Angilock Plus 100/12.5 Tablet

Overview

Angilock Plus 100 mg+12.5 mg Tablet combines Losartan Potassium and Hydrochlorothiazide, manufactured by Square Pharmaceuticals PLC. It is used for the treatment of hypertension.

Indications

Angilock Plus is indicated for the treatment of hypertension. It is also indicated to reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy.

Pharmacology

Losartan selectively blocks the binding of angiotensin II to the AT1 receptor, blocking its vasoconstrictor and aldosterone-secreting effects. Hydrochlorothiazide is a thiazide diuretic that increases excretion of sodium and chloride, reducing plasma volume and lowering blood pressure. The combination provides complementary blood pressure control.

Dosage and Administration

A patient whose blood pressure is not adequately controlled with Losartan 100 mg monotherapy may be switched to the 100/12.5 combination once daily. In patients with left ventricular hypertrophy, 100/12.5 may be used if additional blood pressure reduction beyond 50/12.5 is needed, followed by 100/25 if required. May be administered with or without food, and with other antihypertensive agents.

Interaction

Concomitant use of potassium-sparing diuretics, potassium supplements, or salt substitutes containing potassium may increase serum potassium. NSAIDs such as indomethacin may blunt the antihypertensive effect. Alcohol, barbiturates or narcotics may potentiate orthostatic hypotension. Dosage adjustment of antidiabetic drugs may be required.

Contraindications

Contraindicated in patients hypersensitive to any component of this product, and in patients with anuria or hypersensitivity to other sulfonamide-derived drugs due to the Hydrochlorothiazide component.

Side Effects

Side effects are usually mild and include symptomatic hypotension, dizziness, vertigo, headache, and occasional hyperkalaemia. Less commonly: gastrointestinal disturbances, palpitation, oedema, rash and sleep disorders.

Pregnancy and Lactation

Angiotensin-II receptor antagonists should be avoided in pregnancy unless essential, as they may adversely affect fetal and neonatal blood pressure control and renal function. Not recommended during breastfeeding.

Precautions and Warnings

Monitor serum electrolytes periodically. Hypokalemia may rarely develop, especially with brisk diuresis or severe cirrhosis. Use with caution in impaired renal function and symptomatic hypotension.

Storage Conditions

Do not store above 30°C. Keep out of the reach of children.

Frequently Asked Questions

What is Angilock Plus 100 mg+12.5 mg used for?
It is used to treat hypertension, including in patients not adequately controlled on Losartan 100 mg alone.

Is this dose suitable for elderly patients?
The maximum dose of 100/25 should not be used as initial therapy in elderly patients, but lower combinations may be appropriate as guided by a physician.

This content is for informational purposes only and does not substitute professional medical advice. Please consult a registered physician before taking any medication.