Adinir 300mg Capsule

Adinir 300mg Capsule — Composition & Pharmacology

Generic Name: Cefdinir 300mg
Manufacturer: Beximco Pharmaceuticals Ltd.
Drug Class: Third-Generation Oral Cephalosporin Antibiotic
Dosage Form: Oral Capsule

Cefdinir is a broad-spectrum, semi-synthetic, third-generation oral cephalosporin antibiotic. It exerts bactericidal activity by inhibiting bacterial cell wall synthesis via binding to penicillin-binding proteins (PBPs). Cefdinir is stable against many beta-lactamases and is active against a wide range of gram-positive and gram-negative pathogens.

Indications

Adinir 300mg (Cefdinir) is indicated for treatment of mild to moderate infections caused by susceptible strains of designated microorganisms:

• Community-Acquired Pneumonia: Caused by Haemophilus influenzae, Streptococcus pneumoniae, Moraxella catarrhalis
• Acute Exacerbations of Chronic Bronchitis
• Acute Maxillary Sinusitis
• Pharyngitis & Tonsillitis caused by Streptococcus pyogenes
• Uncomplicated Skin & Skin Structure Infections
• Otitis Media

Dosage & Administration

Adults & Adolescents (≥13 years):

• Community-acquired pneumonia, skin infections: 300mg every 12 hours for 10 days, or 600mg once daily for 10 days
• Acute exacerbations of chronic bronchitis, sinusitis: 300mg every 12 hours for 5–10 days, or 600mg once daily for 10 days
• Pharyngitis/tonsillitis: 300mg every 12 hours for 5–10 days, or 600mg once daily for 10 days

Administration: May be taken with or without food. Antacids containing magnesium or aluminium and iron supplements should be taken at least 2 hours before or after cefdinir as they can reduce absorption.

Contraindications & Precautions

• Contraindicated in patients with known hypersensitivity to cefdinir, other cephalosporins, or penicillins
• Dose adjustment required in renal impairment (CrCl <30 mL/min)
• Caution in patients with history of GI disease or colitis
• Note: Cefdinir may cause reddish stools (due to formation of a non-absorbable complex with iron in diet); inform patients

Side Effects

Common: Diarrhoea, nausea, vaginal infection, headache. Reddish discoloration of stools may occur. Hypersensitivity reactions (rash, urticaria) may occur. Serious but rare: Clostridioides difficile-associated diarrhoea, Stevens-Johnson syndrome.

Drug Interactions

Antacids containing aluminium or magnesium reduce cefdinir absorption. Iron supplements and iron-fortified foods reduce absorption. Probenecid increases cefdinir plasma levels.

Storage

Store at room temperature below 25°C, away from moisture and direct sunlight. Keep out of reach of children.

Medical Disclaimer: This information is for reference purposes only and is not a substitute for professional medical advice. Cefdinir is a prescription antibiotic. Always consult a qualified physician before use. Completing the full prescribed course is essential. Diabetesstore.com.bd strongly recommends obtaining a valid prescription for this medication.