- Stock: In Stock
- Brand: Sanofi Bangladesh Limited
- Product ID: Multivitamin & Multimineral [A-Z silver preparation]
Available Options
100% Secure Payment
bKash | Nagad | Cards via SSLCommerz | COD
Monthly Medicines Available | Free Delivery on Eligible Orders
A Vit-2 Soft Capsule — Vitamin A 200,000 IU
Generic Name: Retinol (Vitamin A) 200,000 IU (60mg)
Manufacturer: Beximco Pharmaceuticals Ltd.
Drug Class: Fat-Soluble Vitamin — Retinoid (High-Dose Therapeutic)
Dosage Form: Soft Gelatin Capsule
Prescription Status: Prescription Only — Medical Supervision Required
About A Vit-2 — 200,000 IU Therapeutic Dose
A Vit-2 provides 200,000 IU (approximately 60mg retinol equivalent) — the standard WHO high-dose therapeutic capsule used in mass Vitamin A supplementation programmes for children and in severe clinical deficiency. It is double the strength of A Vit-1 (100,000 IU) and requires strict adherence to dosing schedules to avoid toxicity.
Key Physiological Roles of Vitamin A
| System | Function |
|---|---|
| Vision | Synthesis of rhodopsin for night vision and dark adaptation |
| Immune defence | Maintains mucosal epithelial barriers; T-cell and antibody-mediated immunity |
| Cellular differentiation | Retinoic acid regulates gene expression via RAR/RXR nuclear receptors |
| Skin & epithelia | Maintains integrity of skin, GI tract, respiratory and urinary mucosa |
| Pancreatic function | Retinoic acid modulates pancreatic beta-cell differentiation and insulin secretion |
Indications for 200,000 IU Dose
- Severe Vitamin A deficiency with ocular complications: Active xerophthalmia, corneal ulceration, keratomalacia
- WHO Child Supplementation Programme: Children aged 12 months to 5 years in endemic areas — 200,000 IU every 4–6 months
- Measles: 200,000 IU on Day 1 and Day 2 to reduce morbidity and mortality
- Severe fat malabsorption: Biliary atresia, short bowel syndrome, cystic fibrosis, pancreatic insufficiency
- Post-bariatric surgery: Vitamin A malabsorption following gastric bypass
Dosage and Administration
| Indication / Group | Dose | Schedule |
|---|---|---|
| Children 12 months – 5 years (prophylaxis) | 200,000 IU | Every 4–6 months (WHO) |
| Severe deficiency / xerophthalmia (children >1 year) | 200,000 IU | Day 1, Day 2, Day 14 |
| Measles (children >12 months) | 200,000 IU | Day 1 and Day 2 of diagnosis |
| Adults — severe deficiency | 200,000 IU | Single dose; repeat per physician instruction only |
| Infants 6–12 months | 100,000 IU (half capsule) | Single dose |
Always take with a fatty meal to maximise absorption. Do not exceed prescribed frequency. Do not repeat within 1 month unless directed by physician.
Toxicity Warning — Hypervitaminosis A
Vitamin A is stored in the liver. Repeated high-dose administration causes accumulation and toxicity:
- Acute (overdose): Headache, nausea, vomiting, dizziness, bulging fontanelle in infants, raised intracranial pressure
- Chronic: Liver damage, cirrhosis, bone pain and fractures, hair loss, peeling skin, pseudotumour cerebri, fatigue
- Teratogenicity: STRICTLY CONTRAINDICATED in pregnancy at high doses — causes severe fetal malformations (craniofacial, cardiac, CNS, limb defects). Do not administer to women who may be pregnant
- Safe upper limit: Regular supplementation should not exceed 10,000 IU/day in adults; 200,000 IU therapeutic doses are for short-course clinical use only, at prescribed intervals
Vitamin A and Diabetic Patients
- Diabetic retinopathy vs. Vitamin A deficiency: Both conditions impair vision but by different mechanisms — Vitamin A supplementation does NOT treat diabetic retinopathy and should not be used as a substitute for ophthalmological management
- Night blindness evaluation: In diabetic patients complaining of deteriorating night vision, both diabetic retinopathy and Vitamin A deficiency should be assessed — serum retinol level is the key test
- NAFLD/hepatic risk: Non-alcoholic fatty liver disease (highly prevalent in Type 2 diabetes) increases susceptibility to Vitamin A hepatotoxicity — 200,000 IU doses require liver function test baseline in all diabetic patients
- Bariatric surgery and diabetes: Post-bariatric diabetic patients are at significant risk of fat-soluble vitamin deficiency — Vitamin A monitoring and supplementation protocols should be part of post-operative diabetic care
- Renal impairment: Vitamin A accumulates in chronic kidney disease (common in diabetics) — avoid repeated high-dose therapy without nephrology review in patients with CKD stage 3+
- Zinc co-deficiency: Zinc deficiency (prevalent in diabetes) impairs retinol-binding protein synthesis, causing functional Vitamin A deficiency even with adequate stores — always assess zinc status concurrently
Contraindications
- Pregnancy at any stage — teratogenic at doses >10,000 IU/day
- Women of childbearing potential without effective contraception
- Hypervitaminosis A
- Severe hepatic failure or liver cirrhosis
- Concurrent systemic retinoid therapy (isotretinoin, acitretin)
- Hypercalcaemia (concurrent high-dose Vitamin D)
Drug Interactions
- Retinoids (isotretinoin, acitretin): Additive Vitamin A toxicity — do not combine
- Orlistat: Reduces fat-soluble vitamin absorption — separate doses by 2 hours
- Warfarin: High-dose Vitamin A may enhance anticoagulation — monitor INR
- Colestyramine / mineral oil: Reduce Vitamin A absorption
- Neomycin: May reduce Vitamin A absorption from gut
Storage
Store below 25°C in a cool, dry place protected from light and heat. Soft gelatin capsules are susceptible to heat and humidity — do not store near stoves or in direct sunlight. Keep out of reach of children.
Medical Disclaimer
The information provided here is for educational and informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. A Vit-2 200,000 IU is a high-dose therapeutic Vitamin A preparation that must only be used under medical supervision for diagnosed clinical deficiency. Self-supplementation with this dose carries serious risks of toxicity. This product is absolutely contraindicated in pregnancy. Always consult your doctor or pharmacist before use. DiabetesStore.com.bd does not endorse self-medication. Seek immediate medical attention in case of any signs of toxicity.
