- Stock: Out Of Stock
- Brand: ACI Pharmaceuticals
- Product ID: Cefaclor Monohydrate
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Abaclor 500mg Capsule
Generic Name: Cefaclor Monohydrate 500mg
Manufacturer: Beximco Pharmaceuticals Ltd.
Drug Class: Second-Generation Cephalosporin Antibiotic
Dosage Form: Hard Gelatin Capsule
Prescription Status: Prescription Only (Rx)
Mechanism of Action
Cefaclor is a bactericidal second-generation cephalosporin. It inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), preventing peptidoglycan cross-linking. The 500mg strength achieves higher tissue concentrations suited for moderate-to-severe infections, particularly those caused by beta-lactamase-producing respiratory pathogens and gram-negative organisms resistant to first-generation cephalosporins.
Spectrum of Activity
| Sensitivity | Organisms |
|---|---|
| Gram-positive | S. aureus (MSSA), S. pyogenes, S. pneumoniae, S. agalactiae |
| Gram-negative | H. influenzae, E. coli, Klebsiella pneumoniae, Proteus mirabilis, Moraxella catarrhalis |
| Resistant | MRSA, Pseudomonas aeruginosa, Enterococcus spp., ESBL-producing organisms |
Indications
- Moderate-to-severe respiratory tract infections (community-acquired pneumonia, AECB, sinusitis)
- Otitis media caused by beta-lactamase-producing H. influenzae
- Urinary tract infections — cystitis and uncomplicated pyelonephritis
- Skin and soft tissue infections (cellulitis, wound infections)
Dosage and Administration
| Patient | Dose | Frequency | Duration |
|---|---|---|---|
| Adults (moderate infections) | 250–500 mg | Every 8 hours | 7–10 days |
| Adults (severe RTI / pneumonia) | 500 mg | Every 8 hours | 10–14 days |
| Max daily dose | 4g/day | — | As directed |
May be taken with or without food. Complete the full prescribed course to prevent resistance. Max adult dose: 4g/day.
Important Notice for Diabetic Patients
- Diabetic foot/skin infections: Covers MSSA and Streptococcus — NOT MRSA or gram-negative polymicrobial pathogens; culture essential for moderate-to-severe diabetic foot infections
- Diabetic respiratory infections: Good ambulatory choice for community-acquired pneumonia where H. influenzae is likely; review if no improvement at 48–72 hours
- Renal dose adjustment (diabetic nephropathy): Reduce dose by 50% or extend interval when CrCl <30 ml/min — verify current eGFR before prescribing
- False-positive urine glucose: Use glucose oxidase dipstick only — copper reduction tests give false-positive results with cefaclor
- Serum sickness-like reaction: Higher incidence than other oral cephalosporins — discontinue if fever, rash, arthralgia occur together
- Infection-related hyperglycaemia: Intensify blood glucose monitoring throughout treatment
Contraindications
- Hypersensitivity to cefaclor or any cephalosporin
- History of immediate hypersensitivity to penicillins
- Severe renal failure without dose adjustment
Side Effects
| System | Side Effects |
|---|---|
| Gastrointestinal | Nausea, diarrhoea, abdominal discomfort, C. difficile colitis (rare) |
| Hypersensitivity | Serum sickness-like reaction (fever, rash, arthralgia), urticaria, anaphylaxis (rare) |
| Haematological/Hepatic | Eosinophilia, transient neutropenia, elevated liver enzymes |
Drug Interactions
- Probenecid: Increases cefaclor plasma levels
- Warfarin: Possible potentiation — monitor INR
- Antacids: Reduce absorption; separate by 2 hours
- Metformin: No direct interaction; review if renal function declines
Storage
Store below 25°C in a cool, dry place away from moisture and light. Keep out of reach of children.
Medical Disclaimer
The information provided here is for educational and informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your doctor or pharmacist before starting, stopping, or altering any medication. Antibiotic therapy should be guided by culture and sensitivity results where possible. DiabetesStore.com.bd does not endorse self-medication. Seek immediate medical attention in case of any adverse reaction.
