- Stock: In Stock
- Brand: Square Pharmaceuticals
- Product ID: Metronidazole + Neomycin Sulphate + Polymyxin B + Nystatin
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| Generic Name | Metronidazole + Neomycin Sulphate + Polymyxin B Sulphate + Nystatin |
|---|---|
| Strength | Metronidazole 200 mg + Neomycin Sulphate 35,000 IU + Polymyxin B Sulphate 35,000 IU + Nystatin 100,000 IU per suppository |
| Dosage Form | Vaginal Suppository |
| Manufacturer | Square Pharmaceuticals PLC |
| Therapeutic Class | Drugs used in Vaginal and Vulval conditions |
| Pack Size | 2 x 6 (12's) |
Overview
Gynepro Vaginal Suppository is a combination antimicrobial preparation containing Metronidazole 200 mg, Neomycin Sulphate 35,000 IU, Polymyxin B Sulphate 35,000 IU, and Nystatin 100,000 IU per suppository. This combination provides broad-spectrum coverage against the common causative organisms of vaginal infections: Metronidazole (a nitroimidazole) is active against anaerobic bacteria and protozoa; Nystatin (a polyene antibiotic) provides antifungal activity; Neomycin (an aminoglycoside) is bactericidal against certain Gram-positive and Gram-negative organisms; and Polymyxin B is active against Gram-negative organisms including Pseudomonas aeruginosa. Gynepro is indicated for vaginal trichomoniasis, vaginal leucorrhoeas, and mixed vaginal infections of fungal or bacterial origin.
Dosage and Administration
Insert one suppository deep into the vagina at bedtime for 12 consecutive days, or as directed by the physician. Ensure proper personal hygiene throughout the course of treatment. Complete the full course even if symptoms improve before the end of treatment.
Interaction
No significant systemic drug interactions are expected from vaginal Metronidazole due to minimal systemic absorption; however, patients receiving systemic anticoagulants such as warfarin should be monitored, as topical Metronidazole may potentiate anticoagulant effects in some cases. Consult the physician if taking any concurrent medications.
Contraindications
Gynepro is contraindicated in patients with known hypersensitivity to Metronidazole, Neomycin Sulphate, Polymyxin B Sulphate, or Nystatin, or to any component of the formulation.
Side Effects
Gynepro is generally well tolerated. Skin rash and urticaria may occur rarely. Local irritation or burning sensation at the site of application may also occur. Discontinue use and consult a physician if a significant allergic reaction develops.
Pregnancy and Lactation
Caution should be exercised when using Gynepro during pregnancy and lactation. The use of Metronidazole-containing preparations during the first trimester of pregnancy is generally avoided. Consult a physician before use during pregnancy or breastfeeding.
Precautions and Warnings
Use with caution in patients with renal impairment, as Neomycin may be absorbed and cause nephrotoxicity or ototoxicity in susceptible individuals. Avoid contact with eyes. For vaginal use only; not for oral, ophthalmic, or rectal use. Complete the full prescribed course to prevent recurrence of infection. Do not use tampons during treatment.
Storage Conditions
Store in a cool and dry place, away from light. Keep out of the reach of children.
Frequently Asked Questions
Q: What infections does Gynepro Vaginal Suppository treat?
Gynepro is used to treat vaginal trichomoniasis (caused by the Trichomonas vaginalis parasite), vaginal leucorrhoeas (abnormal vaginal discharge), and mixed vaginal infections caused by a combination of fungal and bacterial organisms. Its four-component formula targets a broad range of pathogens simultaneously.
Q: How long should Gynepro Vaginal Suppository be used?
One suppository should be inserted into the vagina at bedtime for 12 consecutive days or as directed by the physician. It is important to complete the full 12-day course even if symptoms resolve earlier, to ensure complete eradication of the infection and prevent recurrence.
