Acilog Mix 30%+70% 3 ml biopen Injection

Acilog Mix 30/70 – Biphasic Insulin Aspart 3ml Biopen by ACI Limited

What is Acilog Mix 30/70 Biopen?

Acilog Mix 30/70 is a premixed biphasic insulin aspart analogue manufactured by ACI Limited, Bangladesh. Each ml contains 30 IU soluble insulin aspart (rapid-acting, post-meal coverage) and 70 IU protamine crystallised insulin aspart (intermediate-acting, basal coverage) — the same biphasic formulation as the originator NovoMix 30, at a locally manufactured price point. The Biopen format is a disposable pre-filled pen for convenient once or twice-daily injection. As an aspart-based premix, Acilog Mix 30/70 can be injected immediately before meals (unlike human insulin 30/70, which requires 30-minute pre-meal timing), offering greater flexibility. Requires resuspension before each use.

Generic Name and Composition

Each ml: 30 IU soluble insulin aspart (rapid, onset 10–20 min, peak 1–3 hrs) + 70 IU protamine crystallised insulin aspart (intermediate, onset 1–4 hrs, duration 18–24 hrs). Both fractions are the same aspart molecule — the protamine fraction is crystallised with protamine to slow absorption, creating the intermediate-acting basal component. After resuspension and injection, the soluble fraction covers post-meal spikes while the crystallised fraction provides sustained basal coverage.

Indications

• Type 2 diabetes — twice-daily premixed analogue insulin regimen
• Type 1 diabetes — when a premixed analogue approach is clinically appropriate
• Patients who prefer pre-meal flexibility vs. fixed 30-min pre-meal timing of human insulin premixes
• Patients seeking an affordable locally manufactured analogue premix alternative to NovoMix 30

How It Works — Mechanism of Action

Soluble aspart (30%): Rapidly absorbed (10–20 min onset), peaks at 1–3 hours to control post-meal glucose. Protamine aspart (70%): Slowly absorbed over 18–24 hours, providing sustained basal insulin activity between meals and overnight. Both components activate insulin receptors: GLUT-4-mediated glucose uptake, suppression of hepatic glucose output, and glycogen synthesis.

Dosage and Administration

Starting dose (Type 2): 6 IU twice daily (before breakfast and before dinner); titrate by 2 IU every 3 days. Resuspension: Roll the biopen 10 times then invert 10 times until the suspension is uniformly milky — essential before every injection. Inject immediately before meals (0–15 minutes). Inject SC (abdomen, thigh, or upper arm). Do not administer IV or IM.

Side Effects

Very common: Hypoglycaemia. Common: Injection site reactions, lipohypertrophy, weight gain. Uncommon: Lipoatrophy, oedema, visual changes. Rare: Generalised hypersensitivity, anaphylaxis.

Drug Interactions

Enhance effect: OADs, GLP-1 agonists, SGLT-2 inhibitors, ACE inhibitors, MAO inhibitors, salicylates, alcohol. Reduce effect: Corticosteroids, glucagon, thyroid hormones, sympathomimetics, thiazides. Mask symptoms: Beta-blockers, clonidine.

Contraindications

• Hypersensitivity to insulin aspart, protamine, or any excipient
• Active hypoglycaemia; subcutaneous use only

Pregnancy and Lactation

Pregnancy: Insulin aspart is considered safe; specialist supervision required. Lactation: No clinically significant infant exposure via breast milk expected.

Precautions and Warnings

• Always resuspend before use: Roll 10x, invert 10x until uniformly milky. Failure to resuspend delivers incorrect 30/70 ratio.
• Inject within 15 minutes before meals — faster than human insulin premixes but still requires pre-meal timing.
• Do not freeze. Protect from direct sunlight.
• Discard 28 days after first use.

Overdose

Hypoglycaemia. Mild: oral glucose. Severe: IV dextrose or IM glucagon 1 mg. The protamine aspart fraction extends hypoglycaemia risk for up to 24 hours — monitor glucose closely.

Storage Instructions

• Unopened: 2–8 degrees C. Do not freeze.
• In-use biopen: Below 30 degrees C. Do not refrigerate.
• Discard 28 days after first use.

Frequently Asked Questions

Q1: Is Acilog Mix 30/70 the same as NovoMix 30?
Yes — both contain biphasic insulin aspart: 30% soluble + 70% protamine crystallised insulin aspart at 100 IU/ml. Acilog Mix 30/70 is manufactured by ACI Limited, Bangladesh, offering the same clinical formulation as the imported NovoMix 30 (Novo Nordisk, Denmark) at a significantly more affordable price.

Q2: How is Acilog Mix 30/70 different from Diasulin 30/70 or Humulin 70/30?
Acilog Mix uses insulin aspart (analogue, onset 10–20 min) while Diasulin and Humulin use regular human insulin (onset 30 min). Acilog Mix can be injected just before eating; human insulin premixes require 30-minute pre-meal injection. Aspart-based premixes generally provide better post-meal glucose control.

Q3: What is the Acilog Biopen?
The Biopen is ACI Limited's disposable pre-filled insulin pen. It contains 3 ml (300 IU) of Acilog Mix 30/70 and allows convenient dose dialling and injection without manual syringe drawing. No cartridge loading required — attach a needle, prime, dial, and inject.

Q4: Can I switch from Acilog Mix 30/70 Biopen to Acilog vial?
Both contain the same Acilog Mix 30/70 formulation. The vial requires a U-100 insulin syringe; the biopen is a self-contained pen device. Clinical effect per unit is equivalent. Switching format does not require dose adjustment — but always confirm with your pharmacist or doctor.

Medical Disclaimer: For educational purposes only. Acilog Mix is Rx-only. Consult your diabetologist before starting or changing insulin therapy. DiabetesStore.com.bd is a licensed online pharmacy in Bangladesh.