Citicol IM/IV inj

Indications

Atova EZ tablet is indicated for: * Primary Hyperlipidemia: reduction of elevated total-C, LDL-C, apolipoprotein B, triglycerides, and non-HDL-C, and to increase HDL-C in patients with primary (heterozygous familial and non-familial) hyperlipidemia or mixed hyperlipidemia * Homozygous Familial Hypercholesterolemia (HoFH): reduction of elevated total-C and LDL-C as an adjunct to other lipid lowering treatments

Pharmacology

Atorvastatin inhibits HMG-CoA reductase, thereby reducing hepatic cholesterol synthesis and increasing LDL receptor expression for enhanced LDL catabolism. Ezetimibe reduces blood cholesterol by inhibiting cholesterol absorption by the small intestine via the sterol transporter Niemann-Pick C1-Like 1 (NPC1L1). This inhibits intestinal cholesterol absorption by approximately 54%, complementary to the mechanism of statins.

Dosage & Administration

Recommended starting dose is 10/10 mg or 20/10 mg once daily with or without food. Patients requiring a larger LDL-C reduction (>55%) may start at 40/10 mg daily. Dosage range is 10/10 mg to 80/10 mg daily. Lipid levels should be analyzed within 2 or more weeks after initiation and dosage adjusted accordingly. Homozygous FH: 40/10 mg or 80/10 mg daily.

Side Effects

Common side effects: rhabdomyolysis, myopathy, liver enzyme abnormalities, myalgia, abdominal pain, increased hepatic enzymes.

Precautions & Warnings

Cases of myopathy, including rhabdomyolysis, have been reported. Atova EZ therapy should be temporarily withheld or discontinued in any patient with an acute, serious condition suggestive of myopathy. Liver enzyme tests should be obtained prior to initiating therapy and repeated as clinically indicated. Active liver disease or unexplained persistent transaminase elevations are contraindications.

Contraindications

Active liver disease or unexplained persistent elevations of hepatic transaminase levels. Hypersensitivity to any component of this preparation. Contraindicated during pregnancy (Category X).

Pregnancy & Lactation

Contraindicated in women who are or may become pregnant. Lipid-lowering drugs offer no benefit during pregnancy. It is not known whether atorvastatin is excreted in human milk.

Storage Conditions

Do not store above 30°C. Keep in a dry place. Protect from light and keep out of the reach of children.

Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or pharmacist before starting any medication.