Amdocal 5 mg Tablet — Amlodipine Besilate by Beximco Pharmaceuticals

Indications

Essential hypertension: Amdocal is efficacious as monotherapy in the treatment of hypertension. It may be used in combination with other antihypertensive agents. Angina pectoris: Amdocal is indicated for the treatment of chronic stable angina pectoris and is efficacious as monotherapy. Vasospastic angina: Amdocal is indicated for the treatment of confirmed or suspected vasospastic angina.

Pharmacology

Amlodipine is a dihydropyridine calcium-channel blocker with a long duration of action, used for the treatment of hypertension and angina pectoris. Administration of Amlodipine results primarily in vasodilation, with reduced peripheral resistance, blood pressure and afterload, increased coronary blood flow and a reflex increase in coronary heart rate. This in turn results in an increase in myocardial oxygen supply and cardiac output.

Dosage & Administration

Hypertension: Usual dose is 5 mg once daily. The maximum dose is 10 mg once daily. Elderly patients with hepatic insufficiency may be started on 2.5 mg once daily. Angina (Chronic stable or Vasospastic): 5 to 10 mg once daily, using the lower dose for elderly and in patients with hepatic insufficiency. Most patients require 10 mg. May be taken without regard to meals.

Side Effects

Most common adverse effects are associated with vasodilatory action: dizziness, flushing, headache, hypotension and peripheral edema. Gastrointestinal disturbances, increased micturition frequency, lethargy, eye pain and mental depression may also occur. Rashes, fever and abnormalities in liver function due to hypersensitivity reaction may also occur.

Precautions & Warnings

Precaution should be taken in patients with hepatic impairment and during pregnancy and breast feeding. The combination with beta-blockers should be avoided in patients with markedly impaired cardiac left ventricular function.

Contraindications

Hypersensitivity to dihydropyridine derivatives. Pregnant woman.

Pregnancy & Lactation

Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women. Amlodipine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is recommended that nursing be discontinued while Amlodipine is administered.

Storage Conditions

Keep all medicines out of reach of children. Store in a cool & dry place, protected from light.

Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or pharmacist before starting any medication.