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- Product ID: Cephradine
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Abac 125mg/5ml Suspension
Generic Name: Cephradine BP 125mg per 5ml
Manufacturer: Beximco Pharmaceuticals Ltd.
Drug Class: First-Generation Cephalosporin Antibiotic
Dosage Form: Oral Suspension (Powder for Reconstitution)
Prescription Status: Prescription Only (Rx)
Mechanism of Action
Cephradine is a bactericidal first-generation cephalosporin. It inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), preventing cross-linking of peptidoglycan chains and causing osmotic lysis of susceptible bacteria. It is active against many gram-positive cocci and some gram-negative organisms.
Spectrum of Activity
| Sensitivity | Organisms |
|---|---|
| Susceptible | Staphylococcus aureus (MSSA), Streptococcus pyogenes, S. pneumoniae, E. coli, Klebsiella spp., Proteus mirabilis, H. influenzae |
| Resistant | MRSA, Pseudomonas aeruginosa, Enterococcus spp., most ESBL-producing organisms |
Indications
- Upper respiratory tract infections (pharyngitis, tonsillitis, sinusitis, otitis media)
- Lower respiratory tract infections (bronchitis, pneumonia)
- Urinary tract infections (UTIs) — uncomplicated cystitis
- Skin and soft tissue infections (impetigo, cellulitis, wound infections)
- Bone and joint infections (adjunctive oral step-down therapy)
Dosage and Administration
| Patient Group | Dose | Frequency |
|---|---|---|
| Children (9–50 kg) | 25–50 mg/kg/day (in divided doses) | Every 6 or 12 hours |
| Severe infections (children) | Up to 100 mg/kg/day | Every 6 hours (max 4g/day) |
| Adults (mild–moderate) | 250–500 mg | Every 6 hours |
Reconstitute with boiled and cooled water to the mark on the bottle. Shake well before each dose. Complete the full course.
Important Notice for Diabetic Patients
- Diabetic foot and skin infections: Effective for mild-to-moderate gram-positive infections, but MRSA and gram-negative organisms (common in diabetic foot infections) are resistant — culture and sensitivity testing is essential
- Urinary tract infections in diabetes: Suitable for uncomplicated lower UTI; complicated or recurrent UTIs require urine C&S — ESBL-producing E. coli and Klebsiella may be resistant
- Renal dose adjustment (diabetic nephropathy):
CrCl >20 ml/min: standard dose; CrCl 5–20 ml/min: reduce by 50%; CrCl <5 ml/min: avoid or use with caution - False-positive urine glucose: Use glucose oxidase dipstick tests only — copper reduction methods (Clinitest, Benedict's) give false-positive results with cephradine
- Infection-related hyperglycaemia: Active infection may worsen glycaemic control — intensify blood glucose monitoring during antibiotic treatment
Contraindications
- Hypersensitivity to cephalosporins
- Immediate hypersensitivity to penicillins (cross-reactivity ~1–2%)
- Severe renal failure (dose adjustment required)
Side Effects
| System | Side Effects |
|---|---|
| Gastrointestinal | Nausea, vomiting, diarrhoea, abdominal discomfort, C. difficile colitis (rare) |
| Hypersensitivity | Rash, urticaria, pruritus, anaphylaxis (rare) |
| Haematological | Eosinophilia, neutropenia, positive Coombs test (rare) |
| Hepatic/Renal | Transient elevation of liver enzymes; increased creatinine at high doses |
Storage
Dry powder: Store below 30°C away from moisture and light. After reconstitution: Refrigerate (2–8°C), use within 7 days. Shake well before each use. Keep out of reach of children.
Medical Disclaimer
The information provided here is for educational and informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your doctor or pharmacist before starting, stopping, or altering any medication. Antibiotic therapy should be guided by culture and sensitivity results where possible. DiabetesStore.com.bd does not endorse self-medication. Seek immediate medical attention in case of any adverse reaction.
