Evo 500 mg Tablet, 1 strip

Indications

Betapro tablet is indicated in-

- Hypertension
- Angina
- Moderate to severe heart failure

Betapro is not recommended for the emergency treatment of hypertensive crises.

Pharmacology

Bisoprolol Fumarate is the most selective beta1 blocker. It displays highest level of affinity for the beta1 receptor than any other beta-blocker available up to now. Selectively blocks beta1 adrenergic receptor in the heart and vascular smooth muscle and reduces heart rate and cardiac output resulting in decrease of arterial hypertension.

Bisoprolol is almost completely (>90%) absorbed from the gastrointestinal tract. The high absorption rate and the small first-pass effect (<10%) lead to an absolute bioavailability of 88%. Concomitant food intake does not affect the absorption. The medium distribution volume is 3.5 L/kg. Bisoprolol is metabolized via oxidative pathways. The clearance of Bisoprolol is balanced between renal elimination of the unchanged molecule (~50%) and hepatic metabolism (~50%) to metabolites which are also renally excreted. Bisoprolol has an elimination half-life of 10-12 hours.

Dosage & Administration

Adult: In the treatment of mild to moderate hypertension, Bisoprolol fumarate must be individualized to the needs of the patient. The usual starting dose is 5 mg once daily either added to a diuretic or alone. If the response to 5 mg is inadequate, the dose may be increased to 10 mg and then, if necessary, to 20 mg once daily. An appropriate interval for dose titration is 2 weeks.

Patients With Renal or Hepatic Impairment: The initial daily dose should be 5 mg. Caution must be used in dose titration.

Geriatrics: In the elderly, it is not usually necessary to adjust the dose, unless there is also significant renal or hepatic dysfunction.

Side Effects

Fatigue, dizziness, headache, disturbances of the gut such as nausea, vomiting, diarrhea, constipation or abdominal pain. Cold or numb extremities, e.g; hands and feet. Muscle weakness or cramps. Slower than normal heart breathing difficulties due to a narrowing of the airways (bronchospasm) in people with asthma or COPD.

Precautions & Warnings

Use caution in adjusting the dose of Betapro in patients with renal or hepatic impairment. While taking beta-blockers, patients with a history of severe anaphylactic reaction to a variety of allergens may be more reactive to repeated challenge, accidental, diagnostic, or therapeutic. Such patients may be unresponsive to the usual doses of epinephrine used to treat allergic reactions.

Contraindications

In patients with cardiogenic shock, overt heart failure, second or third degree A-V block, right ventricular failure secondary to pulmonary hypertension and sinus bradycardia.

Pregnancy & Lactation

Pregnancy: Bisoprolol fumarate should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Lactation: Small amounts of bisoprolol fumarate have been detected in the milk of lactating rats. It is not known whether this drug is excreted in human milk. If use of bisoprolol fumarate is considered essential, then mothers should stop nursing.

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or pharmacist before starting any medication.