- Stock: In Stock
- Brand: Square Pharmaceuticals
- Product ID: Gliclazide
100% Secure Payment
bKash | Nagad | Cards via SSLCommerz | COD
Monthly Medicines Available | Free Delivery on Eligible Orders
| Generic Name | Gliclazide |
| Strength | 80 mg |
| Dosage Form | Tablet |
| Manufacturer | Square Pharmaceuticals PLC |
| Therapeutic Class | Sulfonylurea Antidiabetic Agent |
| Pack Size | Each box contains tablets in blister strips |
Overview
Comprid 80 mg Tablet contains Gliclazide, a second-generation sulfonylurea antidiabetic agent manufactured by Square Pharmaceuticals PLC. It stimulates insulin secretion from pancreatic beta cells and is used in the management of type 2 diabetes mellitus in adults when diet and exercise alone are insufficient.
Dosage and Administration
Adults: 40–80 mg daily in one or two doses, up to 320 mg/day in divided doses as needed. Take with meals.
Interaction
Risk of hypoglycaemia increased with other antidiabetic drugs, alcohol, NSAIDs, sulfonamides, and fibrates. Rifampicin and barbiturates may reduce efficacy. Fluconazole and other CYP2C9 inhibitors may increase gliclazide levels.
Contraindications
Contraindicated in type 1 diabetes, diabetic ketoacidosis, severe renal/hepatic impairment, hypersensitivity to sulfonylureas, and during pregnancy and breastfeeding.
Side Effects
Hypoglycaemia is the most important adverse effect. GI disturbances, weight gain, and rarely haematological reactions may occur.
Pregnancy and Lactation
Contraindicated in pregnancy; insulin is preferred. Avoid during breastfeeding.
Precautions and Warnings
Take consistently with meals. Monitor blood glucose regularly. Educate patient on recognising and treating hypoglycaemia. Use with caution in the elderly (hypoglycaemia risk).
Storage Conditions
Store below 30°C in a cool, dry place away from direct sunlight.
Frequently Asked Questions
How does gliclazide lower blood sugar?
Gliclazide stimulates insulin release from pancreatic beta cells by blocking ATP-sensitive potassium channels, leading to membrane depolarisation and calcium-mediated insulin secretion.
Can gliclazide be used in elderly patients?
Yes, but with close monitoring for hypoglycaemia, which is more dangerous in elderly patients due to impaired counter-regulatory responses; a lower starting dose and frequent blood glucose checks are advisable.
This content is for informational purposes only and does not substitute professional medical advice. Please consult a registered physician before taking any medication.
