- Stock: In Stock
- Brand: Beximco Pharmaceutical
- Product ID: Linezolid
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Arlin 400mg Tablet — Linezolid 400mg | Beximco Pharmaceuticals
| Generic Name | Linezolid 400 mg |
| Dosage Form | Film-coated Tablet |
| Drug Class | Oxazolidinone Antibiotic |
| Manufacturer | Beximco Pharmaceuticals Ltd. |
| Prescription Status | Prescription Only — Specialist Use |
| Oral Bioavailability | ~100% — equivalent to IV linezolid |
Overview
Arlin 400mg contains Linezolid 400mg — an oxazolidinone antibiotic active against drug-resistant Gram-positive bacteria including MRSA, VRE, and penicillin-resistant streptococci. The 400mg strength is used for uncomplicated skin and soft tissue infections (SSTIs) in adults (where 400mg BD achieves adequate tissue concentrations for mild-moderate infections), and as the standard dose for paediatric patients dosed by weight. Linezolid 400mg twice daily provides serum concentrations effective against most Gram-positive pathogens while reducing the risk of adverse effects compared to the 600mg dose used for more severe infections. Linezolid's near-complete oral bioavailability (~100%) allows effective outpatient oral treatment of infections that would otherwise require IV therapy.
Mechanism of Action
Linezolid inhibits bacterial protein synthesis by uniquely binding to the 23S ribosomal RNA of the 50S subunit, preventing formation of the 70S initiation complex — a mechanism entirely distinct from all other antibiotic classes, meaning no cross-resistance. Predominantly bacteriostatic against staphylococci and enterococci, bactericidal against streptococci. Mitochondrial ribosomal inhibition explains key toxicities (thrombocytopenia, lactic acidosis, peripheral neuropathy) with prolonged use.
Indications for Linezolid 400mg
- Uncomplicated skin and soft tissue infections (SSTIs) — mild-moderate MRSA SSTIs in adults (400mg BD)
- Community-acquired pneumonia — mild-moderate severity where penicillin-resistant S. pneumoniae suspected
- Paediatric dosing — weight-based linezolid therapy in children
- Note: for severe or complicated infections (pneumonia, bacteraemia, osteomyelitis, VRE), the 600mg dose is required
Dosage and Administration
| Indication | Dose | Frequency | Duration |
|---|---|---|---|
| Uncomplicated SSTI (adults) | 400 mg | Twice daily (BD) | 10–14 days |
| CAP — mild-moderate (adults) | 400 mg | Twice daily | 10–14 days |
| Paediatric ≥12 years | 600 mg | Twice daily (use 600mg tablet) | As per indication |
| Paediatric 5–11 years | 10 mg/kg | Every 8 hours | As directed (use suspension) |
Take with or without food. Avoid tyramine-rich foods during therapy (aged cheeses, fermented meats, wines, soy sauce) — linezolid is a weak reversible MAO inhibitor. Complete the full prescribed course.
Critical Warnings — Diabetic Patients
- Metformin — withhold during linezolid: Both linezolid and metformin impair mitochondrial function through different mechanisms — concurrent use increases lactic acidosis risk significantly. Withhold metformin for the entire duration of linezolid therapy; use insulin or alternative OHA. Inform your prescribing physician about metformin use.
- SSRIs/SNRIs — serotonin syndrome risk: Linezolid's MAO inhibitory activity combined with serotonergic drugs (sertraline, fluoxetine, duloxetine, venlafaxine — commonly used for diabetic neuropathic pain or depression) can cause serotonin syndrome. Physician must assess before prescribing linezolid.
- Peripheral neuropathy: May worsen pre-existing diabetic peripheral neuropathy — monitor for new/worsening symptoms; stop if deterioration occurs.
- Platelet monitoring: Check FBC with platelets weekly for courses exceeding 2 weeks.
Key Drug Interactions
- Metformin — lactic acidosis (withhold metformin)
- SSRIs / SNRIs — serotonin syndrome (avoid combination)
- Tramadol, pethidine — serotonin syndrome
- Sympathomimetics, tyramine-rich foods — hypertensive crisis (MAO inhibition)
- Rifampicin — reduces linezolid levels ~30%
Side Effects
Common: nausea, diarrhoea, headache, elevated LFTs. Uncommon: thrombocytopenia (monitor FBC weekly for prolonged courses), skin rash. Rare with short courses but important with prolonged use (>28 days): peripheral neuropathy, optic neuropathy, lactic acidosis. Serotonin syndrome — with concurrent serotonergic drugs.
Storage
Store below 25°C in a dry place. Protect from light. Keep out of reach of children.
Medical Disclaimer: For educational purposes only. Linezolid has critical interactions with metformin and SSRIs/SNRIs — both extremely common in diabetic patients. Always disclose all medications to your prescribing physician. Prescription required.
