Glyset Mix Injection

What is Glyset Mix?

Glyset Mix is a premixed (biphasic) insulin analog manufactured by Incepta Pharmaceuticals Ltd., combining 30% rapid-acting insulin aspart with 70% intermediate-acting protamine-crystallised insulin aspart in a vial. It provides both mealtime and basal glucose coverage in one injection, with a faster onset than premixed human insulin formulations.

Generic Name and Composition

Each mL contains 100 IU of Biphasic Insulin Aspart, consisting of 30% soluble insulin aspart and 70% protamine-crystallised insulin aspart, supplied in a 10 mL vial.

Indications

• Type 1 diabetes mellitus, as part of a structured insulin regimen
• Type 2 diabetes mellitus when oral antidiabetic agents are insufficient to control blood glucose
• Patients who prefer or require a simplified premixed insulin regimen with a faster mealtime action than human premixed insulin

How It Works — Mechanism of Action

The rapid-acting insulin aspart component acts quickly to control blood glucose rise after meals, while the protamine-crystallised component provides a delayed, prolonged intermediate effect. Together, they lower blood glucose by promoting cellular glucose uptake and suppressing hepatic glucose production over an extended period.

Dosage and Administration

• Dosage is strictly individualized by a physician based on blood glucose monitoring, body weight, and meal patterns.
• Administered by subcutaneous injection using a syringe, typically immediately before or just after a meal (0-15 minutes), before breakfast and/or dinner.
• Gently roll/invert the vial before each use to re-suspend the cloudy insulin evenly — do not shake vigorously.
• Use a new sterile syringe and needle for each injection.
• Rotate injection sites within the same body region to reduce lipodystrophy.

Side Effects

Common: Hypoglycemia, injection site reactions (redness, swelling, itching), lipodystrophy with repeated injections at the same site.

Uncommon: Weight gain, peripheral edema (especially when starting therapy).

Rare: Severe allergic reactions (generalized rash, angioedema, anaphylaxis), hypokalemia.

Drug Interactions

May increase hypoglycemia risk: Oral antidiabetic agents, ACE inhibitors, salicylates, alcohol.

May reduce insulin effect / raise blood glucose: Corticosteroids, thiazide diuretics, thyroid hormones, oral contraceptives.

Other considerations: Beta-blockers may mask symptoms of hypoglycemia; inform your doctor of all medicines you are taking.

Contraindications

• Known hypersensitivity to insulin aspart or any excipient
• Episodes of hypoglycemia requiring caution in dosing adjustment

Pregnancy and Lactation

Insulin aspart-based formulations are generally considered safe for use during pregnancy and breastfeeding under close physician supervision. Dose requirements often change during pregnancy and require close monitoring.

Precautions and Warnings

• Never share vials or syringes between patients due to infection transmission risk.
• Inject close to mealtime (0-15 minutes before eating) — delaying the meal after injection increases hypoglycemia risk.
• Closely monitor blood glucose, especially when changing dose, insulin brand, meal timing, or activity/diet patterns.
• Be aware of signs of hypoglycemia (sweating, palpitations, confusion) and carry a fast-acting sugar source.
• Store correctly — refrigerate unopened vials, keep in-use vials at room temperature, away from direct heat and sunlight.

Overdose

Overdose may cause severe hypoglycemia, with symptoms ranging from sweating and confusion to seizures and loss of consciousness. Mild cases can be managed with oral glucose; severe cases require immediate medical attention, including intravenous glucose or glucagon administration.

Storage Instructions

• Store unopened vials in a refrigerator (2-8°C); do not freeze.
• Once in use, the vial may be kept at room temperature (below 30°C) for up to 4 weeks, away from direct heat and light.
• Keep out of reach of children.
• Do not use after the expiry date printed on the pack.

Frequently Asked Questions

Q1: Why does Glyset Mix appear cloudy?
The protamine-crystallised component is a suspension, giving the insulin a cloudy appearance. Gently roll or invert the vial to re-suspend it evenly before each injection — do not shake vigorously.

Q2: How is the vial different from the Penset?
Both contain the same insulin; the vial requires a separate syringe for dosing, while the Penset offers a more portable, prefilled pen device.

Q3: How is Glyset Mix different from Maxsulin 30/70?
Both are premixed insulins in a 30/70 ratio; Glyset Mix uses insulin aspart analog (faster onset, can be taken closer to meals), while Maxsulin 30/70 uses regular human insulin (slower onset, requires injection 30 minutes before meals).

Q4: How does Glyset Mix compare to Glyset R?
Glyset R contains only rapid-acting insulin aspart for mealtime coverage, while Glyset Mix combines rapid-acting and intermediate-acting insulin aspart for both mealtime and basal coverage in one injection.

Medical Disclaimer

This product is available by prescription only (Rx) and should be used under medical supervision. The information provided is for educational purposes and does not replace professional medical advice. Always consult a registered physician before starting, stopping, or changing any insulin therapy. DiabetesStore.com.bd is a licensed online pharmacy in Bangladesh.