Angilock Plus 100/25 Tablet

Overview

Angilock Plus 100 mg+25 mg Tablet is the highest-strength combination of Losartan Potassium and Hydrochlorothiazide, manufactured by Square Pharmaceuticals PLC. It is used for the treatment of hypertension that is not adequately controlled on lower doses.

Indications

Angilock Plus 100/25 is indicated for the treatment of hypertension in patients whose blood pressure is not adequately controlled on lower strength combinations. It is also indicated to reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy.

Pharmacology

Losartan selectively blocks the binding of angiotensin II to the AT1 receptor, blocking its vasoconstrictor and aldosterone-secreting effects. Hydrochlorothiazide is a thiazide diuretic that increases excretion of sodium and chloride, reducing plasma volume and lowering blood pressure. At this highest approved dose, the combination provides maximum antihypertensive efficacy.

Dosage and Administration

The maximum dose of 100/25 once daily is used in patients whose blood pressure is not adequately controlled on lower combinations. This dose should not be used as initial therapy. May be administered with or without food, and with other antihypertensive agents.

Interaction

Concomitant use of potassium-sparing diuretics, potassium supplements, or salt substitutes containing potassium may increase serum potassium. NSAIDs such as indomethacin may blunt the antihypertensive effect. Alcohol, barbiturates or narcotics may potentiate orthostatic hypotension. Dosage adjustment of antidiabetic drugs may be required.

Contraindications

Contraindicated in patients hypersensitive to any component of this product, and in patients with anuria or hypersensitivity to other sulfonamide-derived drugs due to the Hydrochlorothiazide component.

Side Effects

Side effects are usually mild and include symptomatic hypotension, dizziness, vertigo, headache, and hyperkalaemia or hypokalaemia. Less commonly: gastrointestinal disturbances, palpitation, oedema, rash and sleep disorders.

Pregnancy and Lactation

Angiotensin-II receptor antagonists should be avoided in pregnancy unless essential, as they may adversely affect fetal and neonatal blood pressure control and renal function. Not recommended during breastfeeding.

Precautions and Warnings

Monitor serum electrolytes periodically, particularly at this higher dose. Hypokalemia may develop, especially with brisk diuresis or severe cirrhosis. Use with caution in impaired renal function and symptomatic hypotension. Not recommended as initial therapy in elderly patients.

Storage Conditions

Do not store above 30°C. Keep out of the reach of children.

Frequently Asked Questions

What is Angilock Plus 100 mg+25 mg used for?
It is the highest-strength combination used for hypertension when lower doses do not adequately control blood pressure.

Can this dose be used as first-line treatment?
No, the 100/25 combination should not be used as initial therapy and is reserved for patients not controlled on lower strengths.

This content is for informational purposes only and does not substitute professional medical advice. Please consult a registered physician before taking any medication.