valuable in the treatment of anxiety disorders, they have some potential for misuse and may cause dependence or addiction. The sedative effects of clonazepam (Xetril) are relatively weak, when compared to its strong anxiolytic and anticonvulsant effects, as well as when compared to most other benzodiazepines. Offers effective relief of panic disorderEffectively treats major types of seizuresProven efficacy in panic attack reduction with recurrent chest painEstablished efficacy & safety over TCAs & MAOIs Xetril Prescribing InformationLocated in: Central Nervous System..

Tk.2.00/=

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Zolmit 2.5mg Tablet

Zolmit 2.5mg Tablet

Zolmit 2.5..

Tk.25.00/=

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Zomitan 2.5 mg Tablet

Zomitan 2.5 mg Tablet

Zomitan 2.5TabDescriptionZolmitriptan is an antimigraine agent. It binds with high affinity to 5-HT1B/1D receptors. The therapeutic activity of Zolmitriptan for the treatment of migraine headache can most likely be attributed to the agonist effects at the 5-HT1B/1D receptors on intracranial blood vessels and sensory nerves of the trigeminal system which results in cranial vessel constriction and inhibition of pro-inflammatory neuropeptide release. Zolmitriptan is rapidly and well absorbed after oral administration.IndicationsZomitan 2.5 is indicated for the acute treatment of migraine with or without aura.Dosage & AdministrationThe recommended dose of Zolmitriptan to treat a migraine attack is 2.5 mg. If symptoms persist or return within 24 hours, a second dose may be taken not less than 2 hours after the first dose. The maximum dose of Zolmitriptan in 24 hours is 10 mg. Zolmitriptan is equally effective whenever the tablets are taken during a migraine attack; although it is advisable that Zolmitriptan tablets are taken as early as possible after the onset of migraine headache. Patients with hepatic impairment: Patients with moderate or severe hepatic impairment a maximum dose of 5 mg in 24 hours is recommended. Patients with renal impairment: No dosage adjustment required.Use in children: Safety and efficacy of Zolmitriptan in paediatric patients have not been established.Use in elderly patients: Safety and efficacy of Zolmitriptan in individuals aged over 65 years have not been systematically evaluated.Side EffectsZolmitriptan is well tolerated. Adverse reactions are typically mild/moderate, transient, not serious and resolve spontaneously without additional treatment. The most commonly reported adverse effects are nausea, dizziness, somnolence, asthenia and dry mouth. Disturbances of sensation have also been reported. Heaviness, tightness, pain or pressure may occur in the throat, neck, limbs and chest (with no evidence of ischaemic changes on ECG).PrecautionsZolmitriptan should only be used where a clear diagnosis of migraine has been established. Care should be taken to exclude other potentially serious neurological conditions. There are no data on the use of Zolmitriptan in hemiplegic or basilar migraine. Zolmitriptan should not be given to patients with symptomatic Wolff-Parkinson-White syndrome or arrhythmias associated with other cardiac accessory conduction pathways. In patients with risk factors for ischaemic heart disease, cardiovascular evaluation prior to commencement of treatment with this class of compounds, including Zolmitriptan, is recommended.Use in Pregnancy & LactationPregnancy: There are no studies in pregnant women, but there is no evidence of teratogenicity in animal studies. Zolmitriptan should be used in pregnancy only if the benefits to the mother justify potential risk to the foetus.Lactation: No data exists for passage of Zolmitriptan into human breast milk. Therefore, caution should be exercised when administrating Zolmitriptan to women who are breast-feeding.Drug InteractionThere is no evidence that concomitant use of migraine prophylactic medications has any effect on the efficacy or unwanted effects of Zolmitriptan. The pharmacokinetics and tolerability of Zolmitriptan are unaffected by acute symptomatic treatments such as paracetamol, metoclopramide and ergotamine. However, it is recommended that patients should leave at least 6 hours between taking an ergotamine preparation and starting Zolmitriptan and vice versa. Concomitant administration of other 5-HT1B/1D agonists within 12 hours of Zolmitriptan treatment should be avoided. Following administration of moclobemide, a specific MAO-A inhibitor, there was a small increase in AUC for Zolmitriptan and a 3-fold increase in AUC of the active metabolite. Therefore, a maximum intake of 7.5 mg Zolmitriptan in 24 hours is recommended in patients taking an MAO-A inhibitor.Over DoseThere is no experience with clinical overdose. Volunteers receiving single 50 mg oral doses of Zolmitriptan commonly experienced sedation. There is no specific antidote to Zolmitriptan. In case of severe intoxication, intensive care procedures are recommended...

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