Maxsulin 30/70 (100 IU) Vial

What is Maxsulin 30/70?

Maxsulin 30/70 is a premixed (biphasic) human insulin manufactured by Incepta Pharmaceuticals Ltd., combining 30% fast-acting regular insulin with 70% intermediate-acting NPH insulin in a single vial. It provides both mealtime and basal glucose coverage in one injection, reducing the number of daily injections needed compared to separate regular and NPH insulins.

Generic Name and Composition

Each mL contains 100 IU of Biphasic Insulin Human, consisting of 30% soluble (regular) insulin and 70% isophane (NPH) insulin, supplied in a 10 mL vial.

Indications

• Type 1 diabetes mellitus, as part of a structured insulin regimen
• Type 2 diabetes mellitus when oral antidiabetic agents are insufficient to control blood glucose
• Patients who prefer or require a simplified premixed insulin regimen over basal-bolus therapy

How It Works — Mechanism of Action

The regular insulin component acts quickly to control blood glucose rise after meals, while the NPH component provides a delayed, prolonged basal effect. Together, they lower blood glucose by promoting cellular glucose uptake and suppressing hepatic glucose production over an extended period.

Dosage and Administration

• Dosage is strictly individualized by a physician based on blood glucose monitoring, body weight, and meal patterns.
• Administered by subcutaneous injection, typically before breakfast and/or dinner.
• Gently roll/invert the vial before each use to re-suspend the cloudy insulin evenly — do not shake vigorously.
• Inject 15-30 minutes before a meal to align with the regular insulin component's onset.
• Rotate injection sites within the same body region to reduce lipodystrophy.

Side Effects

Common: Hypoglycemia, injection site reactions (redness, swelling, itching), lipodystrophy with repeated injections at the same site.

Uncommon: Weight gain, peripheral edema (especially when starting therapy).

Rare: Severe allergic reactions (generalized rash, angioedema, anaphylaxis), hypokalemia.

Drug Interactions

May increase hypoglycemia risk: Oral antidiabetic agents, ACE inhibitors, salicylates, alcohol.

May reduce insulin effect / raise blood glucose: Corticosteroids, thiazide diuretics, thyroid hormones, oral contraceptives.

Other considerations: Beta-blockers may mask symptoms of hypoglycemia; inform your doctor of all medicines you are taking.

Contraindications

• Known hypersensitivity to insulin human or any excipient
• Episodes of hypoglycemia requiring caution in dosing adjustment

Pregnancy and Lactation

Human insulin, including premixed formulations, is generally considered safe for use during pregnancy and breastfeeding under close physician supervision. Dose requirements often change during pregnancy and require close monitoring.

Precautions and Warnings

• Never share vials or syringes between patients due to infection transmission risk.
• Always verify the insulin type and concentration before each injection — do not interchange with other insulin brands or types without physician guidance.
• Closely monitor blood glucose, especially when changing dose, insulin brand, meal timing, or activity/diet patterns.
• Be aware of signs of hypoglycemia (sweating, palpitations, confusion) and carry a fast-acting sugar source.
• Store correctly — refrigerate unopened vials, keep in-use vials at room temperature, away from direct heat and sunlight.

Overdose

Overdose may cause severe hypoglycemia, with symptoms ranging from sweating and confusion to seizures and loss of consciousness. Mild cases can be managed with oral glucose; severe cases require immediate medical attention, including intravenous glucose or glucagon administration.

Storage Instructions

• Store unopened vials in a refrigerator (2-8°C); do not freeze.
• Once in use, the vial may be kept at room temperature (below 30°C) for up to 4 weeks, away from direct heat and light.
• Keep out of reach of children.
• Do not use after the expiry date printed on the pack.

Frequently Asked Questions

Q1: Why does Maxsulin 30/70 appear cloudy?
The NPH component is a suspension, giving the insulin a cloudy appearance. Gently roll or invert the vial to re-suspend it evenly before each injection — do not shake vigorously.

Q2: What does the "30/70" in the name mean?
It refers to the ratio of insulin types: 30% fast-acting regular insulin and 70% intermediate-acting NPH insulin, combined in one premixed formulation.

Q3: Can I adjust the ratio of regular to NPH insulin myself?
No — premixed insulins have a fixed ratio. If your blood glucose pattern requires a different ratio, your physician may switch you to Maxsulin 50/50 or to separate regular and NPH insulins.

Q4: How does Maxsulin 30/70 compare to Maxsulin 50/50?
Both are premixed insulins from Incepta; Maxsulin 30/70 contains 30% regular and 70% NPH insulin, while Maxsulin 50/50 contains an equal 50% split, which may better suit certain meal and glucose patterns as determined by your physician.

Medical Disclaimer

This product is available by prescription only (Rx) and should be used under medical supervision. The information provided is for educational purposes and does not replace professional medical advice. Always consult a registered physician before starting, stopping, or changing any insulin therapy. DiabetesStore.com.bd is a licensed online pharmacy in Bangladesh.