- Stock: In Stock
- Brand: Sanofi Bangladesh Limited
- Product ID: Cephradine
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Abac 100mg/ml Injection
Generic Name: Cephradine BP 100mg/ml (equivalent to 500mg/5ml)
Manufacturer: Beximco Pharmaceuticals Ltd.
Drug Class: First-Generation Cephalosporin Antibiotic (Parenteral)
Dosage Form: Powder for Injection (Reconstituted to 100mg/ml solution)
Route: Intramuscular (IM) or Intravenous (IV)
Prescription Status: Prescription Only (Rx)
Mechanism of Action
Cephradine is a bactericidal first-generation cephalosporin. It inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), preventing peptidoglycan cross-linking and causing cell lysis. The parenteral form achieves higher and more reliable plasma concentrations than oral formulations, making it suitable for moderate-to-severe infections.
Spectrum of Activity
| Sensitivity | Organisms |
|---|---|
| Susceptible | Staphylococcus aureus (MSSA), Streptococcus spp., S. pneumoniae, E. coli, Klebsiella pneumoniae, Proteus mirabilis |
| Resistant | MRSA, Pseudomonas aeruginosa, Enterococcus spp., ESBL-producing organisms |
Indications
- Moderate-to-severe respiratory tract infections (pneumonia, pleuritis)
- Urinary tract infections including complicated UTIs and pyelonephritis (gram-positive organisms)
- Skin and soft tissue infections — cellulitis, surgical wound infections
- Bone and joint infections (osteomyelitis — initial parenteral therapy)
- Perioperative surgical prophylaxis
- Step-up therapy when oral cephradine absorption is inadequate
Dosage and Administration
| Indication | Adult Dose | Frequency |
|---|---|---|
| Moderate infections | 500 mg – 1g | Every 6 hours (IM or IV) |
| Severe/life-threatening | Up to 8g/day | Divided doses every 4–6 hours (IV) |
| Surgical prophylaxis | 1g | 30–60 min before procedure; repeat at 6 hours |
| Children | 50–100 mg/kg/day | Divided every 6 hours |
IM reconstitution: Add 4ml sterile water for injection to 500mg vial (yields ~5ml, 100mg/ml). IV: Dilute in 50–100ml NS or 5% dextrose and infuse over 30–60 minutes.
Important Notice for Diabetic Patients
- Diabetic foot infections (severe): Parenteral cephradine covers MSSA and Streptococcus but lacks MRSA and gram-negative (Pseudomonas, ESBL) coverage — combination therapy or carbapenem may be required for polymicrobial diabetic foot infections
- IV dextrose diluent: If diluted in 5% dextrose (D5W), account for the glucose load (~5g/100ml) in blood glucose monitoring for insulin-dependent diabetics
- Renal dose adjustment (diabetic nephropathy):
CrCl >20 ml/min: full dose every 6 hours
CrCl 5–20 ml/min: 50% dose reduction or extend interval to every 12 hours
CrCl <5 ml/min / dialysis: 250mg every 12–24 hours; supplement post-dialysis - Nephrotoxicity monitoring: Monitor serum creatinine and electrolytes at baseline and every 48–72 hours during prolonged parenteral therapy in patients with pre-existing diabetic nephropathy
- Stress hyperglycaemia: Systemic infection requiring parenteral antibiotics frequently causes significant hyperglycaemia — sliding-scale insulin or insulin infusion protocol may be required
Contraindications
- Hypersensitivity to cephradine or any cephalosporin
- History of anaphylaxis to penicillins (cross-reactivity possible)
- Severe renal failure without dose adjustment
Side Effects
| System | Side Effects |
|---|---|
| Local (injection site) | Pain, induration, phlebitis (IV), sterile abscess (IM) |
| Gastrointestinal | Nausea, diarrhoea, C. difficile-associated colitis |
| Hypersensitivity | Rash, urticaria, anaphylaxis (rare but potentially severe) |
| Renal | Transient rise in serum creatinine; rarely nephrotoxic at standard doses |
| Haematological | Eosinophilia, thrombocytopenia, positive Coombs test |
Storage
Unopened vial: Store below 25°C away from light. Reconstituted solution: Use immediately or within 2 hours at room temperature; may store at 2–8°C for up to 24 hours. Do not freeze. Discard unused portion.
Medical Disclaimer
The information provided here is for educational and informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Parenteral antibiotics must only be administered by qualified healthcare professionals in appropriate clinical settings. Always consult your doctor or pharmacist before starting any medication. DiabetesStore.com.bd does not endorse self-medication. Seek immediate medical attention in case of any adverse reaction.
