Zox 500 mg tablet
Nitazoxanide is indicated in diarrhoea caused by Cryptosporidium parvum and Giardia lamblia, Amebiasis and helminth infections.
Nitazoxanide, a synthetic antiprotozoal agent. Nitazoxanide is well absorbed from GIT. It interferes with the Pyruvate Ferredoxin Oxidoreductase (PFOR) enzyme dependent electron transfer reaction which is essential to anaerobic glucose energy metabolism. This results in cell swelling, membrane damage resulting in dysfunction of the parasite.
Dosage & Administration
Age 1-3 years: 5 ml (100 mg) twice daily for 3 days
Age 4-11 years: 10 ml (200 mg) twice daily for 3 days
Age >12 years: 25 ml or 1 tablet (500 mg) twice daily for 3 days
The suspension or tablet should be taken with food.
Nitazoxanide is highly bound to plasma protein (>99.9%). Therefore, caution should be used when administering Nitazoxanide concurrently with other highly plasma-protein bound drugs.
Known hypersensitivity to Nitazoxanide or any other ingredient in the formulations
Nitazoxanide is generally well tolerated. However abdominal pain, diarrhoea vomiting and headache have been reported rarely
Pregnancy & Lactation
Pregnancy category B. This drug should be used during pregnancy only if clearly needed.
Nursing mother: It is not known whether Nitazoxanide is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Nitazoxanide is administrated to a nursing woman.
Nitazoxanide should be administrated with caution to patients with hepatic, renal and biliary disease.
Information on Nitazoxanide overdosage is not available. Single oral doses of up to 4000 mg Nitazoxanide have been administered to healthy adult volunteers without significant adverse effects.