- Stock: In Stock
- Brand: Beximco Pharmaceutical
- Product ID: Atorvastatin calcium
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Atova 40 mg Tablet — Atorvastatin | Beximco Pharmaceuticals
| Generic Name | Atorvastatin Calcium |
| Strength | 40 mg |
| Dosage Form | Film-Coated Tablet |
| Manufacturer | Beximco Pharmaceuticals Ltd. |
| Therapeutic Class | HMG-CoA Reductase Inhibitor (High-Intensity Statin) |
| Pack Size | 30 Tablets per Box |
| Availability | In Stock — Available Online |
Overview
Atova 40 mg Tablet contains Atorvastatin Calcium 40 mg, manufactured by Beximco Pharmaceuticals Ltd. This is a high-intensity statin dose that reduces LDL cholesterol by approximately 49%. Atova 40 mg is indicated for patients who require aggressive lipid lowering — including those with established cardiovascular disease (post-MI, post-stroke), T2DM aged 40–75 with high cardiovascular risk, familial hypercholesterolaemia, and patients who fail to reach LDL targets on lower doses. Per ADA guidelines, high-intensity statin therapy (40–80 mg Atorvastatin) is recommended for T2DM patients with established CVD or multiple major risk factors.
Indications
- Secondary Prevention — post-myocardial infarction, post-stroke, post-coronary revascularisation
- T2DM with established CVD — ADA recommends high-intensity statin (40–80 mg) for T2DM + established ASCVD
- T2DM aged 40–75 with multiple CV risk factors — strong evidence for high-intensity statin
- Familial Hypercholesterolaemia — requires high-intensity statin as baseline
- LDL target not met on Atova 10 or 20 mg — step-up high-intensity therapy
Key Benefits
- ~49% LDL reduction — classified as high-intensity statin therapy
- Dramatically reduces risk of major cardiovascular events in high-risk patients
- Preferred statin dose for T2DM patients with any prior cardiac event
- Once-daily dosing at any time of day
- Manufactured under WHO-GMP standards by Beximco Pharmaceuticals
Pharmacology
Atorvastatin at 40 mg achieves near-maximal inhibition of HMG-CoA reductase in the liver, producing the strongest LDL-lowering effect within the standard dosing range. High-intensity statin therapy at this dose also maximally upregulates hepatic LDL receptors, accelerating LDL particle clearance from plasma. The pleiotropic cardiovascular benefits — plaque stabilisation, reduced vascular inflammation (CRP suppression), improved endothelial NO release, and anti-thrombotic effects — are also more pronounced at 40 mg than at lower doses, contributing to the superior cardiovascular outcomes seen in landmark trials (PROVE-IT, TNT) with high-intensity statin therapy.
Dosage & Administration
| Patient Group | Recommended Dose | LDL Target |
|---|---|---|
| T2DM with established CVD (ADA) | 40–80 mg once daily | <70 mg/dL |
| Secondary prevention (post-MI/stroke) | 40–80 mg once daily | <70 mg/dL |
| T2DM 40–75 with multiple risk factors | 40 mg once daily | <100 mg/dL |
| Familial Hypercholesterolaemia | 40–80 mg once daily | As per specialist |
Take once daily at any time, with or without food.
Contraindications
- Active liver disease or persistent liver enzyme elevation
- Pregnancy (Category X — absolute contraindication)
- Breastfeeding
- Hypersensitivity to Atorvastatin
Warnings
- Myopathy/Rhabdomyolysis: Risk is higher at 40 mg than at lower doses — especially with concomitant CYP3A4 inhibitors. Report muscle pain, weakness, or dark urine immediately.
- Drug Interactions: At 40 mg, pharmacokinetic interactions with CYP3A4 inhibitors are clinically significant — review all concurrent medications.
- Pregnancy: Absolute contraindication — discontinue immediately if pregnancy occurs.
- Blood Glucose: Statins may modestly raise HbA1c; benefit far exceeds this risk in T2DM patients.
Drug Interactions
| Drug | Interaction |
|---|---|
| Clarithromycin / HIV Protease Inhibitors | Markedly increase Atorvastatin at 40 mg — high myopathy risk; withhold statin or choose alternative antibiotic |
| Itraconazole / Ketoconazole | Strong CYP3A4 inhibition — avoid; use alternative antifungal if possible |
| Cyclosporine / Tacrolimus | Dramatically increase statin exposure — contraindicated at 40 mg |
| Amlodipine | Increases Atorvastatin ~18% — limit to 40 mg/day with amlodipine |
| Rifampicin | Induces CYP3A4 — reduces statin efficacy; monitor LDL closely |
Side Effects
Common: Arthralgia, myalgia, diarrhoea, nasopharyngitis, headache, insomnia, nausea.
Uncommon: Elevated liver enzymes, hyperglycaemia, muscle cramps.
Rare: Myopathy, rhabdomyolysis (report severe muscle pain + dark urine immediately), hepatitis.
Storage
- Below 30°C, protected from moisture and sunlight. Keep in original blister. Out of reach of children.
Frequently Asked Questions
Q1: Why has my doctor prescribed Atova 40 mg?
Atova 40 mg is prescribed when you have established heart disease (post-MI, post-stroke), are a T2DM patient with high cardiovascular risk, or have not reached your LDL target on lower doses. International guidelines recommend high-intensity statins (40–80 mg Atorvastatin) for these high-risk patients to maximally reduce heart attack and stroke risk.
Q2: How is Atova 40 mg different from Atova 10 or 20 mg?
Atova 40 mg reduces LDL by ~49%, compared to ~37% (10 mg) and ~43% (20 mg). It is classified as a high-intensity statin and is recommended for patients who need the strongest possible cholesterol lowering and cardiovascular protection.
Q3: Is muscle pain more common at 40 mg?
Yes, myalgia risk increases slightly with higher statin doses. If you experience unexplained significant muscle pain, weakness, or dark urine, stop Atova and consult your physician immediately. Routine CK monitoring is not needed unless symptoms occur.
Q4: Can I take Atova 40 mg together with Metformin and other diabetes medicines?
Yes — Metformin, diabetes medicines, and Atorvastatin do not have pharmacokinetic interactions and are frequently co-prescribed. Inform your physician of all medications you take so they can check for interactions with other drugs (especially antibiotics, antifungals).
Q5: Is Atova 40 mg prescription-only?
Yes — Rx medicine. Valid physician prescription required. Upload it when ordering from DiabetesStore.com.bd.
Medical Disclaimer: Educational purposes only. Always consult a registered physician or pharmacist before starting, changing, or stopping any medication.
