Insulet 30%+70% in 100 IU/ml Injection

Insulet 30/70 – Biphasic Human Insulin 100 IU/ml by Healthcare Pharmaceuticals

What is Insulet 30/70?

Insulet 30/70 is a premixed biphasic human insulin manufactured by Healthcare Pharmaceuticals Ltd., Bangladesh. Each ml provides 30 IU soluble regular human insulin (short-acting) and 70 IU isophane human insulin (NPH, intermediate-acting) — both produced by recombinant DNA technology. This fixed-ratio combination delivers both post-meal and between-meal glucose control in a single twice-daily injection. Insulet 30/70 is part of Healthcare Pharmaceuticals' comprehensive insulin portfolio, which also includes Insulet N (isophane), Insulet 50/50, Insulet ASP (insulin aspart), and Insulet GN (insulin glargine) — offering patients a complete locally manufactured insulin range.

Generic Name and Composition

Each ml: 30 IU soluble human insulin (rDNA) — rapid component, onset 30 min, peak 1–3 hrs, duration 6–8 hrs; 70 IU isophane human insulin (rDNA) — basal component, onset 1–2 hrs, peak 4–8 hrs, duration 12–18 hrs. As a suspension, the product has a cloudy appearance due to protamine-insulin crystals and requires thorough resuspension before each use.

Indications

• Type 2 diabetes mellitus requiring twice-daily premixed insulin
• Type 1 diabetes where a fixed premixed regimen is appropriate
• Insulin initiation in patients transitioning from oral antidiabetics
• Patients seeking a complete locally manufactured insulin brand

How It Works — Mechanism of Action

The soluble fraction provides rapid post-meal glucose control (peak 1–3 hrs). The isophane fraction provides sustained basal coverage (peak 4–8 hrs, duration 12–18 hrs). Both components bind insulin receptors: promote GLUT-4 glucose uptake, suppress hepatic gluconeogenesis, and stimulate glycogen synthesis — controlling both post-prandial and fasting glucose levels throughout the day.

Dosage and Administration

Typical starting dose (Type 2): 0.2 IU/kg/day split into 2 injections before breakfast and dinner. Titration: Increase by 2 IU every 3 days based on glucose monitoring. Technique: Roll 10 times, invert 10 times until uniformly milky. Inject SC 30 minutes before meals (abdomen, thigh, or upper arm) using a U-100 insulin syringe.

Side Effects

Very common: Hypoglycaemia. Common: Injection site reactions, lipohypertrophy, weight gain, oedema. Uncommon: Lipoatrophy, visual disturbances at initiation. Rare: Systemic hypersensitivity, anaphylaxis.

Drug Interactions

Potentiate effect: OADs, GLP-1 agonists, SGLT-2 inhibitors, ACE inhibitors, MAO inhibitors, salicylates, alcohol. Reduce effect: Corticosteroids, glucagon, thyroid hormones, sympathomimetics, thiazides, oral contraceptives. Mask symptoms: Beta-blockers, clonidine.

Contraindications

• Hypersensitivity to human insulin or excipients
• Active hypoglycaemia; IV or IM use

Pregnancy and Lactation

Pregnancy: Human insulin is preferred — use under specialist supervision with dose adjustment. Lactation: No clinically significant breast milk transfer.

Precautions and Warnings

• Resuspend before every injection: roll 10x, invert 10x.
• Inject 30 minutes before meals — human insulin onset requires pre-meal timing.
• Do not mix with other insulins in the same syringe.
• Rotate injection sites. Do not freeze.

Overdose

Hypoglycaemia. Mild: oral glucose. Severe: IV dextrose or IM glucagon. Monitor closely — NPH component prolongs hypoglycaemia risk for 12–18 hrs.

Storage Instructions

• Unopened: 2–8°C. Do not freeze.
• In-use vial: Below 25°C. Protect from light and heat.
• Discard 28 days after first use.

Frequently Asked Questions

Q1: What other Insulet insulin products are available?
Healthcare Pharmaceuticals produces a comprehensive insulin range under the Insulet brand: Insulet 30/70 (biphasic human insulin), Insulet 50/50 (equal-ratio premix), Insulet N (isophane/NPH basal), Insulet ASP (insulin aspart, rapid-acting analogue), and Insulet GN (insulin glargine, long-acting basal analogue). This allows patients to stay within one trusted local brand across different insulin types.

Q2: Is Insulet 30/70 equivalent to Humulin 70/30 or Mixtard 30?
Yes — all contain the same formulation: 30% soluble regular human insulin + 70% isophane (NPH) human insulin at 100 IU/ml. Clinical efficacy per unit is equivalent. Insulet 30/70 offers locally manufactured quality at a more affordable price point.

Q3: What is the difference between Insulet 30/70 and Insulet 50/50?
Insulet 30/70 has 30% rapid + 70% basal — provides more sustained basal coverage, suitable for most Type 2 patients on a twice-daily regimen. Insulet 50/50 has equal rapid and basal fractions — sometimes used when post-meal control needs to be stronger, particularly in patients with high post-prandial glucose spikes relative to fasting levels.

Q4: Can I switch from Insulet 30/70 to Insulet ASP or Insulet GN?
Yes, but always under medical supervision. Insulet ASP (insulin aspart) is a rapid-acting analogue for bolus use; Insulet GN (insulin glargine) is a long-acting basal. Switching from a premixed to separate basal-bolus regimen is a significant clinical change requiring dose recalculation by your diabetologist.

Medical Disclaimer: For educational purposes only. Insulet is Rx-only. Consult your diabetologist before starting or changing insulin therapy. DiabetesStore.com.bd is a licensed online pharmacy in Bangladesh.