Eromycin 100ml Dry Syrup

Overview

Eromycin Dry Powder for Oral Suspension contains Erythromycin 125 mg per 5 ml when reconstituted, manufactured by Square Pharmaceuticals PLC. Erythromycin is a broad-spectrum macrolide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. The dry syrup formulation is designed for paediatric use, providing a palatable liquid form for children. Indicated for respiratory tract infections, skin and soft tissue infections, pertussis (whooping cough), Campylobacter enteritis, chlamydia, and as a penicillin alternative in penicillin-allergic patients.

Dosage and Administration

Children: 30–50 mg/kg/day in divided doses every 6–8 hours (typically 125–250 mg every 6 hours depending on age and weight), or as directed. Reconstitute with clean water to the required volume mark. Shake well before each use.

Interaction

Erythromycin is a potent CYP3A4 inhibitor — major interactions with statins (simvastatin, lovastatin), cisapride, pimozide, ergotamine (avoid co-administration — risk of serious adverse effects), cyclosporin, warfarin, digoxin, theophylline, and carbamazepine (levels of these drugs increase). QT interval prolongation risk with other QT-prolonging drugs.

Contraindications

Contraindicated in hepatic disease (erythromycin estolate form), known hypersensitivity to macrolide antibiotics, and concurrent use with cisapride, pimozide, ergotamine, or astemizole.

Side Effects

Nausea, vomiting, abdominal cramps, and diarrhoea are most common. Cholestatic jaundice (with estolate form). Cardiac arrhythmias (QT prolongation) with high doses. Reversible hearing loss with high doses.

Pregnancy and Lactation

Erythromycin is generally considered one of the safer antibiotics in pregnancy (base form); avoid the estolate form. Compatible with breastfeeding — small amounts pass into breast milk.

Precautions and Warnings

Take on an empty stomach (or as directed). Complete the full course. Inform physician of all concurrent medications due to significant drug interaction potential.

Storage Conditions

After reconstitution, store at 2–8°C (refrigerate). Use within 14 days of reconstitution. Keep out of the reach of children.

Frequently Asked Questions

Why is erythromycin considered an alternative to penicillin?
Erythromycin targets many of the same respiratory and soft-tissue pathogens as penicillin but via a different mechanism; it is effective in patients with penicillin allergy and is particularly useful for atypical organisms (Mycoplasma, Chlamydia, Legionella) that penicillins cannot treat.

Why must the dry syrup be refrigerated after reconstitution?
Reconstituted erythromycin suspension is chemically unstable at room temperature and degrades rapidly; refrigeration significantly slows degradation, maintaining potency for 14 days after mixing.

This content is for informational purposes only and does not substitute professional medical advice. Please consult a registered physician before taking any medication.