LEVOCAR 100ml Oral Solution

Overview

Levocar 100 ml Oral Solution contains Levocarnitine, a naturally occurring substance essential for cellular energy metabolism, manufactured by Square Pharmaceuticals PLC. The oral liquid formulation provides a convenient alternative for patients who cannot take tablets, including children and those requiring precise dose titration. Levocarnitine facilitates long-chain fatty acid transport into the mitochondria for beta-oxidation and energy production, playing a vital role in skeletal and cardiac muscle metabolism.

Levocar oral solution is indicated for chronic fatigue syndrome, heart diseases including congestive heart failure, kidney disease, hyperlipidemia, intermittent claudication, dementia and memory impairment, Down syndrome, male infertility, and hyperthyroidism. For oral use only — not for parenteral administration.

Dosage and Administration

Adults: 10–30 ml/day. Start at 10 ml/day and increase slowly while assessing tolerance and therapeutic response. Higher doses should be administered with caution.

Infants and children: 50–100 mg/kg/day. Start at 50 mg/kg/day and increase slowly to a maximum of 30 ml/day. The solution can be given in 2–6 divided doses as directed by the physician.

Levocar oral solution may be taken alone or dissolved in a drink or other liquid food. Doses should be spaced evenly throughout the day, preferably during or following meals, and should be consumed slowly to maximise tolerance and minimise gastrointestinal side effects. For oral use only — do not administer parenterally.

Interaction

No major clinically significant drug interactions are documented for Levocarnitine at standard therapeutic doses. Patients receiving multiple medications should consult their physician before starting Levocar oral solution.

Contraindications

There are no absolute contraindications for Levocarnitine at therapeutic doses. Use with caution in patients with severe renal impairment or ESRD on dialysis, as metabolites (trimethylamine, trimethylamine-N-oxide) may accumulate due to reduced urinary excretion.

Side Effects

Levocar is generally well tolerated. Transient side effects may include nausea, vomiting, abdominal cramps, and diarrhea, usually associated with rapid consumption. These are minimised by taking the solution slowly with food.

Pregnancy and Lactation

There are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly necessary. Levocarnitine in nursing mothers has not been specifically studied; risks to the infant versus benefits to the mother should be assessed on an individual basis.

Precautions and Warnings

Always take slowly and with food to minimise gastrointestinal reactions. This formulation is strictly for oral use only and must not be administered parenterally. In patients with severe renal impairment or ESRD, chronic high-dose use may lead to accumulation of potentially toxic metabolites. Monitor closely in renally impaired patients.

Storage Conditions

Do not store above 30°C. Keep away from light. Keep out of reach of children.

Frequently Asked Questions

Q: Can Levocar oral solution be mixed with food or drinks?
A: Yes — Levocar oral solution can be taken alone or mixed with a drink or soft food. This can improve palatability and tolerance. Doses should be consumed slowly, preferably with meals, to reduce the risk of gastrointestinal upset.

Q: Is Levocar oral solution safe for children?
A: Yes, with appropriate weight-based dosing. The recommended paediatric dose is 50–100 mg/kg/day in divided doses, starting at 50 mg/kg/day and adjusting based on response, up to a maximum of 30 ml/day. Always follow the physician's specific dosage instructions.