- Stock: In Stock
- Brand: Beximco Pharmaceutical
- Product ID: Metformin Hydrochloride
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Informet XR 500 mg Tablet — Metformin Hydrochloride (Extended Release)
| Generic Name | Metformin Hydrochloride (Extended Release) |
|---|---|
| Strength | 500 mg |
| Dosage Form | Extended-Release Tablet |
| Manufacturer | Beximco Pharmaceuticals Ltd. |
| Therapeutic Class | Biguanide — Oral Antidiabetic (Extended Release) |
| Pack Size | Standard Strip/Box |
Overview
Informet XR 500 mg is Beximco Pharmaceuticals Ltd.'s extended-release metformin tablet, offering once-daily dosing convenience and improved gastrointestinal tolerability for patients who experience discomfort with immediate-release metformin.
Mechanism of Action
The extended-release matrix releases metformin gradually over several hours, providing smoother plasma concentrations and reducing absorption-related gastrointestinal side effects, while retaining the same glucose-lowering mechanisms as standard metformin.
Indications
Informet XR 500 mg is indicated for type 2 diabetes mellitus, particularly for patients with gastrointestinal sensitivity to immediate-release metformin or those who prefer once-daily dosing for improved adherence.
Dosage and Administration
The typical starting dose is 500 mg once daily with the evening meal, increased in 500 mg increments at intervals of at least one week as needed, up to a maximum of 2000 mg once daily. Tablets must be swallowed whole and never crushed, split, or chewed.
Contraindications
Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²), metabolic acidosis including diabetic ketoacidosis, and known hypersensitivity to metformin.
Side Effects
Informet XR generally causes fewer gastrointestinal side effects than immediate-release metformin, though nausea or diarrhea can still occur during dose titration. Long-term use may reduce vitamin B12 absorption. An inert tablet remnant occasionally seen in stool is a normal feature of extended-release formulations.
Drug Interactions
Iodinated contrast media require temporary discontinuation of metformin. Alcohol intake should be limited. Disclose all current medications and supplements to your physician or pharmacist.
Special Precautions
Do not switch between immediate-release and extended-release metformin without physician guidance. Renal function should be assessed before initiation and monitored periodically.
Storage
Store below 30°C in a dry place, protected from light. Keep out of reach of children.
Frequently Asked Questions
Q1: How does Informet XR differ from regular Informet tablets?
Informet XR releases metformin gradually over several hours, allowing once-daily dosing with generally better gastrointestinal tolerability.
Q2: What time of day should I take Informet XR 500?
It is generally recommended with the evening meal, but follow your physician's specific instructions for your regimen.
Q3: Is seeing a tablet remnant in stool with Informet XR concerning?
No, this is a normal and harmless feature of extended-release tablet shells passing through the digestive tract.
Q4: Can Informet XR 500 be combined with other diabetes medications?
Yes, it is often combined with other oral antidiabetic agents or insulin as directed by your physician.
Medical Disclaimer: This information is provided for educational purposes only and does not replace professional medical advice. Always consult a registered physician or pharmacist before starting, stopping, or changing any medication. Dosage and suitability vary by individual health condition.
