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- Product ID: Cephradine
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Abac 100mg/ml Injection (Cephradine)
Generic Name: Cephradine BP 100mg/ml
Manufacturer: Beximco Pharmaceuticals Ltd.
Drug Class: First-Generation Cephalosporin Antibiotic (Parenteral)
Dosage Form: Powder for Injection (Reconstituted to 100mg/ml solution)
Route: Intramuscular (IM) or Intravenous (IV)
Prescription Status: Prescription Only (Rx)
Mechanism of Action
Cephradine is a bactericidal first-generation cephalosporin. It inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), preventing peptidoglycan cross-linking and causing osmotic cell lysis. Parenteral administration achieves higher and more reliable plasma concentrations than oral formulations, making it suitable for moderate-to-severe infections.
Spectrum of Activity
| Sensitivity | Organisms |
|---|---|
| Susceptible | S. aureus (MSSA), Streptococcus spp., S. pneumoniae, E. coli, Klebsiella pneumoniae, Proteus mirabilis |
| Resistant | MRSA, Pseudomonas aeruginosa, Enterococcus spp., ESBL-producing organisms |
Indications
- Moderate-to-severe respiratory tract infections (pneumonia)
- Urinary tract infections — complicated UTI and pyelonephritis
- Skin and soft tissue infections (cellulitis, surgical wound infections)
- Bone and joint infections (osteomyelitis — initial IV therapy)
- Perioperative surgical prophylaxis
Dosage and Administration
| Indication | Adult Dose | Frequency |
|---|---|---|
| Moderate infections | 500mg – 1g | Every 6 hours (IM or IV) |
| Severe infections | Up to 8g/day | Divided every 4–6 hours (IV) |
| Surgical prophylaxis | 1g | 30–60 min pre-op; repeat at 6 hours |
| Children | 50–100 mg/kg/day | Divided every 6 hours |
IM: Add 4ml sterile water for injection to 500mg vial (100mg/ml). IV: Dilute in 50–100ml NS or D5W; infuse over 30–60 minutes.
Important Notice for Diabetic Patients
- Diabetic foot infections: Covers MSSA and Streptococcus but not MRSA or gram-negative Pseudomonas/ESBL organisms — combination therapy or broader agent may be needed for polymicrobial diabetic foot infections
- D5W diluent: If diluted in 5% dextrose, account for glucose load (~5g/100ml) in blood glucose monitoring for insulin-dependent patients
- Renal dose adjustment (diabetic nephropathy):
CrCl >20 ml/min: standard dose; CrCl 5–20 ml/min: halve dose or extend interval; CrCl <5 ml/min: 250mg every 12–24 hours; supplement post-haemodialysis - Renal monitoring: Check creatinine and electrolytes at baseline and every 48–72 hours during prolonged parenteral therapy in patients with diabetic nephropathy
- Stress hyperglycaemia: Systemic infections frequently cause significant hyperglycaemia — insulin dose adjustment or infusion protocol may be required during inpatient treatment
Contraindications
- Hypersensitivity to cephradine or any cephalosporin
- Anaphylactic reaction to penicillins (cross-reactivity possible)
- Severe renal failure without dose adjustment
Side Effects
| System | Side Effects |
|---|---|
| Local | Pain, induration at IM site; phlebitis with IV |
| Gastrointestinal | Nausea, diarrhoea, C. difficile colitis (rare) |
| Hypersensitivity | Rash, urticaria, anaphylaxis (rare) |
| Haematological/Renal | Eosinophilia, thrombocytopenia, transient creatinine rise |
Storage
Unopened: Store below 25°C away from light. Reconstituted: Use within 2 hours at room temperature or up to 24 hours refrigerated (2–8°C). Do not freeze. Discard unused portion.
Medical Disclaimer
The information provided here is for educational and informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Parenteral antibiotics must only be administered by qualified healthcare professionals in appropriate clinical settings. DiabetesStore.com.bd does not endorse self-medication. Seek immediate medical attention in case of any adverse reaction.
