- Stock: In Stock
- Brand: Square Pharmaceuticals
- Product ID: Loperamide
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| Generic Name | Loperamide Hydrochloride |
|---|---|
| Strength | 2 mg |
| Dosage Form | Capsule |
| Manufacturer | Square Pharmaceuticals PLC |
| Therapeutic Class | Anti-diarrhoeal, Anti-motility drugs |
| Pack Size | 20 x 10 (200's) |
Overview
Imotil Capsule contains Loperamide Hydrochloride 2 mg, an anti-diarrhoeal agent that works by inhibiting the peristaltic activity of the intestinal smooth muscle through interactions with both cholinergic and non-cholinergic neuronal mechanisms. Loperamide binds to opiate receptors in the gut wall, reducing propulsive peristalsis and increasing intestinal transit time. It also increases the tone of the anal sphincter and inhibits electrolyte and fluid secretion in the intestine. Unlike opioid analgesics, Loperamide does not act centrally due to its high affinity for the gut wall and extensive first-pass metabolism. Imotil is indicated for acute and chronic diarrhoea, abdominal cramps associated with diarrhoea, Crohn's disease, post-gastric surgery diarrhoea, and ulcerative colitis.
Dosage and Administration
Acute diarrhoea — Adults: 2 capsules initially, followed by 1 capsule after each loose stool. Usual dosage 3–4 capsules per day; maximum 8 capsules per day.
Acute diarrhoea — Children (9–12 years): 1 capsule after each loose stool until diarrhoea is controlled; maximum 6 capsules per day.
Acute diarrhoea — Children (5–9 years): 1 capsule 4 times daily until diarrhoea is controlled; maximum 4 capsules per day.
Chronic diarrhoea — Adults: 2–4 capsules daily in divided doses, depending on severity.
Chronic diarrhoea — Children: 1–2 capsules daily depending on severity, or as directed by physician.
Interaction
No clinically significant drug interactions with Loperamide Hydrochloride have been formally documented. Patients on concurrent medications should consult their physician before use.
Contraindications
Imotil is contraindicated in patients with known hypersensitivity to Loperamide Hydrochloride and in patients who must avoid constipation. It should not be used alone in acute dysentery characterised by blood in the stool and elevated body temperature.
Side Effects
Reported side effects include abdominal pain, dry mouth, dizziness, fatigue, skin rashes, and other gastrointestinal disturbances. Overdosage may result in constipation, CNS depression, and nausea.
Pregnancy and Lactation
The safety of Loperamide Hydrochloride in human pregnancy has not been established; use during pregnancy is not advisable. Although the fraction excreted in human breast milk is extremely low, caution is advised when administering to nursing mothers.
Precautions and Warnings
Use with caution in patients with severe hepatic impairment. Do not use alone in acute dysentery (bloody diarrhoea with fever). Keep all medicines out of the reach of children. Store in a cool and dry place protected from light.
Storage Conditions
Store in a cool and dry place, protected from light. Keep all medicines out of the reach of children.
Frequently Asked Questions
Q: What is Imotil 2 mg used for?
Imotil (Loperamide 2 mg) is used to control acute and chronic diarrhoea, relieve abdominal cramps associated with diarrhoea, and manage diarrhoea in conditions such as Crohn's disease, ulcerative colitis, and post-gastric surgery. It slows intestinal movement and reduces fluid loss, helping to firm stools and reduce the frequency of bowel movements.
Q: Is Imotil safe for children?
Imotil can be used in children aged 5 years and above, at reduced doses. Children aged 5–9 years may take 1 capsule 4 times daily (maximum 4 capsules/day); children aged 9–12 years may take 1 capsule after each loose stool (maximum 6 capsules/day). It should not be used in children under 5 years without physician guidance, and should never be used in acute dysentery (bloody diarrhoea with fever).
