Axodin 120mg Tablet — Fexofenadine Hydrochloride 120mg by Beximco

Axodin 120mg Tablet — Fexofenadine Hydrochloride 120mg | Beximco Pharmaceuticals

Overview

Axodin 120mg contains Fexofenadine Hydrochloride 120 mg — the once-daily strength of Beximco's Axodin antihistamine range. A single 120mg tablet provides 24-hour allergy relief, making it the most convenient dosing option for patients managing seasonal allergic rhinitis (hay fever). As a second-generation antihistamine, fexofenadine is non-sedating at therapeutic doses — patients can take it in the morning and remain fully alert throughout the day. The 120mg once-daily dose is clinically equivalent to 60mg twice-daily for allergic rhinitis.

Axodin Range at a Glance

Indications

• Seasonal Allergic Rhinitis — sneezing, runny nose, nasal congestion, itchy/watery eyes, itchy nose/throat due to pollen, dust mites, animal dander
• Perennial Allergic Rhinitis — year-round symptoms from persistent allergen exposure
• Allergic Conjunctivitis — itchy, red, watery eyes associated with allergic rhinitis

Pharmacology

Fexofenadine is the pharmacologically active carboxylic acid metabolite of terfenadine. It blocks peripheral H1 histamine receptors selectively, inhibiting histamine-mediated allergic cascade: vasodilation, plasma exudation, glandular hypersecretion, pruritus, and smooth muscle contraction. Key pharmacokinetic advantages: onset 1 hour; peak 2–3 hours; half-life ~14 hours (supporting once-daily 120mg dosing); no hepatic CYP450 metabolism — minimal drug-drug interactions; no cardiac effects — does not prolong QT interval (unlike terfenadine/astemizole).

Dosage & Administration

Take with water. Do not take with fruit juices (grapefruit, orange, apple) — they reduce fexofenadine absorption by up to 36%. Take at a consistent time each day, ideally morning. Can be taken with or without food.

Special Note for Diabetic Patients

Fexofenadine has no effect on blood glucose, insulin action, or glycaemic control. Axodin 120mg is safe for diabetic patients. Its once-daily dosing fits easily into a morning medication routine alongside metformin, glipizide, or other diabetes medicines. No dose adjustment is needed in patients with type 2 diabetes.

Side Effects

• Common (≥1%): Headache, dizziness, nausea, drowsiness (at doses above 120mg), fatigue
• Rare: Insomnia, nervousness, sleep disturbance
• Very rare: Hypersensitivity (rash, urticaria, anaphylaxis)
• CNS: Minimal sedation at 120mg — does not impair driving or cognitive function

Drug Interactions

Storage

• Store below 30°C in a dry place, protected from light. Keep out of reach of children.

FAQ

Q1: What is the best time to take Axodin 120mg?
Take it once daily in the morning with a glass of water (not juice). Morning dosing provides all-day allergy protection during peak pollen/allergen exposure hours. Consistent timing each day maximises efficacy.

Q2: Can I take Axodin 120mg every day long-term?
Yes. Fexofenadine is safe for continuous long-term use during allergy seasons. Unlike some older antihistamines, it does not cause tolerance (tachyphylaxis). It is one of the preferred antihistamines for chronic allergic rhinitis management.

Q3: Is Axodin 120mg safe during pregnancy?
Fexofenadine is generally avoided in the first trimester unless clearly necessary. In later pregnancy, it should be used only on physician advice as safety data are limited. Consult your physician before taking any antihistamine during pregnancy.

Q4: Why can't I drink orange juice with fexofenadine?
Fruit juices (particularly grapefruit, orange, and apple juice) contain compounds that inhibit OATP (organic anion transporting polypeptide) transporters in the intestinal wall, significantly reducing fexofenadine absorption — by up to 36%. Always take Axodin with plain water for full therapeutic benefit.

Medical Disclaimer: Educational information only. Use under the guidance of a licensed physician or pharmacist.