- Stock: In Stock
- Brand: Square Pharmaceuticals
- Product ID: Cotrimoxazole
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| Generic Name | Sulphamethoxazole + Trimethoprim |
| Strength | 800 mg + 160 mg |
| Dosage Form | Tablet |
| Manufacturer | Square Pharmaceuticals PLC |
| Therapeutic Class | Sulfonamide Antibiotic Combination |
| Pack Size | 100 tablets per bottle (DS) |
Overview
Cotrim DS contains Sulphamethoxazole + Trimethoprim (Co-trimoxazole) in a 800 mg + 160 mg tablet, manufactured by Square Pharmaceuticals PLC. It is used for the treatment of urinary tract infections, respiratory tract infections (including Pneumocystis jirovecii pneumonia), typhoid fever, shigellosis, and other infections caused by susceptible organisms.
Dosage and Administration
Adults: one tablet twice daily for 7–14 days depending on infection type; DS (double-strength) used for more severe infections or urinary tract infections. Take with food and plenty of water.
Interaction
May enhance anticoagulant effect of warfarin. Increases methotrexate toxicity. Phenytoin levels may increase. Reduces efficacy of cyclosporin. May cause hyperkalaemia with ACE inhibitors or potassium-sparing diuretics.
Contraindications
Contraindicated in patients with severe hepatic or renal impairment, megaloblastic anaemia due to folate deficiency, hypersensitivity to sulphonamides or trimethoprim, and during the first trimester and near term of pregnancy.
Side Effects
Nausea, vomiting, rash (including severe reactions such as Stevens-Johnson syndrome), haematological disorders, and crystalluria. Renal function may be impaired.
Pregnancy and Lactation
Avoid during the first trimester (teratogenic risk of trimethoprim) and near term (risk of neonatal jaundice). Not recommended during breastfeeding.
Precautions and Warnings
Maintain adequate fluid intake to prevent crystalluria. Monitor full blood count and renal function with prolonged use. Use with caution in elderly and folate-deficient patients.
Storage Conditions
Store below 30°C in a cool, dry place. Keep away from moisture and light.
Frequently Asked Questions
Why should plenty of water be taken with co-trimoxazole?
Adequate hydration prevents crystalluria — the precipitation of drug crystals in the urinary tract, which can cause kidney damage or urinary blockage.
What is the difference between Cotrim and Cotrim DS?
Cotrim DS (double-strength) contains twice the concentration of both sulphamethoxazole and trimethoprim, allowing fewer tablets per day for certain infections.
This content is for informational purposes only and does not substitute professional medical advice. Please consult a registered physician before taking any medication.
