Dapaglip 10mg Tablet

What is Dapaglip?

Dapaglip is a brand of Dapagliflozin manufactured by Incepta Pharmaceuticals Ltd. It belongs to the SGLT2 inhibitor class, used to improve blood glucose control in adults with type 2 diabetes mellitus by promoting glucose excretion through the kidneys.

Generic Name and Composition

Each tablet contains 10 mg of Dapagliflozin (as propanediol monohydrate).

Indications

• Type 2 diabetes mellitus, as monotherapy or combined with other antidiabetic agents (including metformin, insulin)
• Also used to reduce risk of cardiovascular events and to manage certain heart failure and chronic kidney disease cases, as determined by a physician

How It Works — Mechanism of Action

Dapagliflozin inhibits SGLT2 in the renal proximal tubules, reducing glucose reabsorption and increasing urinary glucose excretion. This lowers blood glucose independent of insulin secretion or action, with additional modest benefits for body weight and blood pressure.

Dosage and Administration

• Dosage is individualized by a physician; typically taken once daily in the morning, with or without food.
• Swallow the tablet whole with water.
• Maintain adequate hydration, as the medicine increases urination.
• Do not change the dose without consulting your physician.

Side Effects

Common: Urinary tract infections, genital fungal infections, increased urination, thirst.

Uncommon: Volume depletion/dehydration, hypotension, dyslipidemia.

Rare: Diabetic ketoacidosis (sometimes with near-normal blood glucose), Fournier's gangrene, severe urinary tract infections.

Drug Interactions

May enhance hypoglycemia: Insulin, sulfonylureas — dose adjustment of these agents may be needed when combined with dapagliflozin.

May increase dehydration risk: Diuretics (e.g., furosemide, thiazides).

Other considerations: Inform your doctor of all medicines you are taking.

Contraindications

• Known hypersensitivity to dapagliflozin or any excipient
• Severe renal impairment or dialysis-dependent kidney disease
• Type 1 diabetes mellitus or diabetic ketoacidosis

Pregnancy and Lactation

Dapagliflozin is generally not recommended during pregnancy or breastfeeding. Insulin is typically preferred for glycemic control in these situations. Consult your physician for an appropriate alternative if pregnant or breastfeeding.

Precautions and Warnings

• Maintain good hydration, especially in hot weather, during illness, or with reduced food/fluid intake.
• Monitor for signs of urinary tract or genital infections and seek prompt treatment.
• Seek immediate medical attention for symptoms of ketoacidosis even if blood glucose is not very high.
• Temporarily discontinue before major surgery or during acute serious illness, as advised by your physician.
• Use with caution in elderly patients and those at risk of volume depletion.

Overdose

Limited data exists on dapagliflozin overdose. Management is supportive, focusing on monitoring for hypoglycemia, dehydration, and electrolyte imbalance, with appropriate clinical intervention as needed. Seek immediate medical attention in case of suspected overdose.

Storage Instructions

• Store below 30°C in a dry place, protected from light.
• Keep out of reach of children.
• Do not use after the expiry date printed on the pack.

Frequently Asked Questions

Q1: Why does Dapaglip increase urination?
Dapaglip works by causing the kidneys to remove excess glucose through urine, which naturally increases urine output. Staying well-hydrated helps offset this effect.

Q2: Can Dapaglip cause low blood sugar on its own?
Used alone, the risk of hypoglycemia is low. Risk increases when combined with insulin or sulfonylureas.

Q3: Why am I more prone to genital or urinary infections on Dapaglip?
The increased glucose in urine can promote growth of yeast and bacteria. Good hygiene and prompt reporting of symptoms help manage this risk.

Q4: How is Dapaglip different from Empatab?
Both Dapaglip (dapagliflozin) and Empatab (empagliflozin) are SGLT2 inhibitors with a similar mechanism; they differ mainly in dosing and specific approved indications. Your physician will recommend the most suitable option.

Medical Disclaimer

This product is available by prescription only (Rx). The information provided is for educational purposes and does not replace professional medical advice. Always consult a registered physician before starting, stopping, or changing any diabetes therapy. DiabetesStore.com.bd is a licensed online pharmacy in Bangladesh.