Acilog Mix 30%+70% 3 ml vial Injection

Acilog Mix 30/70 – Biphasic Insulin Aspart 30% + 70% 100 IU/ml Injection (3 ml Vial)

What is Acilog Mix 30/70 Vial?

Acilog Mix 30/70 is a premixed biphasic insulin aspart analogue in a 3 ml vial, manufactured by ACI Limited, Bangladesh. It contains 30% rapid-acting soluble insulin aspart and 70% intermediate-acting protamine crystallised insulin aspart (NovoMix-type) — providing fast post-meal glucose control alongside sustained inter-meal and overnight basal coverage in a single injection. Unlike premixed human insulins (30/70 NPH/regular), Acilog Mix uses insulin aspart as both fractions — giving a faster onset (10–20 min vs 30 min for regular insulin) while retaining the convenience of a fixed premix. Acilog Mix is ACI Limited's locally manufactured biosimilar to NovoMix 30 (Novo Nordisk), offering equivalent clinical action at a lower price. The 3 ml vial is used with U-100 insulin syringes.

Generic Name and Composition

Each ml contains: 30 IU soluble insulin aspart + 70 IU protamine crystallised insulin aspart = 100 IU/ml. The soluble aspart fraction acts rapidly (onset 10–20 min, peak 1–3 hrs) for immediate post-meal glucose control. The protamine crystallised fraction is absorbed slowly, providing an intermediate-acting profile (peak 4–10 hrs, duration up to 24 hrs) that bridges between meals and overnight. The aspart-based premix offers a faster post-meal onset advantage over classic 30/70 human insulin premixes.

Indications

• Type 2 diabetes requiring premixed twice-daily insulin therapy
• Patients who want faster post-meal coverage than NPH-based premixed human insulins provide
• Patients transitioning from twice-daily human insulin premix to an analogue premix
• Type 1 diabetes — only in select, closely monitored regimens under specialist supervision

How It Works — Mechanism of Action

After SC injection from the 3 ml vial using a syringe, the soluble aspart fraction rapidly dissociates and peaks at 1–3 hours — controlling the glucose rise from the adjacent meal with faster action than regular human insulin. The protamine crystallised fraction dissolves gradually over 12–24 hours, suppressing hepatic glucose output and maintaining inter-meal glucose control. The combined action profile covers two meals per day with twice-daily dosing.

Dosage and Administration

Inject 0–10 minutes before main meals (or immediately after). Starting dose for Type 2 (insulin-naive): typically 6–12 IU twice daily, adjusted per physician guidance. Draw up with a U-100 syringe from the 3 ml vial. Resuspend by rolling the vial 10 times before each draw — the suspension must appear uniformly milky white. Inject SC into abdomen, thigh, or upper arm. Rotate sites consistently.

Side Effects

Very common: Hypoglycaemia. Common: Injection site reactions, lipohypertrophy, weight gain. Uncommon: Lipoatrophy, peripheral oedema, visual changes at treatment initiation. Rare: Hypersensitivity, anaphylaxis.

Drug Interactions

Enhance hypoglycaemia: OADs, GLP-1 agonists, SGLT-2 inhibitors, ACE inhibitors, MAO inhibitors, salicylates, alcohol. Reduce effect: Corticosteroids, glucagon, thyroid hormones, sympathomimetics, thiazides, oral contraceptives. Mask symptoms: Beta-blockers, clonidine.

Contraindications

• Active hypoglycaemia
• Hypersensitivity to insulin aspart or any excipient
• Intravenous administration (vial content is for SC injection only)

Pregnancy and Lactation

Pregnancy: Limited data on biphasic aspart in pregnancy; NPH-based premixes or basal-bolus regimens often preferred. Consult specialist. Lactation: Not expected to pass into breast milk in clinically significant amounts.

Precautions and Warnings

• Resuspend before every draw — roll vial 10 times; do not shake. Discard if suspension appears lumpy or non-uniform.
• Eat within 10 minutes of injection — faster onset than human insulin means delayed meals risk hypoglycaemia.
• Do not mix with other insulins in the same syringe.
• Do not freeze. Protect from light and heat.

Overdose

Hypoglycaemia. Mild: oral glucose or carbohydrate. Severe: IV dextrose 20–50% or IM glucagon 1 mg. The intermediate component can sustain hypoglycaemia for 12–24 hours — prolonged monitoring and repeat treatment may be needed.

Storage Instructions

• Unopened vial: 2–8 degrees C. Do not freeze.
• In-use vial: Below 25 degrees C. Protect from light.
• Discard 28 days after first use.

Frequently Asked Questions

Q1: What is the difference between Acilog Mix vial and Acilog Mix Biopen?
Both contain the same biphasic insulin aspart 30/70 at 100 IU/ml. The 3 ml vial is drawn up with a U-100 syringe — suited for patients accustomed to vial-and-syringe technique or those on higher doses. The Acilog Mix Biopen is a pre-filled disposable pen — more convenient, no syringe needed. Choice depends on patient skill, preference, and dose requirements.

Q2: How is Acilog Mix different from Acilog Mix Biopen (41645)?
Acilog Mix vial (41644) is a 3 ml vial for syringe use. Acilog Mix Biopen (41645) is a 3 ml pre-filled pen for pen needle injection — no syringe required. Same insulin, different delivery format.

Q3: Is Acilog Mix 30/70 the same as NovoMix 30?
Yes — both contain biphasic insulin aspart (30% soluble + 70% protamine crystallised) at 100 IU/ml. NovoMix 30 is manufactured by Novo Nordisk (Denmark); Acilog Mix is manufactured by ACI Limited (Bangladesh). As a locally produced biosimilar, the clinical effect per unit is equivalent at a lower price point.

Q4: Why is a biphasic aspart premix (Acilog Mix) better than a classic human insulin premix (30/70 NPH)?
Acilog Mix (biphasic aspart) has a faster onset (10–20 min vs 30 min) and can be injected immediately before or after meals, offering more flexibility. The rapid aspart fraction also produces a more pronounced early glucose-lowering peak. Classic 30/70 NPH premixes require injection 30 minutes before eating, which is less convenient. For patients with irregular meal timing, the aspart premix is generally more manageable.

Medical Disclaimer: For educational purposes only. Acilog Mix is Rx-only. Consult your diabetologist before starting or changing insulin therapy. DiabetesStore.com.bd is a licensed online pharmacy in Bangladesh.