- Stock: In Stock
- Brand: Beximco Pharmaceutical
- Product ID: Atorvastatin calcium
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Atova 20 mg Tablet — Atorvastatin | Beximco Pharmaceuticals
| Generic Name | Atorvastatin Calcium |
| Strength | 20 mg |
| Dosage Form | Film-Coated Tablet |
| Manufacturer | Beximco Pharmaceuticals Ltd. |
| Therapeutic Class | HMG-CoA Reductase Inhibitor (Statin) |
| Pack Size | 30 Tablets per Box |
| Availability | In Stock — Available Online |
Overview
Atova 20 mg Tablet contains Atorvastatin Calcium 20 mg, manufactured by Beximco Pharmaceuticals Ltd. At 20 mg, Atorvastatin is classified as a moderate-intensity statin that reduces LDL cholesterol by approximately 43%. It is prescribed for patients with T2DM who have moderate cardiovascular risk factors, patients with primary hypercholesterolaemia not adequately controlled on 10 mg, and as per ADA guidelines for diabetic patients aged 40–75 with at least one additional cardiovascular risk factor. Atova 20 mg strikes the balance between efficacy and tolerability for most T2DM patients in Bangladesh requiring statin therapy.
Indications
- Type 2 Diabetes with cardiovascular risk factors — ADA guideline: moderate-intensity statin (10–20 mg) for T2DM aged 40–75 with ≥1 CV risk factor
- Primary Hypercholesterolaemia — inadequate response to 10 mg
- Mixed Dyslipidaemia — elevated LDL + triglycerides + low HDL
- Hypertension + Dyslipidaemia — dual cardiovascular risk reduction
- Step-up from Atova 10 mg — when LDL target not achieved
Key Benefits
- ~43% LDL reduction — stronger than 10 mg (~37%) but with similar tolerability
- Proven cardiovascular event reduction (heart attack, stroke, revascularisation)
- Recommended for nearly all T2DM patients with CV risk by ADA/ACC guidelines
- Once daily, any time — flexible dosing schedule
- Manufactured under WHO-GMP standards by Beximco Pharmaceuticals
Pharmacology
Atorvastatin inhibits HMG-CoA reductase, reducing hepatic cholesterol synthesis and upregulating LDL receptors on liver cells for increased LDL clearance. At 20 mg, the degree of HMG-CoA reductase inhibition is proportionally greater than at 10 mg. Beyond LDL reduction, Atorvastatin at this dose significantly reduces CRP (inflammation marker), stabilises atherosclerotic plaques, and improves endothelial function — benefits that are particularly important in T2DM patients who have chronic low-grade vascular inflammation.
Dosage & Administration
| Indication | Dose | Notes |
|---|---|---|
| T2DM aged 40–75 with CV risk (ADA) | 10–20 mg once daily | Moderate-intensity statin |
| Primary hypercholesterolaemia | 10–20 mg once daily | Target LDL <100 mg/dL (or <70 for high risk) |
| High-risk patients (post-MI, DM+CVD) | 40–80 mg once daily | Consider Atova 40 mg |
Take once daily at any time of day, with or without food.
Contraindications
- Active liver disease or persistently elevated liver transaminases
- Pregnancy (Category X — absolute contraindication)
- Breastfeeding
- Hypersensitivity to Atorvastatin or any excipient
Warnings
- Myopathy/Rhabdomyolysis: Report unexplained muscle pain or weakness immediately
- Liver function: Monitor if symptoms of hepatic injury occur
- Drug interactions: CYP3A4 inhibitors markedly increase Atorvastatin levels at this dose
- Pregnancy: Must not be used — teratogenic; use effective contraception
Drug Interactions
| Drug | Interaction |
|---|---|
| Clarithromycin / Erythromycin | CYP3A4 inhibition — significantly raises Atorvastatin levels; consider temporary withholding |
| Itraconazole / Ketoconazole | Strong CYP3A4 inhibitors — avoid combination or reduce statin dose |
| Cyclosporine | Contraindicated — markedly increases statin levels |
| Amlodipine (Amdocal) | Modestly increases Atorvastatin — limit to 20 mg/day with amlodipine |
| Rifampicin | Reduces Atorvastatin efficacy — monitor lipid response |
Side Effects
Common: Nasopharyngitis, arthralgia, diarrhoea, myalgia, nausea, headache, insomnia.
Uncommon: Elevated liver enzymes, hyperglycaemia, back pain.
Rare: Myopathy, rhabdomyolysis, hepatitis.
Storage
- Below 30°C, protected from moisture and sunlight. Keep in original blister. Out of reach of children.
Frequently Asked Questions
Q1: What is Atova 20 mg used for?
Atova 20 mg lowers LDL cholesterol by ~43% and reduces cardiovascular risk. It is prescribed for T2DM patients aged 40–75 with cardiovascular risk factors, and for patients with hypercholesterolaemia not adequately controlled on 10 mg.
Q2: How does Atova 20 mg differ from Atova 10 mg?
Atova 20 mg provides a stronger LDL reduction (~43% vs ~37–39% with 10 mg). It is used when the 10 mg dose does not reach target LDL levels, or when guidelines recommend a moderate-to-high intensity statin.
Q3: Can I take Atova 20 mg with Metformin (Compimet)?
Yes — Metformin and Atorvastatin have no clinically significant pharmacokinetic interaction. They are frequently co-prescribed in T2DM management. Metformin controls blood glucose; Atorvastatin controls cholesterol and cardiovascular risk.
Q4: Does Atova 20 mg affect blood sugar?
Statins may slightly raise fasting glucose and HbA1c in some patients. The effect at 20 mg is small and is far outweighed by the cardiovascular protection provided. Your physician will continue to monitor your HbA1c.
Q5: Is Atova 20 mg prescription-only?
Yes — Rx medicine. Upload your prescription when ordering from DiabetesStore.com.bd.
Medical Disclaimer: Educational purposes only. Always consult a registered physician or pharmacist before starting, changing, or stopping any medication.
