Lesovir-C Tablet 7's pack

Lesovir 90mg/400mg — Composition & Pharmacology

Generic Name: Ledipasvir + Sofosbuvir
Manufacturer: Beximco Pharmaceuticals Ltd.
Drug Class: Direct-acting Antiviral Combination (NS5A Inhibitor + NS5B Polymerase Inhibitor)
Dosage Form: Tablet
Strength: 90mg/400mg

Lesovir-C combines ledipasvir (NS5A replication complex inhibitor) and sofosbuvir (NS5B polymerase inhibitor nucleotide analog prodrug). The dual mechanism targets different stages of HCV replication, providing potent pangenotypic antiviral activity with high barrier to resistance.

Indications

• Chronic Hepatitis C virus (HCV) genotype 1, 4, 5, and 6 infection in adults
• Treatment-naive and treatment-experienced chronic HCV patients
• HCV patients with or without cirrhosis
• HCV/HIV co-infected patients

Dosage & Administration

Adults: 1 tablet (Ledipasvir 90mg/Sofosbuvir 400mg) once daily with or without food for 8, 12, or 24 weeks depending on genotype, prior treatment history, and degree of liver fibrosis. Specialist hepatologist prescription required.

Contraindications & Precautions

• Hypersensitivity to ledipasvir, sofosbuvir, or excipients
• Co-administration with rifampicin, rifabutin (reduce sofosbuvir levels)
• Severe renal impairment (GFR <30 mL/min) — co-administration with amiodarone contraindicated
• Pregnancy: use only if clearly needed

Side Effects

Common: fatigue, headache, nausea, diarrhea, insomnia. Bradycardia reported when co-administered with amiodarone.

Drug Interactions

Amiodarone: serious symptomatic bradycardia — contraindicated. Rifampicin, St. John's Wort: reduce ledipasvir/sofosbuvir levels. Antacids containing aluminium/magnesium: separate by 4 hours.

Storage

Store below 30°C, away from moisture and direct sunlight. Keep out of reach of children.

Medical Disclaimer: This information is for reference purposes only and is not a substitute for professional medical advice. Lesovir is a prescription/pharmacy medicine. Always consult a qualified physician or pharmacist before use. Self-medication can be harmful. Diabetesstore.com.bd strongly recommends obtaining a valid prescription for this medication.