Antazol 0.1% Nasal Drop

Overview

Antazol 0.1% Nasal Drop is a Xylometazoline Hydrochloride preparation manufactured by Square Pharmaceuticals PLC. It is a sympathomimetic agent with marked alpha-adrenergic activity used to relieve nasal congestion in adults and children over 12 years of age.

Indications

Antazol is indicated for nasal congestion associated with colds, rhinitis, sinusitis, and headache, as well as tubal block and serous otitis media associated with nasal congestion.

Pharmacology

Xylometazoline is a selective agonist at alpha2B-adrenoceptors, with affinity at alpha1A-, alpha2A-, alpha2C-, alpha1B-, and alpha1D-adrenoceptors. Activation of these receptors causes vasoconstriction of the blood vessels lining the nasal mucosa, decongesting the nose and surrounding pharyngeal area and allowing easier breathing. The effect begins within a few minutes and persists for several hours.

Dosage and Administration

Adults and children over 12 years: 2 to 3 drops in each nostril, two to three times daily. This 0.1% strength should not be used in children under 12 years of age; the 0.05% strength is recommended for younger children.

Interaction

No clinically significant drug interactions have been reported with Xylometazoline nasal drops.

Contraindications

Contraindicated in patients with transsphenoidal hypophysectomy or surgery exposing the dura mater, and in patients hypersensitive to Xylometazoline. Each bottle should be used by one person only to prevent cross-infection.

Side Effects

Occasional side effects include a burning sensation in the nose and throat, local irritation, nausea, and dryness of the nasal mucosa.

Pregnancy and Lactation

Pregnancy Category C. Xylometazoline should not be used during pregnancy. Use during breastfeeding should only occur on a doctor's advice.

Precautions and Warnings

Should not be used in children below 12 years of age. Avoid long-term use in chronic rhinitis, as prolonged use may cause rebound congestion and drug-induced rhinitis. Decongestants should not be used for more than seven consecutive days.

Storage Conditions

Protect from light. For hygiene reasons, do not use the bottle more than 28 days after opening.

Frequently Asked Questions

Q: What is the difference between Antazol 0.05% and 0.1%?
A: The 0.1% strength is intended for adults and children over 12 years, while the 0.05% strength is for children between 6 months and 12 years of age.

Q: How long can I use Antazol Nasal Drop continuously?
A: It should not be used for more than seven consecutive days, as prolonged use may cause rebound nasal congestion.

This content is for informational purposes only and is not a substitute for professional medical advice. Please consult a registered physician before starting, stopping, or changing any medication.