Cefotil 750mg IM/IV Injection

Overview

Cefotil 750 mg Injection contains Cefuroxime Axetil, manufactured by Square Pharmaceuticals PLC. It is a parenteral second-generation cephalosporin used for the treatment of moderate to severe bacterial infections including pneumonia, meningitis (caused by susceptible organisms), urinary tract infections, skin and soft tissue infections, and septicaemia in hospital settings.

Dosage and Administration

Adults: 750 mg–1.5 g three times daily by IM or IV injection/infusion, depending on severity. Administer IV doses over 3–5 minutes or by infusion over 30 minutes. Duration as per physician direction.

Interaction

Probenecid increases cefuroxime serum levels. May potentiate anticoagulant effects. Aminoglycosides should be given separately.

Contraindications

Contraindicated in patients with hypersensitivity to cephalosporins or penicillins.

Side Effects

Injection site pain, phlebitis, nausea, hypersensitivity reactions, and transient increases in liver enzymes.

Pregnancy and Lactation

Category B in pregnancy; use only when clearly indicated. May be excreted in breast milk.

Precautions and Warnings

Use with caution in patients with renal impairment (dose adjustment required). Monitor for signs of superinfection with prolonged use.

Storage Conditions

Store dry powder below 25°C, away from light. Reconstituted solution should be used promptly.

Frequently Asked Questions

Can Cefotil injection be given intramuscularly?
Yes — Cefotil 750 mg may be given by deep IM injection, though IV administration is preferred for serious infections.

Is a dose adjustment needed for patients with kidney disease?
Yes — in significant renal impairment, dosing intervals should be extended as directed by the prescribing physician.

This content is for informational purposes only and does not substitute professional medical advice. Please consult a registered physician before taking any medication.