Insulet GN 100 IU/ml 3 ml vial Injection

Insulet GN – Insulin Glargine 100 IU/ml 3ml Vial by Healthcare Pharmaceuticals

What is Insulet GN?

Insulet GN is the insulin glargine formulation in Healthcare Pharmaceuticals Ltd.'s Insulet insulin range. Containing insulin glargine 100 IU/ml in a 3 ml vial, it provides once-daily long-acting basal insulin coverage for approximately 24 hours with no pronounced peak. As a locally manufactured glargine biosimilar, Insulet GN offers the clinical profile of insulin glargine — stable peakless basal glucose control, low day-to-day variability, reduced nocturnal hypoglycaemia risk compared to NPH — at a significantly more accessible price than imported originator brands. Suitable for Type 1 and Type 2 diabetes in adults and children 6 years and older.

Generic Name and Composition

Each ml: 100 IU insulin glargine (rDNA). Glargine's A21 glycine substitution and two additional B30 arginine residues shift the isoelectric point to physiological pH. SC injection causes microprecipitation into slowly dissolving microcrystals — producing a flat, peakless ~24-hour insulin release profile.

Indications

• Type 2 diabetes — once-daily basal insulin with or without OADs
• Type 1 diabetes — basal component in basal-bolus regimen
• Adults, adolescents, and children aged 6 years and above
• Patients preferring a locally manufactured glargine at reduced cost

How It Works — Mechanism of Action

Insulet GN is formulated at pH 4 (clear solution). On SC injection, physiological pH neutralisation causes microprecipitation into stable glargine microcrystals. Slow crystal dissolution releases insulin monomers into capillaries at a steady, peakless rate over ~24 hours — mimicking physiological basal insulin secretion and providing stable fasting and overnight glucose control.

Dosage and Administration

Type 2 (insulin-naive): 10 IU once daily (bedtime preferred); titrate by 2 IU every 3 days. Type 1: Individualised basal dose. Inject SC with U-100 insulin syringe (abdomen, thigh, or upper arm). Do not administer IV or IM. Do not mix with other insulins.

Side Effects

Very common: Hypoglycaemia. Common: Injection site reactions, lipohypertrophy, weight gain, oedema. Uncommon: Lipoatrophy, visual changes at initiation. Rare: Generalised hypersensitivity, anaphylaxis.

Drug Interactions

Enhance hypoglycaemia: OADs, GLP-1 agonists, SGLT-2 inhibitors, ACE inhibitors, MAO inhibitors, salicylates, alcohol. Reduce effect: Corticosteroids, thyroid hormones, sympathomimetics, thiazides, oral contraceptives. Mask symptoms: Beta-blockers, clonidine.

Contraindications

• Hypersensitivity to insulin glargine or any excipient
• Active hypoglycaemia; IV/IM administration; mixing with other insulins

Pregnancy and Lactation

Pregnancy: Limited data; human NPH preferred under specialist care. Lactation: No clinically significant infant exposure expected.

Precautions and Warnings

• Never mix Insulet GN with other insulins.
• Insulet GN is a clear solution — discard if cloudy or particulate.
• Rotate injection sites to prevent lipohypertrophy.
• Do not freeze. Protect from direct heat and sunlight.

Overdose

Hypoglycaemia. Mild: oral glucose. Severe: IV dextrose or IM glucagon 1 mg. Monitor 2–4 hourly given ~24 hr action duration.

Storage Instructions

• Unopened: 2–8 degrees C. Do not freeze.
• In-use vial: Below 25 degrees C. Protect from light.
• Discard 28 days after first use.

Frequently Asked Questions

Q1: What does "GN" stand for in Insulet GN?
GN stands for Glargine — reflecting that Insulet GN contains insulin glargine, the long-acting basal insulin analogue. The Insulet brand (Healthcare Pharmaceuticals) uses letter codes to distinguish its insulin types: GN = glargine, ASP = aspart, N = isophane/NPH.

Q2: How does Insulet GN compare to Glarine or Lantus?
All three contain insulin glargine 100 IU/ml. Lantus (Sanofi, France) is the originator. Glarine (Incepta) and Insulet GN (Healthcare Pharmaceuticals) are locally manufactured biosimilars with equivalent clinical profiles at lower cost. Choice depends on availability and physician preference.

Q3: Can Insulet GN be used with Insulet ASP in a basal-bolus regimen?
Yes — Insulet GN as basal (once daily) combined with Insulet ASP (rapid-acting aspart before meals) forms a complete basal-bolus regimen using products from the same local manufacturer. Doses should be individualised under diabetologist guidance.

Q4: Why should Insulet GN never be mixed with Insulet 30/70?
Insulet GN (glargine) is formulated at pH 4. Mixing with any other insulin, including Insulet 30/70 (pH ~7), causes immediate precipitation and unpredictable pharmacokinetics. Always inject them separately at different sites or different times.

Medical Disclaimer: For educational purposes only. Insulet GN is Rx-only. Consult your diabetologist before starting or changing insulin therapy. DiabetesStore.com.bd is a licensed online pharmacy in Bangladesh.