Glucomet XR 750 mg Tablet

Glucomet XR 750 mg Tablet — Metformin Hydrochloride (Extended Release)

Overview

Glucomet XR 750 is a higher-strength extended-release metformin tablet from Aristopharma Limited, designed for patients who need a stronger once-daily dose than the XR 500 mg strength provides.

Mechanism of Action

Metformin reduces hepatic glucose production, decreases intestinal glucose absorption, and improves peripheral insulin sensitivity. The extended-release matrix releases the drug gradually, supporting once-daily dosing with steadier blood levels.

Indications

Glucomet XR 750 is indicated for type 2 diabetes mellitus in patients requiring a higher extended-release metformin dose, typically after the XR 500 mg strength has been well tolerated.

Dosage and Administration

Typically taken once daily with the evening meal; tablets must be swallowed whole and never crushed, split, or chewed. Dose adjustments should follow physician guidance.

Contraindications

Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²), metabolic acidosis including diabetic ketoacidosis, and known hypersensitivity to metformin.

Side Effects

Generally good gastrointestinal tolerability, though nausea, diarrhea, or abdominal discomfort can occur, particularly when stepping up from a lower strength. Long-term use may reduce vitamin B12 absorption.

Drug Interactions

Iodinated contrast media require temporary discontinuation of metformin. Alcohol intake should be limited. Disclose all current medications and supplements to your physician or pharmacist.

Special Precautions

Patients may occasionally notice the tablet matrix in stool; this is expected and does not indicate reduced effectiveness. Renal function should be reassessed before stepping up to this higher strength.

Storage

Store below 30°C in a dry place, protected from light. Keep out of reach of children.

Frequently Asked Questions

Q1: When would my doctor prescribe Glucomet XR 750 instead of XR 500?
It is typically prescribed when the XR 500 mg strength does not provide adequate glycemic control and has been well tolerated.

Q2: Can I split a Glucomet XR 750 tablet to reduce my dose?
No, extended-release tablets must not be split, crushed, or chewed as this disrupts the controlled-release mechanism.

Q3: How does Glucomet XR 750 compare to taking two XR 500 tablets?
Your physician will determine the most appropriate strength; do not substitute strengths without medical guidance.

Q4: Is Glucomet XR 750 suitable for long-term use?
Yes, once an effective and well-tolerated dose is established, it is commonly used for long-term maintenance therapy.

Medical Disclaimer: This information is provided for educational purposes only and does not replace professional medical advice. Always consult a registered physician or pharmacist before starting, stopping, or changing any medication. Dosage and suitability vary by individual health condition.