MarinCal-DX Tablet 600mg/400 IU - Calcium Carbonate + Vitamin D | Incepta

What is MarinCal-DX Tablet?

MarinCal-DX Tablet is a high-strength calcium and vitamin D combination supplement manufactured by Incepta Pharmaceuticals Ltd. It combines Coral-source Calcium Carbonate with Vitamin D to support bone health and treat calcium deficiency-related conditions.

Generic Name and Composition

Each tablet contains Calcium Carbonate USP (Coral source) 1500 mg, equivalent to elemental Calcium 600 mg, plus Vitamin D USP 400 IU. Coral calcium also naturally contains small amounts of magnesium and trace minerals, and its structure closely resembles human bone calcium carbonate, supporting good absorption.

Indications

• Treatment and prevention of osteoporosis
• Osteomalacia and rickets
• Tetany and hypoparathyroidism
• Inadequate calcium intake in childhood diet (as advised by physician)
• Increased calcium requirement during pregnancy and lactation
• Use as a phosphate binder in chronic renal failure (under medical supervision)
• Supplementation in elderly patients at risk of calcium deficiency

How It Works - Mechanism of Action

Calcium Carbonate provides elemental calcium required for bone mineralization, neuromuscular function, and various enzymatic processes. Vitamin D enhances intestinal absorption of calcium and phosphate after conversion to its active form (calcitriol) in the liver and kidneys, working synergistically with calcium to support bone formation, density, and overall skeletal health.

Dosage and Administration

• Usual adult dose: 1 tablet once daily, or as directed by physician
• Best taken with or after meals to enhance calcium absorption and reduce gastrointestinal discomfort
• Swallow tablet with a full glass of water
• For phosphate-binding use in renal failure, dosing should be strictly individualized and supervised by a nephrologist
• Duration of therapy should be individualized based on calcium/vitamin D status and clinical condition

Side Effects

Common: Mild gastrointestinal discomfort, constipation, bloating

Uncommon: Nausea, flatulence

Rare: Hypercalcemia, hypercalciuria, and milk-alkali syndrome with excessive or prolonged high-dose use

Drug Interactions

Tetracyclines and Fluoroquinolone Antibiotics: Calcium reduces absorption of these antibiotics - separate dosing by at least 2-3 hours

Levothyroxine: Calcium can reduce absorption of levothyroxine - separate dosing by at least 4 hours

Thiazide Diuretics: May increase risk of hypercalcemia when combined with calcium/vitamin D supplementation

Digoxin: Hypercalcemia may increase risk of digoxin toxicity - use with caution

Iron Supplements: Calcium may reduce iron absorption - separate dosing if both are required

Contraindications

• Known hypersensitivity to calcium carbonate, vitamin D, or any excipient
• Hypercalcemia or hypercalciuria
• Conditions associated with vitamin D toxicity (hypervitaminosis D)
• Severe renal impairment with risk of soft tissue calcification, except when used specifically as a phosphate binder under nephrologist supervision

Pregnancy and Lactation

Calcium and Vitamin D supplementation at recommended doses is generally considered safe and often recommended during pregnancy and lactation to meet increased physiological demand. Please follow your physician's specific dosing recommendations during this period.

Precautions and Warnings

• Use with caution in patients with a history of kidney stones or renal impairment, except when prescribed specifically for renal phosphate binding
• Avoid excessive intake beyond recommended doses to prevent hypercalcemia
• Patients with sarcoidosis or other granulomatous diseases should use vitamin D supplements cautiously due to increased sensitivity
• Periodic monitoring of serum calcium may be advised with long-term use, especially in at-risk patients
• Separate timing from other medications known to interact with calcium (see Drug Interactions)

Overdose

Overdose may lead to hypercalcemia with symptoms such as nausea, vomiting, constipation, confusion, and in severe cases, renal impairment or cardiac arrhythmias. Discontinue use and seek immediate medical attention. Management is generally supportive, including hydration and monitoring of serum calcium under medical care.

Storage Instructions

• Store below 30°C in a cool, dry place
• Protect from light and moisture
• Keep in original packaging
• Keep out of reach of children

Frequently Asked Questions

Q1: What is MarinCal-DX Tablet used for?
A1: It is used to treat and prevent osteoporosis, osteomalacia, rickets, tetany, and other calcium deficiency-related conditions.

Q2: When is the best time to take MarinCal-DX?
A2: It is best taken with or after meals to improve calcium absorption and minimize gastrointestinal upset.

Q3: Can MarinCal-DX be used in kidney disease?
A3: MarinCal-DX may be used as a phosphate binder in chronic renal failure, but only under close supervision by a nephrologist due to the risk of calcium accumulation - never self-administer for this purpose.

Q4: How does MarinCal-DX differ from MarinCal-D?
A4: MarinCal-DX provides a higher strength of elemental calcium (600 mg) and Vitamin D (400 IU) compared to MarinCal-D (500 mg elemental calcium + 200 IU Vitamin D). MarinCal-DX is often used for more significant calcium deficiency or higher-demand conditions, while MarinCal-D suits routine supplementation. Your physician will determine which strength is appropriate for your needs.

Medical Disclaimer

This product should be used under medical/physician guidance, particularly for therapeutic indications. The information provided here is for educational purposes and does not replace professional medical advice. DiabetesStore.com.bd is a licensed online pharmacy in Bangladesh. Please consult your doctor before starting, stopping, or changing any medication or supplement.