- Stock: In Stock
- Brand: Beximco Pharmaceutical
- Product ID: Fexofenadine Hydrochloride
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Axodin 60mg Tablet — Fexofenadine Hydrochloride 60mg | Beximco Pharmaceuticals
| Generic Name | Fexofenadine Hydrochloride 60 mg |
| Dosage Form | Film-coated Tablet |
| Manufacturer | Beximco Pharmaceuticals Ltd. |
| Therapeutic Class | Non-Sedating (Second-Generation) Antihistamine (H1 Receptor Antagonist) |
| Availability | In Stock — Available Online |
Overview
Axodin 60mg contains Fexofenadine Hydrochloride 60 mg, a selective peripheral H1 receptor antagonist and the active metabolite of terfenadine. Fexofenadine is classified as a non-sedating (second-generation) antihistamine — it does not cross the blood-brain barrier at therapeutic doses, meaning it causes minimal or no drowsiness compared to first-generation antihistamines (chlorphenamine, promethazine). The 60 mg twice-daily dosing is typically used for seasonal allergic rhinitis. Fexofenadine does not cause the QT prolongation associated with its predecessor terfenadine, making it safe for routine clinical use.
Fexofenadine Dose Comparison
| Strength | Dose | Frequency | Primary Use |
|---|---|---|---|
| Axodin 60mg (this) | 60 mg | Twice daily | Seasonal allergic rhinitis |
| Axodin 120mg | 120 mg | Once daily | Seasonal allergic rhinitis (OD convenience) |
| Axodin 180mg | 180 mg | Once daily | Chronic idiopathic urticaria |
Indications
- Seasonal Allergic Rhinitis (Hay Fever) — sneezing, nasal discharge, itchy/watery eyes, nasal congestion due to pollen, dust mites, pet dander
- Perennial Allergic Rhinitis — year-round allergy symptoms
- Allergic Skin Reactions — urticaria (hives), pruritus, angioedema (adjunct)
Pharmacology
Fexofenadine competitively blocks peripheral histamine H1 receptors, preventing histamine-mediated effects: vasodilation, increased vascular permeability, smooth muscle contraction, mucus hypersecretion, pruritus, and sneezing. It has high selectivity for peripheral H1 receptors and negligible CNS penetration, accounting for the absence of sedation. Onset of action: 1 hour; peak effect: 2–3 hours; duration: 12 hours (60 mg) to 24 hours (120/180 mg). Primarily excreted unchanged via faeces; minimal hepatic metabolism — safe in patients on multiple medications.
Dosage & Administration
| Indication | Dose | Frequency |
|---|---|---|
| Seasonal Allergic Rhinitis (adults & children ≥12 yr) | 60 mg | Twice daily |
| Children 6–11 years | 30 mg (half tablet) | Twice daily |
Take with water. Can be taken with or without food. Avoid taking with fruit juice (grapefruit, orange, apple juice) — significantly reduces fexofenadine absorption by up to 36%. Take with water only.
Special Note for Diabetic Patients
Fexofenadine has no known effect on blood glucose, insulin sensitivity, or glycaemic control. Axodin 60mg is safe for patients with diabetes requiring antihistamine therapy for allergic rhinitis or urticaria. Unlike older antihistamines (promethazine, chlorphenamine), it causes no sedation — patients can continue daily activities including driving.
Drug Interactions
| Drug/Food | Interaction |
|---|---|
| Fruit juices (grapefruit, orange, apple) | Reduce fexofenadine absorption by ~36% — take with water only |
| Antacids (aluminium/magnesium) | May reduce fexofenadine absorption — separate by 2 hours |
| Erythromycin / Ketoconazole | Increase fexofenadine plasma levels (no clinical significance at therapeutic doses) |
Side Effects
- Common: Headache, dizziness, nausea (all rare and mild)
- Rare: Insomnia, fatigue
- Very rare: Hypersensitivity reactions — rash, urticaria, anaphylaxis
- CNS: Minimal — fexofenadine is non-sedating at recommended doses
Contraindications
- Hypersensitivity to fexofenadine or any tablet excipient
- Use with caution in severe renal impairment (GFR <20 mL/min) — reduce dose frequency
Storage
- Store below 30°C in a dry place, protected from light. Keep out of reach of children.
FAQ
Q1: Will Axodin 60mg make me drowsy?
No. Fexofenadine is a non-sedating (second-generation) antihistamine that does not significantly cross the blood-brain barrier. Unlike older antihistamines (piriton, avil), Axodin 60mg will not cause drowsiness, and you can safely drive and operate machinery while taking it.
Q2: Why must I take Axodin 60mg twice daily when I see Axodin 120mg is once daily?
The 60mg dose provides approximately 12 hours of antihistamine coverage, requiring twice-daily dosing. The 120mg formulation is a higher dose designed to provide 24-hour (once-daily) coverage. Both are effective — the 60mg BD gives flexibility to adjust timing around symptoms, while the 120mg OD is more convenient for compliance.
Q3: Can I take Axodin with my diabetes or blood pressure medicines?
Fexofenadine has very few drug interactions. It does not interact with metformin, glipizide, insulin, ACE inhibitors, beta-blockers, or most commonly used medicines. Avoid taking it with antacids (wait 2 hours) and avoid washing it down with fruit juice. Inform your physician of all medications to be certain.
Q4: Is prescription required?
Fexofenadine (Axodin) is available OTC in many countries but is classified as prescription-only in Bangladesh. Upload a prescription from your physician when ordering from DiabetesStore.com.bd.
Medical Disclaimer: Educational information only. Use under physician guidance, especially if you have other medical conditions.
